A5102966010- Neurobiology and Insect Physiology Research
- Ion channel regulation and function
- Developmental Biology and Gene Regulation
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Genetics, Aging, and Longevity in Model Organisms
- Plant Molecular Biology Research
- Cellular transport and secretion
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Axon Guidance and Neuronal Signaling
- Receptor Mechanisms and Signaling
- Invertebrate Immune Response Mechanisms
- Animal Behavior and Reproduction
- RNA Research and Splicing
- Cellular Mechanics and Interactions
- Insect and Arachnid Ecology and Behavior
- Erythrocyte Function and Pathophysiology
- Retinal Development and Disorders
- Wnt/β-catenin signaling in development and cancer
- Animal Genetics and Reproduction
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
Howard Hughes Medical Institute
2016-2025
University of California, San Francisco
2016-2025
VIB-KU Leuven Center for Brain & Disease Research
2022
Czech Academy of Sciences, Institute of Physiology
2012-2014
Ludwig-Maximilians-Universität München
2013
Emory University
2013
Cook Children's Medical Center
2013
First Pavlov State Medical University of St. Petersburg
2013
Institute of Molecular Biology and Biophysics
2007-2013
Duke University
2013
The small GTPases of the Rac/Rho/Cdc42 subfamily are implicated in actin cytoskeleton-membrane interaction mammalian cells and budding yeast. vivo functions these multicellular organisms not known. We have cloned Drosophila homologs rac CDC42, Drac1, Dcdc42. They share 70% amino acid sequence identity with each other, both highly expressed nervous system mesoderm during neuronal muscle differentiation, respectively. putative constitutively active dominant-negative Drac1 proteins tissues....
Antibodies specific for horseradish peroxidase (HRPeroxase) bind to neuronal membranes in Drosophila and serve as a marker. Immunocytochemical staining with these antibodies marks sensory neurons, peripheral nerves, fiber tracks the central nervous system of embryos, larvae, adult flies. Similar patterns also were seen embryos grasshopper. It appears that an antigen associated appearing early differentiation is recognized by HRPeroxase. Using this method, we followed embryogenesis found...
On the basis of electrophysiological analysis Shaker mutants, locus Drosophila melanogaster has been proposed to encode a structural component voltage-dependent potassium channel, A channel. Unlike sodium channels, acetylcholine receptors, and calcium K+ channels have not purified biochemically. To facilitate biochemical studies genomic DNA from cloned. Rearrangements in five mutants mapped 60-kilobase segment genome. Four complementary clones analyzed. These indicate that gene contains...
Potassium currents are crucial for the repolarization of electrically excitable membranes, a role that makes potassium channels target physiological modifications alter synaptic efficacy. The Shaker locus Drosophila is thought to encode K + channel. sequence two complementary DNA clones from reported here. predicts an integral membrane protein 70,200 daltons containing seven potential membrane-spanning sequences. In addition, predicted homologous vertebrate sodium channel in region...
Normal Drosophilia learn to avoid an odorant associated with electric shock. An X-linked mutant, dunce, has been isolated that fails display this learning in spite of being able sense the and shock showing essentially normal behavior other respects.
Insect dendritic arborization (da) neurons provide an opportunity to examine how diverse dendrite morphologies and territories are established during development. We have examined the of Drosophila da by using MARCM (mosaic analysis with a repressible cell marker) system. show that each 15 per abdominal hemisegment spread dendrites characteristic regions epidermis. place these into four distinct morphological classes distinguished primarily their branching complexities. Some class...
The anatomy and physiology of the Drosophila larval neuromuscular junction were studied. 2. dependence muscle resting potentials on [K+]o [Na+]o follows Goldman-Hodgkin-Katz equation (PNa/PK=0-23). Chloride ions distribute passively across membrane. 3. mean specific membrane resistance fibres is 4-3 X 10(3) omega cm2, capacitance 7-1 muF/cm2. fibre virtually isopotential. 4. Transmitter release quantal. Both miniature excitatory junctional potential evoked follow Poisson distribution. 5....
For more than 100 years, the fruit fly