A5051231707- Monoclonal and Polyclonal Antibodies Research
- Cancer Risks and Factors
- vaccines and immunoinformatics approaches
- Esophageal Cancer Research and Treatment
- Advanced Biosensing Techniques and Applications
- Health disparities and outcomes
- Endometrial and Cervical Cancer Treatments
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Galectins and Cancer Biology
- Global Health Care Issues
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Multiple and Secondary Primary Cancers
- Blood Pressure and Hypertension Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism, Diabetes, and Cancer
- Global Cancer Incidence and Screening
- Coffee research and impacts
- Sodium Intake and Health
- Immune cells in cancer
- S100 Proteins and Annexins
- Genetic Associations and Epidemiology
- Spaceflight effects on biology
First Affiliated Hospital of Zhengzhou University
2023-2025
Zhengzhou University
2018-2023
Nanjing University of Aeronautics and Astronautics
2022-2023
Second Affiliated Hospital of Zhengzhou University
2019-2023
This study aimed to assess the association between obesity, sarcopenia, and sarcopenic obesity with hypertension explore potential mediation of inflammation indicators insulin resistance. Data from UK Biobank, a large-scale prospective cohort, were utilized. Obesity was defined using percentage fat mass, while sarcopenia as low muscle mass strength. The primary outcome assessed new-onset within 5-year follow-up period. analysis examined Cox regression model. A total 183,091 participants...
Metabolic risks are significant factors associated with colorectal cancer. This study aimed to assess global, regional and national burden for CRC attributable metabolic from 1990 2021 predict mortality by 2046. Data the Global Burden of Disease Study were used quantify deaths, disability-adjusted life years (DALYs), age-standardized rates due risk factors, disaggregated sex, age, region, country/territory, sociodemographic index (SDI). The average annual percentage change (AAPC) was analyze...
Abstract Drug resistance is a major barrier in cancer treatment and anticancer drug development. Growing evidence indicates that non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), long (lncRNAs) circular (circRNAs), play pivotal roles progression, therapy, resistance. Furthermore, ncRNAs have been proven to be promising novel therapeutic targets for treatment. Reversing dysregulated by drugs holds significant potential as an effective strategy overcoming Therefore, we developed...
Immunosuppression is a significant factor contributing to the poor prognosis of cancer. S100P, member S100 protein family, has been implicated in various cancers. However, its role tumor microenvironment (TME) pancreatic cancer remains unclear. This study aimed investigate potential impact S100P on TME characteristics patients with cancer.Multiple data (including microarray, RNA-Seq, and scRNA-Seq) were obtained from public databases. The expression pattern was comprehensively evaluated...
The identification of the high-efficiency and non-invasive biomarkers for hepatocellular carcinoma (HCC) detection is urgently needed. This study aims to screen out potential autoantibodies tumor-associated antigens (TAAbs) assess their diagnostic value HCC. Fifteen TAAbs were screened from Human Proteome Microarray by 30 HCC sera 22 normal control sera, which eight passed multiple-stage validations ELISA with a total 1625 human serum samples controls (NCs) patients HCC, liver cirrhosis,...
Abstract Aims This study aimed to investigate environmental factors and genetic variant loci associated with hepatocellular carcinoma (HCC) in Chinese population construct a weighted risk score (wGRS) polygenic (PRS). Methods A case–control was applied confirm the single nucleotide polymorphisms (SNPs) variables linked HCC population, which had been screened by meta‐analyses. wGRS PRS were built training sets validation sets. Area under curve (AUC), net reclassification improvement (NRI),...
Various hypertension predictive models have been developed worldwide; however, there is no existing model for among Chinese rural populations.This a 6-year population-based prospective cohort in areas of China. Data was collected 2007-2008 (baseline survey) and 2013-2014 (follow-up from 8319 participants ranging age 35 to 74 years old. Specified gender were established based on multivariate Cox regression, Artificial Neural Network (ANN), Naive Bayes Classifier (NBC), Classification...
With the changes in environmental, medical technique, population structure and national health projects, human mortality rates have undergone great all over world. According to "World Health Statistics 2016: Monitoring for SDGs (Sustainable Development Goals)", we can draw a globally vision about life expectancy cause of death; also, significant inequality still persists within among countries. This study was designed research into trend pattern China, evaluate disparities age-specific...
Malignant tumors of reproductive system seriously threaten women's life and health. We analyzed the changes in mortality disease burden cervical cancer, uterine cancer ovarian China from 2006 to 2020 provide a basis for formulating scientific prevention control measures.Annual death data were collected Chinese Cause Death Surveillance. The crude rate (CMR), age-standardized (ASMR), annual percentage change (APC), average APC (AAPC) applied analyze trend mortality. Loss expectancy (LLE) years...
Previous studies have demonstrated that autoantibodies against tumor-associated antigens (TAAs) in patients with cancer can be used as sensitive immunodiagnostic biomarkers for the detection of cancer. Most these TAAs are involved tumorigenesis pathway. Cancer driver genes intragenic mutations promote tumorigenesis. This study aims to identify encoded by sera potential gastric adenocarcinoma (GAC).Protein arrays based on were customized screening candidate 100 GAC and 50 normal control (NC)...
Oral cancer is one of the most common cancers in China and seriously threaten life health Chinese people. We analysed trends disparities oral mortality rates disease burden from 2006 to 2021 provide a reference for its prevention control. Annual death data was gleaned Death Surveillance Database. The age-standardized rate (ASMR), annual percentage change (APC), average APC (AAPC) were used analyze trend mortality. Loss expectancy (LLE) years lost (YLL) adopted assess burden. From 2021,...
The serological biomarkers as noninvasive tests are the most promising way for diagnosing gastric cancer (GC). Serological proteome analysis (SERPA) has been used to identify tumor-associated antigens (TAAs) and corresponding autoantibodies in many studies. To explore relationship between development serum autoantibody anti-GRP78 response found by method of SERPA with GC cell line AGS, we included two cohorts (133 133 normal individuals test group; 300 validation group) patients newly...
Long-term isolation is one of the risk factors that astronauts will encounter in spaceflight. At present, few researches have explored DNA methylation dynamics during long-term isolation. In this study, using time series data from "Mars-500" mission, we conducted a multi-step analysis to investigate characteristics and dynamic patterns as well their functional insights The results showed genome-wide changes were minimal. six identified patterns, most significantly fluctuating CpG sites could...
Liver diseases are the serious cause of death in China. We aim to describe trends and disparities major liver disease mortality rates loss life expectancy (LLE) China.Annual percentage change (APC) average APC (AAPC) were calculated using Joinpoint regression model. LLE was eliminated table.From 2006 2017, overall age-standardized rate (ASMR) cirrhosis lightly declined (AAPC: -2.97%), whereas ASMR viral hepatitis cancer remained stable. Viral -4.36%) -4.35%) ASMRs both for females. The...
Esophageal cancer is one of the most commonly diagnosed malignant gastrointestinal tumors. The aim study was to explore diagnostic values anti-POSTN and anti-TIMP1 autoantibodies in esophageal squamous cell carcinoma (ESCC). Differentially expressed genes (DEGs) associated with were screened out by LIMMA method Gene Expression Profiling Interactive Analysis (GEPIA) platform. Search Tool for Retrieval Interacting Genes (STRING) used construct protein-protein interaction (PPI) based on highly...
Abstract Background Chinese women account for 17.51% of the world's deaths because malignant tumors reproductive system, which is a serious threat to women's life and health. We analyzed changes in mortality disease burden cervical cancer, uterine cancer ovarian China from 2006 2020 provide basis formulating scientific prevention control measures. Methods Annual death data were collected Cause Death Surveillance. The crude rate (CMR), age-standardized (ASMR), annual percentage change (APC),...