A5016721210- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Diversity and Career in Medicine
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Healthcare Policy and Management
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Immune Response and Inflammation
- Behavioral Health and Interventions
- Obesity and Health Practices
- Dietary Effects on Health
- Diverticular Disease and Complications
- Pancreatitis Pathology and Treatment
- Optimism, Hope, and Well-being
- Whipple's Disease and Interleukins
- Primary Care and Health Outcomes
- Immune cells in cancer
Quinnipiac University
2021
Icahn School of Medicine at Mount Sinai
2018-2019
Crohn’s disease (CD)–associated variants in the LRRK2 gene for risk (N2081D) and protection (N551K) mediate shared effects CD Parkinson’s disease.
To identify factors that regulate gut microbiota density and the impact of varied on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, therapeutic interventions. Physiologic features host (carrying capacity) fitness shape density. Therapeutic manipulation mice altered metabolic immune homeostasis. In humans, was reduced Crohn’s ulcerative colitis, ileal pouch-anal anastomosis. The recurrent Clostridium difficile infection had lower were...
Recurrent and severe Clostridium difficile infections (CDI) are treated with fecal microbiota transplant (FMT). Uncertainty exists regarding FMT effectiveness for CDI underlying inflammatory bowel disease (IBD) its effects on activity in transferring the donor to patients without IBD. Subjects IBD who underwent recurrent or between 2013 2016 at The Mount Sinai Hospital were followed up 6 months. primary outcome was recurrence months after FMT. Secondary outcomes (1) 2 FMT; (2) frequency of...
ABSTRACT Genome-wide association studies have identified over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key roles for genes involved in bacterial response and innate defense. More high-throughput vivo systems are required to rapidly evaluate therapeutic agents. We visualize, zebrafish, the effects on epithelial barrier function intestinal autophagy of one-course repetitive injury. Repetitive injury induces increased mortality, impaired...
Summary To identify factors that regulate gut microbiota density and the impact of varied on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, therapeutic interventions. Physiologic features host (carrying capacity) fitness shape density. Therapeutic manipulation mice altered metabolic immune homeostasis. In humans, was reduced Crohn’s ulcerative colitis, ileal pouch-anal anastomosis. The recurrent Clostridium difficile infection had lower...
Abstract Background & Aims Recurrent and refractory Clostridium difficile infections (CDI) are effectively treated with fecal microbiota transplant (FMT). Uncertainty exists regarding the effectiveness of FMT for CDI underlying inflammatory bowel disease (IBD), its effects on activity transferring donor microbiome to patients without IBD. This study aims determine FMTs in subjects IBD, impact IBD activity, level engraftment, predictors recurrence. Methods Subjects who underwent recurrent...
Abstract Education interventions that increase osteoporosis knowledge and address health beliefs self-efficacy help older adults make informed decisions to prevent manage the disease. The aim of this study was determine if clinical risk factors for moderate effect a multifaceted education intervention on knowledge, beliefs, self-efficacy. Patients 50 years with no prior diagnosis or treatment were referred by their primary care provider bone mineral density testing DXA randomized an group (n...
Abstract: Acquired jejunal diverticulosis is a rare disorder with an unclear pathophysiology that potentially related to abnormalities in the smooth muscle layer, myenteric plexus or peristaltic defects and increased intraluminal pressures leading herniation. Typically occurring patients older than 60 years of age, can present without any symptoms, as chronic, nonspecific gastrointestinal complaints, have acute onset high mortality rates for complications such ileus, fistula, hemorrhage most...