A5100623747- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Thyroid Disorders and Treatments
- Autophagy in Disease and Therapy
- Obstructive Sleep Apnea Research
- Gallbladder and Bile Duct Disorders
- Chronic Kidney Disease and Diabetes
- TGF-β signaling in diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Diet and metabolism studies
- Osteoarthritis Treatment and Mechanisms
- Legionella and Acanthamoeba research
- Hedgehog Signaling Pathway Studies
- Crustacean biology and ecology
- Transcranial Magnetic Stimulation Studies
- Skin and Cellular Biology Research
- Connective Tissue Growth Factor Research
- Eosinophilic Disorders and Syndromes
- Quinazolinone synthesis and applications
Shandong First Medical University
2019-2024
Shandong Provincial Hospital
2009-2024
Second Affiliated Hospital of Zhejiang University
2024
Thomas Jefferson University
2024
Jilin University
2022
Union Hospital
2019-2022
Northwest A&F University
2019-2022
Weatherford College
2022
Shandong University
2008-2021
Guangzhou University of Chinese Medicine
2021
Elevated thyroid-stimulating hormone (TSH) and hypercholesterolemia commonly coexist, as typically seen in hypothyroidism, but there is no known mechanism directly linking the two. Here, we demonstrated that liver cells, TSH promoted expression of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR), a rate-limiting enzyme cholesterol synthesis, by acting on receptor hepatocyte membranes stimulating cyclic adenosine monophosphate / protein kinase monophosphate–responsive element binding...
Abstract Triglyceride glucose (TyG) index and inflammatory markers are reported to have a positive association with metabolic syndrome (MetS). However, no previous study has assessed the value of TyG as predictors in same study. This looks at comparison triglyceride blood leukocyte indices Chinese population. The cohort involved 1542 population without syndrome. subjects underwent comprehensive routine health examination 2011 returned for follow-up 2016. Metabolic was defined according...
Objective Polyethylene glycol loxenatide (PEG-Loxe) is a novel, once-weekly glucagon-like peptide 1 receptor agonist that approved in doses of 0.1 mg and 0.2 for the treatment type 2 diabetes mellitus (T2DM). However, no clinical trials have been designed to determine effect 0.3 PEG-Loxe on weight loss overweight or obese patients with T2DM. This trial aimed evaluate short-term PEG-Loxe, injected subcutaneously once weekly, management Methods 16-week, open-label, parallel-arm, randomized,...
The development of acquired resistance to small molecule tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) signaling has hindered their efficacy in treating non-small cell lung cancer (NSCLC) patients. Our previous study showed that constitutive activation the 70 kDa ribosomal protein S6 1 (S6K1) contributes EGFR-TKIs NSCLC lines and xenograft tumors nude mice. However, regulatory mechanisms underlying S6K1 TKI-resistant cells have not yet been explored. In...
The Malayan pangolin ( Manis javanica ) is an unusual, scale-covered, toothless mammal that specializes in myrmecophagy. Due to their threatened status and continuing decline the wild, concerted efforts have been made conserve rescue this species captivity China. Maintaining a significant challenge, partly because little known of molecular mechanisms its digestive system. Here, first large-scale sequencing analyses salivary gland, liver small intestine transcriptomes adult M. genome were...
Autophagy has been demonstrated to play important roles in the infection and pathogenesis of many viruses. We previously found that porcine parvovirus (PPV) can induce autophagy placental trophoblast cells (PTCs), but its underlying mechanism not yet fully revealed. In this study, we showed PPV inhibited activation mTORC1 promoted expression Beclin 1 LC3II PTCs. Treatment with a mTOR activator LC3II, as well formation, reduced viral replication PPV-infected Furthermore, inhibition AMPK...
Abstract Significant evidence demonstrates that oxidative stress can impair insulin secretion and contribute to the development of type 2 diabetes. Branched‐chain amino acids (BCAAs) are reported be positively related secretion. This study aimed determine how affects function islets whether BCAAs ameliorate stress, accompanying c‐jun N‐terminal kinase (JNK), protein D1 (PKD1), pancreatic/duodenal homeobox‐1 (PDX‐1) changes induced by streptozotocin (STZ). Plasma glucose, plasma insulin, JNK,...
Autophagy plays important roles in the infection and pathogenesis of many viruses, yet regulatory autophagy process porcine parvovirus (PPV) remain unclear. Herein, we show that PPV induces placental trophoblasts (PTCs). Induction by rapamycin (RAPA) inhibited occurrence apoptotic cell death, promoted viral replication PPV-infected cells; inhibition 3-MA or ATG5 knockdown increased cellular apoptosis reduced replication. Interestingly, found presence caspase-inhibitor zVAD-fmk, non-apoptotic...
Given the universal presence of antagonism between arginine and lysine, determining optimal dietary arginine/lysine level is great importance. In this study, eight diets were formulated to contain different level, followed by a 9-week feeding trial with shrimps 2.10 ± 0.01 cm in length 0.38 0.02 g weight determine effect on growth performance, body composition enzyme activity. The results showed that Diet 6 (arginine/lysine 29.4/21.0 g/kg) group had significantly higher gain rate, specific...
Abstract Flavonoid glycoside scutellarin (SCU) has been widely applied in the treatment of cerebral ischemic diseases China. In this article, we conducted research on working mechanisms SCU hypoxia reoxygenation (HR) injury isolated basilar artery (BA) and erebral ischemia reperfusion (CIR) rat models. BA rings, HR causes endothelial dysfunction (ED) acetylcholine (ACh) induces endothelium-dependent vasodilation. The myography result showed that (100 µM) was able to significantly improve...
Abstract The effect of leucine on glucose‐stimulated insulin secretion (GSIS) in pancreatic β‐cells is quite controversial, and mechanism involved the has not been elucidated yet. Consequently, we aimed to investigate GSIS its focusing contribution AMP‐activated protein kinase (AMPK) pancreatic/duodenal homeobox‐1 (PDX‐1). Rat insulinoma (INS‐1, RIN m5F, DN‐PDX‐1#28 PDX‐1#6) were cultured with or without leucine, AICAR (AMPK agonist) compound C antagonist) for 48 hrs. In contrast control,...
Previous studies suggest that postmenopausal osteoarthritis is linked to a decrease in estrogen levels. However, whether follicle-stimulating hormone (FSH), the upstream of estrogen, affects cartilage destruction and thus contributes onset has never been explored. To evaluate potential involvement FSH joint degeneration identify molecular mechanisms through which influences chondrocytes, mouse chondrocytes ATDC5 chondrocyte cell line were treated with inhibitors intracellular signaling...
Obstructive sleep apnea (OSA) syndrome has a negative impact on the health of millions adolescents and youth. The aim this study was to evaluate associations OSA with obesity cardiometabolic risk factors among youth at for metabolic (MS).A total 558 subjects aged 14-28 years were recruited from Beijing Child Adolescent Metabolic Syndrome Study. Each underwent 2-h oral glucose tolerance test (OGTT), echocardiography, liver ultrasonography. Anthropometric measures, blood levels glucose,...
Abstract Although subacute thyroiditis (SAT) is thought to be a self-limited inflammatory thyroid disease, the recurrence rate of SAT approximately 10–20%. It difficult for these patients stop glucocorticoid treatment, and they are usually bothered with recurrent pain side effects glucocorticoids more than several months. We describe three cases who were diagnosed after reduction in prednisolone (PSL) dose, either immediately upon cessation PSL or shortly thereafter. Their symptoms,...
Previous studies have found follicle-stimulating hormone (FSH) receptors on chondrocytes (cartilage cells), but the mechanism of FSH action is not clear. The purpose this experiment to study whether affects and how it causes changes in these cells. Our results show that osteoarthritis became worse after injection knee joint mice. After stimulation by FSH, a total 664 up-regulated genes, such as Col12a1 Col1a1, 644 down-regulated MGP, were screened transcriptomics. A subset extracellular...
Hyperthyroidism is a clinical state that results from increased thyroid hormone levels which has significant impact on cardiac function and structure. Graves’ disease the most common cause of hyperthyroidism in iodine-replete areas. Hyperthyroid heart may be associated with pulmonary hypertension patients who have overt hyperthyroidism. To investigate association induced by hyperthyroid autoantibody, one hundred cases were consecutively admitted to inpatient department endocrinology...