A5058906211- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
University of California, San Diego
2021-2025
Imperial College London
2018
Adoptive T cell therapies (ACTs) hold great promise in cancer treatment, but low overall response rates patients with solid tumors underscore remaining challenges realizing the potential of this cellular immunotherapy approach. Promoting CD8+ adaptation to tissue residency represents an underutilized promising strategy improve tumor-infiltrating lymphocyte (TIL) function. Here, we report that deletion HIF negative regulator von Hippel-Lindau (VHL) cells induced HIF-1α/HIF-2α-dependent...
Tissue-resident memory CD8 T (TRM) cells provide protection from infection at barrier sites. In the small intestine, TRM are found in least two distinct subpopulations: one with higher expression of effector molecules and another greater potential1. However, origins this diversity remain unknown. Here we proposed that tissue niches drive phenotypic heterogeneity cells. To test this, leveraged spatial transcriptomics human samples, a mouse model acute systemic viral newly established strategy...
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated improved clinical outcomes. However, the cellular interactions that program differentiation function not well understood. Using murine genetic models targeted spatial transcriptomics, we found CD8+ cell–derived chemokine XCL1 is critical for formation conventional DC1 (cDC1) supported positioning of intestinal...
Tissue-resident memory CD8 T cells (T RM ) kill infected and recruit additional immune to limit pathogen invasion at barrier sites. Small intestinal (SI) consist of distinct subpopulations with higher expression effector molecules or greater potential. We hypothesized that occupancy diverse anatomical niches imprints these transcriptional programs. leveraged human samples a murine model acute systemic viral infection profile the location transcriptome pathogen-specific cell differentiation...
Abstract Tissue-resident memory CD8 +T (T RM) cells are a subset of T positioned at barrier sites, critical for host defense against infection. Recent studies have begun to reveal substantial heterogeneity in RMpopulations across different tissues. The gut consists four anatomically distinct compartments, the epithelia and lamina propria small intestine (siIEL, siLPL) colon (cIEL, cLPL). While RMin well-described, findings often generalized whole gut, thus obscuring potential differences...
<h3>Background</h3> CD8<sup>+</sup> T cells are a critical component of the immune response to intracellular infections and malignancies. Recently, tissue-resident memory (Trm) have been shown provide first line defense against reinfection at barrier tissues such as intestine. However, transcriptional networks regulating tissue-adaptation processes incompletely understood. Here, we sought define orchestration small intestinal Trm cells. <h3>Methods</h3> To identify gene-expression...