A5086114384- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Renal Transplantation Outcomes and Treatments
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Congenital Heart Disease Studies
- Cardiovascular and exercise physiology
- Organ Transplantation Techniques and Outcomes
- Fuel Cells and Related Materials
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Botanical Studies and Applications
- Cardiac Arrhythmias and Treatments
- Cardiac Health and Mental Health
- Frailty in Older Adults
- Long-Term Effects of COVID-19
- Hemodynamic Monitoring and Therapy
- Tissue Engineering and Regenerative Medicine
- Geriatric Care and Nursing Homes
- Medication Adherence and Compliance
University of Michigan
2016-2025
Michigan Medicine
2015-2024
Michigan United
2023-2024
Hanoi Open University
2024
Ann Arbor VA Medical Center
2006-2023
Leiden University Medical Center
2023
Medizinische Hochschule Hannover
2023
University Hospital of Wales
2023
Mallinckrodt (United States)
2023
Deaconess Hospital
2023
The use of left ventricular assist devices is an accepted therapy for patients with refractory heart failure, but current pulsatile volume-displacement have limitations (including large pump size and limited long-term mechanical durability) that reduced widespread adoption this technology. Continuous-flow pumps are newer types developed to overcome some these limitations.In a prospective, multicenter study without concurrent control group, 133 end-stage failure who were on waiting list...
Background Risk stratification of patients with end-stage congestive heart failure is a critical component the transplant candidate selection process. Accurate identification individuals most likely to survive without would facilitate more efficient use scarce donor organs. Methods and Results Multivariable proportional hazards survival models were developed data on 80 clinical characteristics from 268 ambulatory advanced (derivation sample). Invasive noninvasive (with...
In two interim analyses of this trial, patients with advanced heart failure who were treated a fully magnetically levitated centrifugal-flow left ventricular assist device less likely to have pump thrombosis or nondisabling stroke than mechanical-bearing axial-flow device.We randomly assigned receive either the irrespective intended goal use (bridge transplantation destination therapy). The composite primary end point was survival at 2 years free disabling reoperation replace remove...
Mechanical circulatory support with a left ventricular assist device (LVAD) is an established treatment for patients advanced heart failure. We compared newer LVAD design (a small intrapericardial centrifugal-flow device) against existing technology commercially available axial-flow in failure who were ineligible transplantation.
Continuous-flow left ventricular assist systems increase the rate of survival among patients with advanced heart failure but are associated development pump thrombosis. We investigated effects a new magnetically levitated centrifugal continuous-flow that was engineered to avert
Contemporary ventricular assist device therapy results in a high rate of successful heart transplantation but is associated with bleeding, infections, and other complications. Further reductions pump size, centrifugal design, intrapericardial positioning may reduce complications improve outcomes.We studied small, intrapericardially positioned, continuous-flow patients requiring an implanted as bridge to transplantation. The course investigational recipients was compared that...
Although interventions combining patient education and postdischarge management have demonstrated benefits in patients with chronic heart failure, the benefit attributable to alone is not known. We hypothesized that a discharge program would improve clinical outcomes failure.We conducted randomized, controlled trial of 223 systolic failure compared effects 1-hour, one-on-one teaching session nurse educator standard process. Subjects were contacted by telephone at 30, 90, 180 days collect...
Background— Myocardial recovery after left ventricular assist device (LVAD) support has been reported. The LVAD Working Group Recovery Study was a prospective multicenter trial to assess the incidence of myocardial in patients bridged cardiac transplantation. Methods and Results— After implantation, were evaluated with use rest echocardiograms partial cardiopulmonary exercise testing. Dobutamine echocardiography hemodynamic measurements performed those ejection fraction >40% during...
Aortic insufficiency (AI) following left ventricular assist device (LVAD) placement can affect performance. The aim of this study was to examine AI development LVAD implantation.Echocardiograms (n=315) from 78 subjects undergoing HeartMate-XVE (n=25 [32%]) or HeartMate-II (n=53 [68%]) implantations 2004 2008 were reviewed. Studies obtained preoperatively and at 1, 3, 6, 12, 18, 24 months after surgery. graded on an interval scale (0=none, 0.5=trivial, 1=mild, 1.5=mild-moderate, 2=moderate,...
The aim of this study was to prospectively evaluate the impact blood pressure management on stroke rates in patients receiving HeartWare HVAD System. ENDURANCE trial demonstrated noninferiority System versus control (HeartMate II) with advanced heart failure ineligible for transplantation. However, more common subjects. Post hoc analyses increased mean arterial as a significant independent risk factor stroke. Supplemental Trial prospective, multicenter evaluation 465 transplantation,...
PURPOSE: In contrast to renal and hepatic failure, congestive heart failure (CHF) has not been associated with a defined metabolic bone disorder. However, low mass reported in patients CHF who receive cardiac transplant. Both the pathophysiology therapy of may influence mineral homeostasis evidence that calciotropic hormones affect cardiovascular function is accumulating. Therefore, we evaluated severe determine prevalence osteoporosis characterize relationships between homeostasis,...
The use of extracorporeal life support (extracorporeal membrane oxygenation [ECMO]) as a direct bridge to heart transplant in adult patients is associated with poor survival. Similarly, the an implantable left ventricular assist device (LVAD) salvage cardiac arrest, severe hemodynamic instability, and multiorgan failure results outcome. LVAD implant who present cardiogenic shock have not been evaluated for transplantation or sustained recent myocardial infarction also raises concerns. ECMO...