A5067087345- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Inflammatory Bowel Disease
- Immune cells in cancer
- Cancer-related molecular mechanisms research
University of California, San Diego
2020-2023
Single-cell sequencing analyses reveal changes in B and T cell transcriptional states the context of ulcerative colitis.
During an immune response to microbial infection, CD8+ T cells give rise short-lived effector and memory that provide sustained protection. Although the transcriptional programs regulating cell differentiation have been extensively characterized, role of long noncoding RNAs (lncRNAs) in this process remains poorly understood. Using a functional genetic knockdown screen, we identified lncRNA Malat1 as regulator terminal (t-TEM) circulating subset. Evaluation chromatin-enriched lncRNAs...
Abstract Tissue-resident memory CD8 +T (T RM) cells are a subset of T positioned at barrier sites, critical for host defense against infection. Recent studies have begun to reveal substantial heterogeneity in RMpopulations across different tissues. The gut consists four anatomically distinct compartments, the epithelia and lamina propria small intestine (siIEL, siLPL) colon (cIEL, cLPL). While RMin well-described, findings often generalized whole gut, thus obscuring potential differences...