A5101459240- Skin and Cellular Biology Research
- Virus-based gene therapy research
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Autism Spectrum Disorder Research
- Silk-based biomaterials and applications
- Brucella: diagnosis, epidemiology, treatment
- Liver Diseases and Immunity
- Digestive system and related health
- Inflammatory Bowel Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Nuclear Structure and Function
- Salmonella and Campylobacter epidemiology
- Family and Disability Support Research
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Hair Growth and Disorders
- Dermatological and Skeletal Disorders
- Cancer Cells and Metastasis
- Genetics and Neurodevelopmental Disorders
- Protease and Inhibitor Mechanisms
- Neurogenetic and Muscular Disorders Research
- Immunodeficiency and Autoimmune Disorders
University of Chicago
1992-2024
Nanjing Maternity and Child Health Care Hospital
2018
Nanjing Medical University
2018
University of Chicago Medicine Comprehensive Cancer Center
2017
Howard Hughes Medical Institute
1992-1995
Keratin 5 and keratin 14 have been touted as the hallmarks of basal networks all stratified squamous epithelia. Absence K14 gives rise to epidermolysis bullosa simplex, a human blistering skin disorder involving cytolysis in layer epidermis. To address puzzling question why this disease is primarily manifested rather than other epithelia, we ablated gene mice examined various tissues expressing gene. We show that key factor presence another keratin, K15, which was hitherto unappreciated cell...
Tumor necrosis factor alpha (TNF alpha) orchestrates a wide range of effects that combat severe infections in animals. At lower levels, TNF plays an important protective role stimulating chemotaxis and antimicrobial activity neutrophils, macrophages, eosinophils. During chronic illness, secretion can be elevated markedly, giving rise to cachexia, hemorrhage, and, ultimately, death. Although may mediate many its through 30% injected into animals concentrates the skin. In recent years, it has...
Myosin light chain kinase (MLCK) is expressed as long and short isoforms from unique transcriptional start sites within a single gene. Tumor necrosis factor (TNF) augments intestinal epithelial MLCK expression, which critical to cytoskeletal regulation. We found that TNF increases mRNA transcription, both in human enterocytes vitro murine vivo.5'-RACE identified two novel exons, 1A 1B, encode alternative sites. Chromatin immunoprecipitation (ChIP) site-directed mutagenesis essential Sp1...
Abstract Background Ozanimod regulates lymphocyte egress from the spleen and lymph nodes into systemic circulation. The histologic changes which occur in of patients on these therapies is unknown. We describe with UC who were treated ozanimod underwent subsequent colectomy due to treatment-refractory disease. Methods This retrospective study included undergoing total for disease within 2 months prior a cohort did not have exposure. Histology mesentery specimens reviewed blindly by...
Summary Molecular components of the Brucella abortus cell envelope play a major role in its ability to infect, colonize and survive inside mammalian host cells. In this study, we have defined for conserved gene unknown function B. stress resistance infection. Expression gene, which name eipA, is directly activated by essential cycle regulator, CtrA. eipA encodes soluble periplasmic protein that adopts an unusual eight-stranded β-barrel fold. Deletion attenuates replication survival...
Rett syndrome (RTT), which is a progressive neurodevelopmental disorder characterized by early neurological regression, severely affects cognitive function, as well motor and language skills. Mutations in the methyl-CpG-binding protein 2 (MECP2) gene have been found most patients with typical RTT. In this study, female patient severe symptoms was diagnosed RTT according to revised diagnostic criteria. Genetic analysis reveals that child had novel frameshift mutation, c.368delA...