A5012447055- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Zebrafish Biomedical Research Applications
- interferon and immune responses
- Environmental Toxicology and Ecotoxicology
- Aquaculture disease management and microbiota
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Reproductive Biology and Fertility
- Animal Disease Management and Epidemiology
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Viral Infections and Vectors
- Peroxisome Proliferator-Activated Receptors
- Microbial infections and disease research
- Congenital heart defects research
- Nitric Oxide and Endothelin Effects
- Immune cells in cancer
- Circular RNAs in diseases
- Bacteriophages and microbial interactions
Northwest A&F University
2015-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Ministry of Education of the People's Republic of China
2022-2024
Agriculture and Forestry University
2024
Southern Medical University
2024
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
Sichuan Agricultural University
2010-2023
Gannan Normal University
2020-2023
University of California, Davis
2023
Abstract Background Porcine epidemic diarrhea virus (PEDV) is an important pathogen in swine and responsible for substantial economic losses. Previous studies suggest that the PEDV E protein plays role viral assembly process. However, subcellular localization other functions of still require more research. Methods The function were investigated by examining its effects on cell growth, cycle progression, interleukin-8 (IL-8) expression survival. Results results show plenty localized ER, with...
Viruses use diverse strategies to impair the antiviral immunity of host in order promote infection and pathogenesis. Herein, we found that PCV2 promotes DNA viruses through inhibiting IFN-β induction vivo vitro . In early phase infection, phosphorylation cGAS at S278 via activation PI3K/Akt signaling, which directly silences catalytic activity cGAS. Subsequently, can facilitate K48-linked poly-ubiquitination K389, been served as a signal for recognizing by ubiquitin-binding domain histone...
Long noncoding RNAs (lncRNAs) were recently found to be key regulators of biological functions and associated with human diseases. Thus far, the roles lncRNAs in inflammatory bowel disease (IBD) remain unknown. We aimed determine whether are IBD regulate epithelial cell physiology.lncRNAs microarray quantitative RT-PCR performed on 60 sigmoid colon biopsies from patients active ulcerative colitis (UC) relevant controls. Localization was detected by situ hybridization subcellular RNA. The...
Brucella spp. impedes the production of pro-inflammatory cytokines by its outer membrane protein Omp25 in order to promote survival and immune evasion. However, how regulates tumor necrosis factor (TNF-α) expression different mammalian macrophages remains unclear. In this study, we investigated potential mechanisms which TNF-α expression, found that Omp25-deficient mutant B. suis exhibited an enhanced compared with wild-type (WT) suis, whereas ectopic suppressed LPS-induced at both mRNA...
Recent studies have demonstrated that ovarian granular cells (OGCs) pyroptosis is present in the ovaries of polycystic ovary syndrome (PCOS) mice and NLRP3 activation destroys follicular functions. Metformin has been shown to protect against PCOS by reducing insulin resistance women, whereas its role OGC unknown. This study aimed investigate impact metformin on underlying mechanisms. The results showed treating a human granulosa-like tumor cell line (KGN) with significantly decreased...
Swainsonine (1, 2, 8-trihyroxyindolizidine, SW), a natural alkaloid, has been reported to exhibit anti-cancer activity on several mouse models of human cancer and cancers in vivo.However, the mechanisms SW-mediated tumor regression are not clear.In this study, we investigated effects SW lung cell lines vitro.The results showed that significantly inhibited these cells growth through induction apoptosis different extent vitro.Further studies treatment up-regulated Bax, down-regulated Bcl-2...
Carboxin is a heterocyclic systemic fungicide, mainly used to prevent and control grain smut wheat rust. Although its mammalian toxicity has been reported, acute exposure aquatic animals unknown. In our study, we zebrafish as organisms study toxicity. can cause developmental cardiotoxicity in embryos. Histopathological staining of cardiac sections reveals structural changes hearts, fluorescence quantitative PCR results shows the heart genes mRNA expression levels were disrupted...
The mechanism of genome DNA replication in circular single-stranded viruses is currently a mystery, except for the fact that it undergoes rolling-circle replication. Herein, we identified SUMOylated porcine nucleophosmin-1 (pNPM1), which previously reported to be an interacting protein viral capsid protein, as key regulator promotes circovirus. Upon circovirus type 2 (PCV2) infection, SUMO2/3 were recruited and conjugated with K263 site pNPM1’s C-terminal domain SUMOylate pNPM1,...
// Qian Du 1, * , Yong Huang Tongtong Wang 1 Xiujuan Zhang Yu Chen Beibei Cui Delong Li Xiaomin Zhao Wenlong Lingling Chang Dewen Tong College of Veterinary Medicine, Northwest A&F University, Xianyang, Shaanxi, P. R. China These authors have contributed equally to this work Correspondence to: Tong, e-mail: dwtong@nwsuaf.edu.cn Keywords: porcine circovirus type 2, capsid, IL-10, gC1qR, Immunology and Microbiology Section, Immune response, Immunity Received: October 29,...
Transmissible gastroenteritis virus (TGEV) infection can activate NF-κB pathway in porcine intestinal epithelial cells and result severe inflammation. Non-coding RNAs (ncRNAs) are not translated into proteins play an important role many biological pathological processes such as inflammation, viral infection, mitochondrial damage. However, whether ncRNAs participate TGEV-induced inflammation is largely unknown.In this study, the next-generation sequencing (NGS) technology was used to analyze...
Porcine parvovirus (PPV) infection primarily causes reproductive failure of pregnant swine and results in host cell death. Boars, as an important disseminator, shed PPV to sows via semen. infects numerously replicates boar testicle, which damage testicle vivo. Reactive oxygen species (ROS), a mediator apoptosis, play crucial role the mitochondria apoptotic pathway. However, whether induces ST cells apoptosis ROS accumulation is still unclear. To determine effects on we detected morphological...
Famoxadone-cymoxanil is a new protective and therapeutic fungicide, but little research has been done on it or its toxicity in aquatic organisms. In this study, we used zebrafish to investigate the cardiotoxicity of famoxadone-cymoxanil potential mechanisms involved. Zebrafish embryos were exposed different concentrations until 72 h post-fertilization (hpf), then changes heart morphology observed. We also detected levels oxidative stress, myocardial-cell proliferation apoptosis, ATPase...