A5064135853- Neurobiology and Insect Physiology Research
- Erythrocyte Function and Pathophysiology
- Ion Channels and Receptors
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Insect symbiosis and bacterial influences
- CRISPR and Genetic Engineering
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
- Plant and animal studies
- Photoreceptor and optogenetics research
- Insect Utilization and Effects
- Cellular transport and secretion
- Hippo pathway signaling and YAP/TAZ
- Lipid metabolism and biosynthesis
- Cellular Mechanics and Interactions
- Cloud Computing and Resource Management
- Lysosomal Storage Disorders Research
- IoT and Edge/Fog Computing
- Neural dynamics and brain function
- Software System Performance and Reliability
- Insect behavior and control techniques
- Insect Pest Control Strategies
- Force Microscopy Techniques and Applications
University of California, San Francisco
2016-2024
Howard Hughes Medical Institute
2017-2022
Chinese Academy of Sciences
2011-2018
Shanghai Institutes for Biological Sciences
2011-2016
University of Chinese Academy of Sciences
2011-2016
Center for Excellence in Brain Science and Intelligence Technology
2016
For more than 100 years, the fruit fly
Abstract Cells sense physical forces and convert them into electrical or chemical signals, a process known as mechanotransduction. Whereas extensive studies focus on mechanotransduction at the plasma membrane, little is about whether how intracellular organelles mechanical force physiological functions of organellar mechanosensing. Here we identify Drosophila TMEM63 ( Dm TMEM63) ion channel an intrinsic mechanosensor lysosome, major degradative organelle. Endogenous proteins localize to...
Significance Locomotion requires peripheral sensory feedback from mechanosensitive proprioceptors. The molecular mechanisms underlying this proprioceptive locomotion control are largely unknown. Here we report that tmc , the Drosophila ortholog of mammalian deafness gene tmc1 is expressed in larval neurons and these require transmembrane channel-like (TMC) to respond bending body. We further loss TMC function causes defects. Finally, TMC1/2 shown rescue defects mutant larvae, providing...
Disruptions in lipid homeostasis have been observed many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the molecular mechanisms of how affects unclear. We find easily shocked (eas), which encodes a kinase critical role phospholipid phosphatidylethanolamine (PE) synthesis, and two other enzymes this synthesis pathway required cell autonomously sensory neurons for growth stability. Furthermore, we show level Sterol Regulatory Element-Binding...
Light activation and inactivation of neurons by optogenetic techniques has emerged as an important tool for studying neural circuit function. To achieve a high resolution, new methods are being developed to selectively manipulate the activity individual neurons. Here, we report that combination acousto-optic device (AOD) single-photon laser was used rapid precise spatiotemporal control light stimulation at multiple points in with millisecond time resolution. The performance this system...
The Drosophila melanogaster TRPA family member painless, expressed in a subset of multidendritic neurons embeding the larval epidermis, is necessary for nociception noxious heat or mechanical stimuli. However, function painless adult flies remains largely unknown. Here we report that mutation leads to defect male–male courtship behavior and alteration olfaction sensitivity flies. Specific downregulation expression Painless protein olfactory projection (PNs) antennal lobes (ALs) resulted...