Yashoda Sharma
A5047644183- Inflammatory Bowel Disease
- Mobile Health and mHealth Applications
- Helicobacter pylori-related gastroenterology studies
- Digital Mental Health Interventions
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Genetic factors in colorectal cancer
- Microscopic Colitis
- Eosinophilic Esophagitis
- Genetic Associations and Epidemiology
- Hematopoietic Stem Cell Transplantation
- Plant Molecular Biology Research
- Neurobiology and Insect Physiology Research
- Health Literacy and Information Accessibility
- RNA Research and Splicing
- Liver Diseases and Immunity
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Gastric Cancer Management and Outcomes
- Celiac Disease Research and Management
- Developmental Biology and Gene Regulation
- Immune Cell Function and Interaction
- Gut microbiota and health
- Social Media in Health Education
- Colorectal Cancer Surgical Treatments
University of Iowa
2002-2023
Community Health Center
2021-2022
Yale University
2010-2019
Icahn School of Medicine at Mount Sinai
2016-2019
University Hospital of Zurich
2011
Carnegie Mellon University
2011
Jackson Laboratory
2005-2010
Full realization of the value loxP-flanked alleles generated by International Knockout Mouse Consortium will require a large set well-characterized cre-driver lines. However, many cre driver lines display excision activity beyond intended tissue or cell type, and these data are frequently unavailable to potential user. Here we describe high-throughput pipeline extend characterization document in wide range tissues at multiple time points disseminate scientific community. Our results show...
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Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two inflammatory bowel diseases (IBD). These discoveries already had a tremendous impact on our understanding of the genetic architecture directed functional revealed some biological functions are important to IBD (e.g. autophagy). Nonetheless, can only explain small proportion variance...
Background Preterm birth is an enormous public health problem, affecting over 12% of live births and costing $26 billion in the United States alone. The causes are complex, but twin studies support role genetics determining gestation length. Despite widespread use mouse preterm birth, there have been few that actually address precise natural length mouse, to what degree timing labor genetically determined. Methodology/Principal Findings To further develop as a genetic model we developed...
Abstract Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the architecture of trait remains largely unknown. The recent development machine learning (ML) approaches incited us to apply them classify healthy and diseased people according their genomic information. Immunochip dataset containing 18,227 CD patients 34,050 controls enrolled genotyped by international Inflammatory Bowel...
Significance Locomotion requires peripheral sensory feedback from mechanosensitive proprioceptors. The molecular mechanisms underlying this proprioceptive locomotion control are largely unknown. Here we report that tmc , the Drosophila ortholog of mammalian deafness gene tmc1 is expressed in larval neurons and these require transmembrane channel-like (TMC) to respond bending body. We further loss TMC function causes defects. Finally, TMC1/2 shown rescue defects mutant larvae, providing...
Abstract As the use of connected devices rises, an understanding how digital health technologies can be used for equitable healthcare across diverse communities is needed. We surveyed 1007 adult patients at six Federally Qualified Health Centers regarding wearable fitness trackers. Findings indicate majority interest in having Barriers included cost and lack information, revealing that broad device adoption requires education, investment, high-touch methods.
Neutralizing autoantibodies (Abs) against granulocyte-macrophage colony-stimulating factor (GM-CSF Ab) have been associated with stricturing ileal Crohn's disease (CD) in a largely pediatric patient cohort (total 394, adult CD 57). The aim of this study was to examine association 2 independent predominantly inflammatory bowel cohorts.Serum samples from 742 subjects the NIDDK IBD Genetics Consortium and 736 Australia were analyzed for GM-CSF Ab genetic markers. We conducted multiple...
Abstract Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating conferring protection inflammatory bowel exploiting knowledge common associated with the same disease. Through replication genotyping and imputation found that predicted variant (rs36095412, p.R179X, genotyped 11,148 ulcerative colitis patients 295,446 controls, MAF=up 0.78%) RNF186 , single-exon...
ABSTRACT Genome-wide association studies have identified over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key roles for genes involved in bacterial response and innate defense. More high-throughput vivo systems are required to rapidly evaluate therapeutic agents. We visualize, zebrafish, the effects on epithelial barrier function intestinal autophagy of one-course repetitive injury. Repetitive injury induces increased mortality, impaired...
The pandemic provided a stark reminder of the inequities faced by populations historically marginalized health care system and accelerated adoption digital technologies to drive innovation. Digital technologies’ purported promises reduce inefficiencies costs, improve access outcomes, empower patients add new level urgency equity. As conventional medicine shifts toward medicine, we have opportunity intentionally develop deploy with an inclusion focus. first step is ensuring that multiple...
<b><i>Introduction:</i></b> Increased genomics knowledge and access are advancing precision medicine care delivery. With the translation of across health care, genetics will play a greater role in primary services. Health disparities inadequate representation racial ethnically diverse groups threaten equitable for those historically underserved. provider awareness, knowledge, perceived importance important determinants utilization genomic applications....