A5061200907- Neutropenia and Cancer Infections
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- Immune Response and Inflammation
- T-cell and B-cell Immunology
University of California, San Diego
2025
Medizinische Hochschule Hannover
1990-1996
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated improved clinical outcomes. However, the cellular interactions that program differentiation function not well understood. Using murine genetic models targeted spatial transcriptomics, we found CD8+ cell–derived chemokine XCL1 is critical for formation conventional DC1 (cDC1) supported positioning of intestinal...
Granulocyte colony-stimulating factor (G-CSF) was previously shown to be produced constitutively by malignant epithelial cells and monocytes/macrophages, fibroblasts endothelial following stimulation. In this study we investigated the ability of medulloblastoma cells, representing embryonal neuroectodermal produce G-CSF. Conditioned medium freshly prepared from unstimulated explanted tumor tissue two patients with as well cell lines TE-671 DAOY, controls normal glial cells. Following 72...