A5085824896- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Genomics and Chromatin Dynamics
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Developmental Biology and Gene Regulation
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- NF-κB Signaling Pathways
University of California, San Diego
2015-2024
Weizmann Institute of Science
2022
La Jolla Institute For Molecular Medicine
2012
Moores Cancer Center
2006-2008
Tufts Medical Center
2007
Molecular Oncology (United States)
2007
Torrey Pines Institute For Molecular Studies
2005
St. Jude Children's Research Hospital
1999
Scripps Research Institute
1999
University of California, Berkeley
1999
The E2A gene products, E12 and E47, are critical for proper early B-cell development commitment to the lineage. Here we reveal a new role in T-lymphocyte development. Loss of activity results partial block at earliest stage T-lineage This T-cell phenotype precedes lymphoma which occurs between 3 9 months age. thymomas monoclonal highly malignant display cell surface similar that immature thymocytes. In addition, generally express high levels c-myc. As assayed by comparative genomic...
Single-cell sequencing analyses reveal changes in B and T cell transcriptional states the context of ulcerative colitis.
Heterogeneity of small intestine intraepithelial CD8 + T cells suggests functionally distinct subsets RM and their precursors.
The transcription factors encoded by the E2A and early B cell factor (EBF) genes are required for proper development of lymphocytes. However, absence lineage cells in E2A- EBF-deficient mice has made it difficult to determine function or relationship between these proteins. We report identification a novel model system which role EBF regulation multiple traits can be studied. found that conversion 70Z/3 pre-B lymphocytes with macrophage-like phenotype is associated loss EBF. Moreover, we...
Pbx1 is a homeodomain transcription factor that has the ability to form heterodimers with proteins encoded by homeotic selector (Hox) gene complexes and increase their DNA-binding affinity specificity. A current hypothesis proposes interactions are necessary for Hox regulate downstream target genes in turn control growth, differentiation morphogenesis during development. In pre B cell leukemias containing t(1;19) chromosome translocation, converted into strong transactivator fusion...