A5068100608- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- Growth Hormone and Insulin-like Growth Factors
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Peroxisome Proliferator-Activated Receptors
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Vitamin D Research Studies
- Cholesterol and Lipid Metabolism
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Prostate Cancer Treatment and Research
- Bacterial Infections and Vaccines
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Sulfur Compounds in Biology
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Ovarian function and disorders
- Bacterial Genetics and Biotechnology
- Cell death mechanisms and regulation
Shandong Provincial Hospital
2016-2025
Shandong Academy of Chinese Medicine
2015-2025
Shandong First Medical University
2014-2025
Shandong Center for Disease Control and Prevention
2023-2025
Tianjin Hospital
2025
Tianjin University
2025
First Affiliated Hospital of Jiangxi Medical College
2025
Jiangxi Provincial People's Hospital
2025
Shandong University
2015-2024
Southern Medical University
2024
Objective Systemic immune-inflammation index (SII), a novel inflammatory indicator based on platelets, neutrophils and lymphocytes, has been shown to be associated with prognostic value in several solid tumors. However, its nonalcoholic fatty liver disease (NAFLD) not reported yet. Therefore, the present study aimed investigate of SII individuals NAFLD.Methods Data was collected from 2005 2014 National Health Nutrition Examination Survey (NHANES, https://www.cdc.gov/nchs/nhanes/index.htm),...
Elevated thyroid-stimulating hormone (TSH) and hypercholesterolemia commonly coexist, as typically seen in hypothyroidism, but there is no known mechanism directly linking the two. Here, we demonstrated that liver cells, TSH promoted expression of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR), a rate-limiting enzyme cholesterol synthesis, by acting on receptor hepatocyte membranes stimulating cyclic adenosine monophosphate / protein kinase monophosphate–responsive element binding...
Dyslipidemia in thyroid dysfunction has always been attributed to changes hormone (TH) levels. We hypothesized that TSH plays an important role lipid metabolism independent of TH. conducted a cross-sectional study investigate the relationship between serum levels and profiles after controlling for free T3, T4, total T4 nonthyroid factors relevant euthyroid Chinese subjects. General linear analysis was performed determine whether impact on is TH Moreover, path analysis, evolutionary...
Cholesterol homeostasis is strictly regulated through the modulation of HMG-CoA reductase (HMGCR), rate-limiting enzyme cholesterol synthesis. Phosphorylation HMGCR inactivates it and dephosphorylation activates it. AMP-activated protein kinase (AMPK) major phosphorylating enzyme. Our previous study found that thyroid-stimulating hormone (TSH) increased hepatocytic expression, but was still unclear whether TSH affected hepatic phosphorylation associated with AMPK. We used bovine (bTSH) to...
Objective The objectives of this study were to observe the changes in follicle-stimulating hormone (FSH) and bone mineral density (BMD) postmenopausal women, research relationship between FSH osteoporosis, effects on osteoclast differentiation RAW264.7 cells. Methods We analyzed 248 women with normal metabolism. A radioimmunoassay (RIA) was used detect serum FSH, luteinizing (LH), estradiol (E2). Dual-energy X-ray absorptiometry measure forearm BMD. Then, we age-related LH E2. Additionally,...
Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in the liver, but it was unclear whether there a direct link between TSH, AMPK SREBP-2. Here, we demonstrate 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced activation of directly inhibited SREBP-2 its target genes HMGCR HMGCS, which are key enzymes cholesterol biosynthesis,...
Objective To evaluate the relationship between serum total testosterone (TT) level and lipid profile after adjusting for some traditional confounding factors, free thyroid hormones TSH in Chinese men. Methods This was a retrospective study based on an epidemiological investigation including 11 000 subjects. Bivariate partial correlation analysis, multiple linear regression general model were used to assess influence of TT profile. Additionally, odds ratios (ORs) (95% CIs)...
Obesity, which is related to increased oxidative stress in various tissues, a risk factor for male infertility. Metformin reported have an antioxidant effect; however, the precise role of metformin obesity-induced infertility remains unknown. The current study aimed at exploring effects and characterizing its underlying mechanism fertility obese males. An mouse model was generated by feeding mice with high-fat diet; then, were administered water 8 weeks. Reproductive ability, metabolic...
Introduction Age-related decline in testosterone is associated with Leydig cell aging impaired synthesis aging. Obesity accelerates the age-related testosterone. However, mechanisms underlying and effects of obesity on remain unclear. Method Natural mice diet-induced obese were used to assess process testicular senescence age or obesity. Bioinformatic analysis young aged human testes was explore key genes related cell-specific p38 MAPK knockout (p38LCKO) further analyze roles The levels...
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic triglyceride accumulation, ranging from steatosis to steatohepatitis and cirrhosis. NAFLD a risk factor for cardiovascular diseases associated with metabolic syndrome. Antihyperlipidemic drugs are recommended as part of the treatment patients. Although fibrates activate peroxisome proliferator-activated receptor α (PPARα), leading reduction serum levels, effects these on remain controversial. Clinical studies have reported...
Thyroid hormones disorders are associated with changes of body composition. However, the relationship between thyroid and fat in a euthyroid population is unclear. The aim this study was to explore association euthyriod population.A total 865 individuals were recruited study. Subjects diseases or diabetes who taking medications that could influence hormones, weight glucose metabolism excluded.FT3, FT4, lipid parameters, fasting insulin (FINS) blood determined, homeostasis model assessment...
Epidemiological evidence indicates that thyrotropin (TSH) is positively correlated with the severity of obesity. However, mechanism remains unclear. Here, we show TSH promoted triglyceride (TG) synthesis in differentiated adipocytes a thyroid hormone-independent manner. Mice subclinical hypothyroidism, which characterized by elevated serum but not hormone levels, demonstrated 35% increase total white adipose mass compared their wild-type littermates. Interestingly, Tshr KO mice, had normal...
Increasing evidence shows that subclinical hypothyroidism (SCH) is associated with atherosclerosis (ATH), but the association remains controversial. MicroRNAs (miRNAs) have been proved to be involved in and dyslipidemia as gene regulators.The objective of study was determine expression profiles six serum miRNAs critical SCH patients reanalyze between from a new perspective. OUTCOMES, DESIGN, AND PARTICIPANTS: MicroRNA profiling analysis performed by real-time PCR normal control subjects (NC;...
Physiological opening of the mitochondrial permeability transition pore (mPTP) is indispensable for maintaining function and cell homeostasis, but role mPTP its initial factor, cyclophilin D (CypD), in hepatic steatosis unclear. Here, we demonstrate that excess mediated by an increase CypD expression induced dysfunction. Notably, such perturbation occurred before detectable triglyceride accumulation liver high‐fat diet–fed mice. Moreover, either genetic knockout or pharmacological inhibition...
Emerging epidemiological studies indicate that hypercholesterolaemia is a risk factor for testosterone deficiency. However, the underlying mechanism unclear. Testicular Leydig cells are primary source of in males. To identify effect and cholesterol overload on cell function, rats were fed with HC (HC) diet to induce hypercholesterolaemia. During 16-week feeding period, serum levels reduced time-dependent manner diet. Accordingly, these steroidogenic enzymes within cells, including acute...
Lateral patellar compression syndrome (LPCS) is a common cause of anterior knee pain. Early diagnosis LPCS using an accurate radiological examination is, therefore, important. However, the currently used examinations for detecting are poor diagnostic indicators. Therefore, aim this study was to establish new imaging and evaluate its accuracy in comparison with conventional examinations. From June 2020 May 2023, retrospective analysis conducted on 72 patients group 140 Control group, all whom...