A5100391101- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Diet and metabolism studies
- Inflammatory Biomarkers in Disease Prognosis
- Pregnancy and preeclampsia studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Risks and Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cervical Cancer and HPV Research
- Metabolism, Diabetes, and Cancer
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Pain Mechanisms and Treatments
- Diabetes and associated disorders
- Lipid metabolism and disorders
- Birth, Development, and Health
- Chronic Kidney Disease and Diabetes
- Gut microbiota and health
- Nutritional Studies and Diet
- Thyroid and Parathyroid Surgery
- Adipose Tissue and Metabolism
Shandong First Medical University
2020-2025
Peking University
2017-2025
Hospital of Hebei Province
2023-2025
Peking University Cancer Hospital
2021-2025
Helmholtz Zentrum München
2024-2025
Center for Environmental Health
2025
Shanxi Medical University
2020-2025
Second Hospital of Shanxi Medical University
2025
Beijing Tongren Hospital
2017-2025
Capital Medical University
1999-2025
China had proposed the unification of equity and efficiency since launch new round health system reform in 2009. And central government gave priority to development primary care (PHC) whilst ensuring its availability improving efficiency. This study aimed evaluate changes PHC resource allocation (PHCRA) explored ways improve current situation. The data this came from Health Statistical Yearbook (2013–2017) (2017). Three five indicators were used measure efficiency, respectively. Lorenz...
Diabetes mellitus ranks high on the international health agenda as a global pandemic and threat to human economies. A total of 10851 participants aged over 40 years were included in cross-sectional analysis. This observational study analyzed prevalence diabetes awareness, treatment glycemic control rural Chinese population. Approximately 25% middle-aged elderly residents had 2010–2011. The was higher with older age, dyslipidemia, body mass index larger waist circumference. Among subjects...
Previous studies have reported an association between sarcopenia and type 2 diabetes mellitus (T2DM), but causation was prone to confounding factors. A more robust research approach is urgently required investigate the causal relationship T2DM.The bi-directional two-sample MR study carried out in two stages: Sarcopenia-related traits were investigated as exposure while T2DM outcome first step, whereas second step reversed. The GWAS summary data for hand-grip strength (n = 256,523),...
Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute the only medication class that consistently prevents or attenuates human heart failure (HF) independent of ejection fraction. We have suggested earlier protective mechanisms SGLT2i Empagliflozin (EMPA) are mediated through reductions in sodium hydrogen exchanger 1 (NHE1)-nitric oxide (NO) pathway, SGLT2. Here, we examined role SGLT2, NHE1 and NO a murine TAC/DOCA model HF. SGLT2 knockout mice showed attenuated systolic dysfunction...
Abstract Aim Insulin resistance (IR) may participate in the pathogenesis of hypertension by mediating low-grade systemic inflammation. The triglycerides-glucose (TyG) index has recently been suggested as a reliable alternative biochemical marker IR compared with traditional methods. Herein, we speculated TyG also be associated hypertension. Methods Data adults were extracted from China Health and Nutrition Survey (CHNS) 2009–2015 this retrospective cohort study. was calculated using formula:...
Backgrounds/Aims: Pericyte loss, vasoregression and neuroglial activation are characteristic changes in incipient diabetic retinopathy. In this study, the effect of antioxidant antiglycating dipeptide carnosine was studied on development experimental Materials/Methods: STZ-induced Wistar rats were orally treated with (1g/kg body weight/day). Retinal vascular damage assessed by quantitative morphometry. protein extracts analyzed for markers oxidative stress, AGE-formation, hexosamine pathway...
The atherogenic index of plasma showed to be related with some chronic disease like cardiovascular diseases and atherosclerosis. Body mass which was commonly used in clinical practice is not an accurate predict non-alcoholic fatty liver disease. aim this study investigate the relationship between obese participants.538 subjects were included cross sectional study. Non-alcoholic diagnosed by B-ultrasonography after excluding participants other diseases. classified into three groups: low (<...
Abstract Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during resistance (IR), when signalling is blunted and accompanied by hyperinsulinaemia, the promotion of DNL continues unabated steatosis increases. Here, we show that WD40 repeat-containing protein 6 (WDR6) IR. Mechanistically, WDR6 interacts with beta-type catalytic subunit serine/threonine-protein phosphatase 1 (PPP1CB) to facilitate PPP1CB dephosphorylation at Thr316, which subsequently...
Abstract Background Trastuzumab is the only first-line treatment targeted against human epidermal growth factor receptor 2 (HER2) approved for patients with HER2-positive advanced gastric cancer. The impact of metabolic heterogeneity on trastuzumab efficacy remains unclear. Methods Spatial metabolomics via high mass resolution imaging spectrometry was performed in pretherapeutic biopsies cancer a prospective multicentre observational study. spectra, representing within tumour areas, were...
Fee for services (FFS) is the prevailing method of payment in most Chinese public hospitals. Under this retrospective system, medical care providers are paid based on and tend to over-treat maximize their income, thereby contributing rising costs uncontrollable health expenditures a large extent. Payment reform needs be promptly implemented move prospective plan. The diagnosis-related group (DRG)-based case-mix with its superior efficiency containment costs, has garnered increased attention...
Abstract Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) co-producing bla KPC and NDM poses a serious threat to public health. This study aimed investigate the mechanisms underlying resistance virulence of CR-hvKP isolates collected from Chinese hospital, with focus on dual-positive hvKP strains. Methods Five strains were isolated teaching hospital in China. Antimicrobial susceptibility plasmid stability testing, conjugation, pulsed-field gel electrophoresis,...
Purpose: Cucurbitacins, which are found in a variety of medicinal plants, vegetables and fruits, were known for their diverse pharmacological biological activities, including anticancer, anti-oxidative anti-inflammatory effects. Cucurbitacin E, one the major cucurbitacins, was recently proved to inhibit inflammatory response. Methods: To explore therapeutic effects cucurbitacin E on colitis underlying mechanisms, male mice drunk water containing 2.5% dextran sulfate sodium (DSS) establish...
Insufficient evidence is available to reliably compare the roles of bone alkaline phosphatase (BAP) and mineral density (BMD) in diabetes. This study aimed associations between BAP BMD adults with without diabetes elucidate fracture risk Data were extracted from National Health Nutrition Examination Survey (NHANES), 2001–2004, including 4197 aged 20 49 years, 143 (DM group), 4054 (non-DM group). Main outcome measure was regression analyses performed identify serum other covariates associated...
Elucidating the normal structure and distribution of cerebral vascular system is fundamental for understanding its function. However, studies on visualization whole-brain quantification vasculature with cellular resolution are limited. Here, we explored at level using newly developed CLARITY technique. Adult male C57BL/6J mice undergoing transient middle artery occlusion Tie2-RFP transgenic were used. Whole mouse brains extracted processing. Immunostaining was performed to label vessels....
Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule subclinical hypothyroidism (SCH). L-thyroxine replacement therapy (LRT) usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid mild people could also benefit from LRT. However, the benefits were different among individuals, as shown by variations drug dosage required to maintain TSH stability. Alternative pathways, such sulfation glucuronidation...