A5006294658- Invertebrate Immune Response Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Chromatin Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Marine and coastal plant biology
- Chromosomal and Genetic Variations
- Gene Regulatory Network Analysis
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Silkworms and Sericulture Research
- Insect behavior and control techniques
- Marine Ecology and Invasive Species
- Attachment and Relationship Dynamics
- Single-cell and spatial transcriptomics
- Insect symbiosis and bacterial influences
- CRISPR and Genetic Engineering
- Marine Biology and Environmental Chemistry
VIB-KU Leuven Center for Brain & Disease Research
2022-2024
KU Leuven
2022-2023
VIB-KU Leuven Center for Cancer Biology
2022
Université Paris Sciences et Lettres
2020
Centre National de la Recherche Scientifique
2020
Institut de Biologie de l'École Normale Supérieure
2020
Inserm
2020
École Normale Supérieure - PSL
2020
For more than 100 years, the fruit fly
Abstract With the growing number of single-cell analysis tools, benchmarks are increasingly important to guide and method development. However, a lack standardisation extensibility in current limits their usability, longevity, relevance community. We present Open Problems, living, extensible, community-guided benchmarking platform including 10 tasks that we envision will raise standards for selection, evaluation, development methods analysis.
Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress balance the activation of multiple programs, including apoptosis, proliferation, cell migration. Central those responses JNK/MAPK JAK/STAT signaling pathways. Yet, what extent these cascades interact at cis-regulatory level how they orchestrate different regulatory phenotypic is still unclear. Here, we aim characterize states that emerge...
Precise patterns of gene expression are driven by interactions between transcription factors, regulatory DNA sequences, and chromatin. How mutations affecting any one these "layers" buffered or propagated to remains unclear. To address this, we quantified allele-specific changes in chromatin accessibility, histone modifications, F1 embryos generated from eight Drosophila crosses at three embryonic stages, yielding a comprehensive data set 240 samples spanning multiple layers. Genetic...
During sea urchin development, secretion of Nodal and BMP2/4 ligands their antagonists Lefty Chordin from a ventral organizer region specifies the dorsal territories. This process relies on complex interplay between BMP pathways through numerous regulatory circuits. To decipher these pathways, we used combination treatments with recombinant proteins computational modelling approach. We assembled logical model focusing cell responses to signalling inputs along dorsal-ventral axis, which was...
Abstract Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress balance the activation of multiple including apoptosis, proliferation, cell migration. Central those responses JNK/MAPK JAK/STAT signaling pathways. Yet, what extent these cascades interact at cis -regulatory level, how they orchestrate different regulatory phenotypic is still unclear. Here, we aim characterize states that emerge...
Abstract Precise patterns of gene expression are driven by interactions between transcription factors, regulatory DNA sequence, and chromatin. How mutations affecting any one these ‘layers’ is buffered or propagated to remains unclear. To address this, we quantified allele-specific changes in chromatin accessibility, histone modifications, F1 embryos generated from eight Drosophila crosses, at three embryonic stages, yielding a comprehensive dataset 240 samples spanning multiple layers....
Abstract During sea urchin development, secretion of Nodal and BMP2/4 ligands their antagonists Lefty Chordin from a ventral organizer region specifies the dorsal territories. This process relies on complex interplay between BMP pathways through numerous regulatory circuits. To decipher these pathways, we used combination treatments with recombinant proteins computational modelling approach. We assembled logical model focusing cell responses to signalling inputs along dorsal-ventral axis,...