A5035420987- Machine Learning in Bioinformatics
- Gut microbiota and health
- Glycosylation and Glycoproteins Research
- Protein Structure and Dynamics
- Genomics and Phylogenetic Studies
- Probiotics and Fermented Foods
- Microbial Community Ecology and Physiology
- Metabolomics and Mass Spectrometry Studies
- Clostridium difficile and Clostridium perfringens research
- Insect behavior and control techniques
- Bacteriophages and microbial interactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Insect symbiosis and bacterial influences
- Dermatology and Skin Diseases
- Autism Spectrum Disorder Research
- Environmental DNA in Biodiversity Studies
- Insect Utilization and Effects
- Diet and metabolism studies
- Methane Hydrates and Related Phenomena
- CRISPR and Genetic Engineering
- Insect Pest Control Strategies
- Coconut Research and Applications
- Bioinformatics and Genomic Networks
- Pesticide Residue Analysis and Safety
- Ginseng Biological Effects and Applications
Indian Institute of Science Education and Research, Bhopal
2014-2024
Champalimaud Foundation
2020-2022
For more than 100 years, the fruit fly
Metagenomic studies carried out in the past decade have led to an enhanced understanding of gut microbiome human health; however, Indian has not been well explored. We analyzed 110 healthy individuals from two distinct locations (North-Central and Southern) India using multi-omics approaches, including 16S rRNA gene amplicon sequencing, whole-genome shotgun metagenomic metabolomic profiling fecal serum samples.The catalogue established this study emphasizes uniqueness comparison other...
Recently, dysbiosis in the human gut microbiome and shifts relative abundances of several bacterial species have been recognized as important factors colorectal cancer (CRC). However, these studies carried out mainly developed countries where CRC has a high incidence, it is unclear whether host-microbiome relationships deduced from can be generalized to global population. To test if documented associations between are conserved distinct context, we performed metagenomic metabolomic...
Tuberculosis (TB) is primarily associated with decline in immune health status. As gut microbiome (GM) implicated the regulation of host immunity and metabolism, here we investigate GM alteration TB patients by 16S rRNA gene whole-genome shotgun sequencing. The study group constituted pulmonary their healthy household contacts as controls (HCs). Significant microbial taxonomic functional capacity was observed active compared to HCs. We that Prevotella Bifidobacterium abundance were HCs,...
The identification of virulent proteins in any de-novo sequenced genome is useful estimating its pathogenic ability and understanding the mechanism pathogenesis. Similarly, such could be valuable comparing metagenome healthy diseased individuals proportion species. However, common challenge both above tasks since a significant genomic metagenomic are novel yet unannotated. currently available tools which carry out provide limited accuracy cannot used on large datasets. Therefore, we have...
Extreme ecosystems such as hot springs are of great interest a source novel extremophilic species, enzymes, metabolic functions for survival and biotechnological products. India harbors hundreds springs, the majority which not yet explored require comprehensive studies to unravel their unknown untapped phylogenetic functional diversity. The aim this study was perform large-scale metagenomic analysis three major located in central namely, Badi Anhoni, Chhoti Anhoni Tattapani at two...
Abstract The impact of commensal bacteria on the host arises from complex microbial-diet-host interactions. Mapping metabolic interactions in gut microbial communities is therefore key to understand how microbiome influences host. Here we use an interdisciplinary approach including isotope-resolved metabolomics show that Drosophila melanogaster, Acetobacter pomorum ( Ap ) and Lactobacillus plantarum Lp a syntrophic relationship established overcome detrimental diets identify as bacterium...
Several scalp microbiome studies from different populations have revealed the association of dandruff with bacterial and fungal dysbiosis. However, functional role microbiota in disorder health remains scarcely explored. Here, we examined diversity their potential healthy 140 Indian women. Propionibacterium acnes Staphylococcus epidermidis emerged as core species, where former was associated a latter scalp. Along commonly occurring Malassezia species (M. restricta M. globosa) on scalp,...
Abstract The abundance and diversity of host-associated Prevotella species have a profound impact on human health. To investigate the composition, diversity, functional roles in gut, population-wide analysis was carried out 586 healthy samples from western non-western populations including largest Indian cohort comprising 200 samples, 189 Inflammatory Bowel Disease populations. A higher copri enriched complex plant polysaccharides metabolizing enzymes, particularly pullulanase containing...
Abstract Background Yamuna, a major tributary of Ganga, which flows through the national capital region Delhi, is among polluted rivers in India. The accumulation various effluents, toxic chemicals, heavy metals, and increased organic load Yamuna directly affects organisms that thrive inside or around this river. It also makes it an ideal site for studying impact pollution on river microflora, are sentinels water quality. Results In study, microbial community structure functional diversity...
The efficacy of antibiotics against bacterial infections is decreasing due to the development resistance in bacteria, and thus, there a need search for potential alternatives antibiotics. In this scenario, peptidoglycan hydrolases can be used as alternate antibacterial agents their unique property cleaving cell wall present both gram-positive gram-negative bacteria. Along with role maintaining overall turnover daughter separation, also play crucial pathophysiology requiring computational...
Abstract Dandruff is a recurrent chronic scalp disorder, affecting majority of the population worldwide. Recently metagenomic study Indian microbiome described an imperative role bacterial commensals in providing essential vitamins and amino acids to scalp. Coconut oil its formulations are commonly applied on several parts world maintain health. Thus, this we examined effect topical application coconut (bacterial fungal) at taxonomic functional levels their correlation with physiological...
Abstract Ocean microbiome is crucial for global biogeochemical cycles and primary productivity. Despite numerous studies investigating the ocean microbiomes, composition of Andaman region Indian remains largely unexplored. While this harbors pristine biological diversity, escalating anthropogenic activities along coastal habitats exert an influence on microbial ecology impact aquatic ecosystems. We investigated in waters Islands by 16S rRNA gene amplicon metagenomic shotgun sequencing...
The indiscriminate use of pesticides in agricultural commodities has become a global health concern. Various household methods are employed to remove pesticide residues from commodities, e.g., water and ozone. Many ozone-based commercial removal machines available the market for general public. current study compares efficiency washing fruits vegetables simple tap through commercially its risk assessment different age groups consumers. okra green chili were treated with acetamiprid ethion as...
Tepidimonas taiwanensis strain MB2 is a thermophile isolated from hot spring located in central India. Here, we report 28,49,160 bp draft genome sequence of MB2. The shows properties sulfur metabolism, nitrogen fixation, ammonia assimilation organic acids, and wide variety proteases.
This paper reports the draft genome sequence of proteobacterium Gulbenkiania mobilis strain MB1, a sulfur-metabolizing thermophile isolated from hot spring located in Pachmarhi, India. study first any species genus Gulbenkiania.