A5047954683- Genetic Associations and Epidemiology
- Estrogen and related hormone effects
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Psoriasis: Treatment and Pathogenesis
- Hormonal and reproductive studies
- Pesticide and Herbicide Environmental Studies
- Weed Control and Herbicide Applications
- Pharmacogenetics and Drug Metabolism
- Phytochemistry and biological activity of medicinal plants
- Ginseng Biological Effects and Applications
- Cardiac Health and Mental Health
- Effects and risks of endocrine disrupting chemicals
- Salivary Gland Disorders and Functions
- Traditional Chinese Medicine Analysis
- Cardiovascular Function and Risk Factors
- Urologic and reproductive health conditions
- Multiple Sclerosis Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Maternal and fetal healthcare
- Contact Dermatitis and Allergies
- Virus-based gene therapy research
- Ectopic Pregnancy Diagnosis and Management
- Environmental remediation with nanomaterials
- Biological and pharmacological studies of plants
Shandong Provincial Hospital
2017-2025
Shandong First Medical University
2021-2025
Shandong University
2017-2024
Shantou University
2023-2024
Shantou University Medical College
2023-2024
Peking University Shenzhen Hospital
2023
Shandong Academy of Sciences
2023
Qilu University of Technology
2023
Affiliated Hospital of Southwest Medical University
2022
Shandong Academy of Chinese Medicine
2017
The diagnosis of ovotesticular disorders sex development can only be confirmed when both testicular and ovarian tissues are present simultaneously in the same individual, regardless patient's karyotype. This report aims to discuss treatment a rare case complicated by dysgerminoma. patient, 24-year-old female, was admitted hospital due clitoral hypertrophy. Chromosomal analysis revealed chimeric karyotype 46, XX/46, XY. Biopsies ovaries indicated presence dysgerminoma right tissue....
Abstract Observational studies have found a potential bidirectional positive association between multiple sclerosis and psoriasis, but these are susceptible to confounding factors. We examined the directionality of causation using Mendelian randomization estimated genetic correlation linkage disequilibrium score. performed analysis large-scale genome-wide datasets from International Multiple Sclerosis Genetics Consortium (IMSGC, 115,803 individuals European ancestry) FinnGen (252,323...
Vitiligo is caused by melanocyte depletion. Studies have suggested that skin-homing cytotoxic T lymphocytes express cutaneous lymphocyte-associated antigen (CLA) are responsible for The characteristics of these cells not been well established yet. To investigate the frequency CD8(+)T (CD8(+)CLA(+)T cells) and their expression molecules, as migration-related molecules in cell non-segmental vitiligo patients. CD8(+)CLA(+)T (perforin, granzyme-B FasL) peripheral blood patients with were...
Endocrine disruptors as risk factors for endometrial cancer (EC) are positively correlated with serum follicle-stimulating hormone (FSH) levels. Additionally, increased FSH is associated EC. However, its exact mechanism not yet clear. Therefore, this study investigated how affects the occurrence of Using immunohistochemistry (IHC), immunofluorescence (IF), and Western blot (WB), we found that receptor (FSHR) was expressed in both EC tissues cell lines. To explore effect on vitro, Ishikawa...
1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol the family thymelaeaceae, has chemical structure similar to several potent COMT reported previously. Here potential daphnetin its Phase II metabolites as was investigated with human liver cytosol (HLC). 2. Daphnetin methylated metabolite (8-O-methyldaphnetin) were found inhibit COMT-mediated dopamine O-methylation in dose-dependent...
There is a paucity of experimental data regarding dioxin-like toxicity polybrominated dibenzo-p-dioxins/dibenzofurans (PBDD/Fs) and non-ortho biphenyls (PBBs). In this study, avian aryl hydrocarbon receptor 1 (AHR1)-luciferase reporter gene assays were used to determine their species-specific potencies (DLPs) congener-specific interspecies relative sensitivities in birds. The results suggested that DLPs the brominated congeners for chicken-like (Ile324_Ser380) species did not always follow...
Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by exocrine and extra-glandular symptoms. The literature indicates that SS an independent risk factor for atherosclerosis (AS); however, its pathophysiological mechanism remains undetermined. This investigation aimed to elucidate the crosstalk genes pathways influencing pathophysiology of AS via bioinformatic analysis microarray data.Microarray datasets (GSE40611) (GSE28829) were retrieved from Gene Expression Omnibus...
Although observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous.We conducted two-sample Mendelian randomization (MR) study to analyze between TIA and CAD using data from FinnGen genome-wide association study. Analysis was performed inverse-variance weighted (IVW) method. The robustness results evaluated MR-Egger regression, median, MR pleiotropy residual sum,...
Observational studies have reported the association between fatigue and coronary artery disease (CAD), but causal CAD is unclear.We conducted a bidirectional Mendelian randomization (MR) study using publicly available genome-wide (GWAS) data. The inverse-variance weighted (IVW) method was used as primary analysis. We performed three complementary methods, including median, MR-Egger regression, MR pleiotropy residual sum outlier (MR-PRESSO) to evaluate sensitivity horizontal of...
Abstract Background Observational studies have showed an association between schizophrenia and risk of psoriasis vice versa. However, whether is causally associated with unclear. Method s A two‐sample bidirectional Mendelian randomization (MR) analysis was performed publicly available genome‐wide study data including ( n = 77 096) 462 933). The inverse‐variance weighted method as the main analysis, a complementary other two analyses: MR‐Egger median method. series sensitivity analyses were...
Abstract The training of deep convolutional neural networks requires a substantial amount labeled data. Nevertheless, the available kinds labels that are implemented currently to segment medical images cause high-quality image annotations bring costly and time-consuming procedures. Moreover, distinct modalities such as CT MRI-based cardiac make it difficult train model. So, one set data in modality cannot be segmented into another efficiently. Thus, an unsupervised domain-adaptive...
Objective: To analyze the distribution and genetic characteristics of sporadic adult diarrhea virus in Chaoyang District, Beijing. Methods: Fecal samples from 177 patients with were collected 4 enteric outpatient clinics Beijing May to December 2019. Nucleic acid detection Norovirus, Sappovirus, Rotavirus, Enteric Adenovirus Astrovirus was performed by real-time quantitative PCR. The positive amplified RT-PCR/PCR sequenced. phylogenetic analysis neighbor-Joining (NJ) methods Mega 6.0...
Objective To evaluate the effect of salicylic acid on skin barrier function and efficacy combined with flumetasone ointment for treatment atopic dermatitis (AD).Methods Sixtyfour patients AD (including 31 males 33 females) aged 18 to 58 years were recruited into present study.Four lesional areas similar size severity selected at body sites both sides each patient,and randomly classified four groups be topically treated compound (containing 0.02％ 3％ acid,compound group),flumetasone...