A5067523922- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Engineering and Material Science Research
- Olfactory and Sensory Function Studies
- Zebrafish Biomedical Research Applications
- Smart Materials for Construction
- Insect behavior and control techniques
- Axon Guidance and Neuronal Signaling
- CRISPR and Genetic Engineering
- Biochemical Analysis and Sensing Techniques
- Insect symbiosis and bacterial influences
- Neurogenesis and neuroplasticity mechanisms
- Physiological and biochemical adaptations
- Insect Utilization and Effects
University of California, Berkeley
2021-2022
Salk Institute for Biological Studies
2011-2018
University of California, San Diego
2011-2015
Laboratory of Molecular Genetics
2014
La Jolla Alcohol Research
2014
University of Pennsylvania
2010
For more than 100 years, the fruit fly
Chemosensory neurons extract information about chemical cues from the environment. How is activity in these sensory transformed into behavior? Using Caenorhabditis elegans, we map a novel neuron circuit motif that encodes odor concentration. Primary neurons, AWCON and AWA, directly detect food benzaldehyde (BZ) release insulin-like peptides acetylcholine, respectively, which are required for odor-evoked responses secondary ASEL AWB. Consistently, both primary BZ attraction. Unexpectedly,...
Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using interactions between Caenorhabditis elegans its predator, Pristionchus pacificus, we show that neuronal perception C. of a predator-specific molecular signature induces instantaneous escape prolonged reduction in oviposition. Chemical analysis revealed this consist class sulfolipids, produced biochemical pathway required for developing...
Mature behaviors emerge from neural circuits sculpted by genetic programs and spontaneous evoked activity. However, how activity is refined to drive maturation of learned behavior remains poorly understood. Here, we explore transient hormonal signaling coordinates a state transition associative learning. We identify spontaneous, asynchronous in Drosophila learning memory brain region, the mushroom body. This declines significantly over first week adulthood. Moreover, this generated...
The chemokine SDF1 activates a cAMP-mediated signaling pathway that antagonizes retinal responses to the midline repellent slit. We show knocking down calmodulin-activated adenylate cyclase ADCY8 makes axons insensitive SDF1. Experiments in vivo using male and female zebrafish ( Danio rerio ) confirm mutual antagonism between slit ADCY8-mediated signaling. Unexpectedly, knockdown of or another cyclase, ADCY1, induces ipsilateral misprojections would normally cross ventral midline....
Neuropeptide signaling remodels the composition of a chemosensory circuit and shapes behavior in Caenorhabditis elegans. We reported that ASE left (ASEL) salt sensory neuron uses proprotein convertase, BLI-4, to cleave insulin-like peptide INS-6. INS-6 peptides are released from ASEL response large, but not small changes stimuli. Fast functionally transforms AWC olfactory into an interneuron neural for high salt. This new configuration potentiates behavioral attraction Here, context genes,...
Abstract Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using interactions between Caenorhabditis elegans its predator, Pristionchus pacificus , we show that neuronal perception C. of a predator-specific molecular signature induces instantaneous escape prolonged reduction in oviposition. Chemical analysis revealed this consist class sulfolipids, produced biochemical pathway required for...