A5100430224- Zebrafish Biomedical Research Applications
- Environmental Toxicology and Ecotoxicology
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Diabetes and associated disorders
- Mitochondrial Function and Pathology
- Genetic and phenotypic traits in livestock
- Congenital heart defects research
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Breast Cancer Treatment Studies
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Aquaculture disease management and microbiota
- Thyroid Cancer Diagnosis and Treatment
- Animal Nutrition and Physiology
- Diabetes Management and Research
- Meat and Animal Product Quality
- Plant Toxicity and Pharmacological Properties
- Advanced Breast Cancer Therapies
- Tryptophan and brain disorders
- Head and Neck Anomalies
- Breast Implant and Reconstruction
- Gout, Hyperuricemia, Uric Acid
Shandong Academy of Agricultural Sciences
2007-2025
Jinan University
2025
Zigong First People's Hospital
2022-2024
Gannan Normal University
2020-2024
First Affiliated Hospital of Gannan Medical University
2024
Sun Yat-sen University
2023
Peking University Third Hospital
2023
Peking University
2023
Academy of Military Medical Sciences
2023
Chinese People's Liberation Army
2023
This study investigated the effects of Capsicum oleoresin (CAP) on growth performance, nutrient digestibility and meat quality fattening beef cattle. A total 48 Simmental crossbred cattle, selected based body weight (484.7 ± 48.4 kg), were randomly assigned to four treatment groups (each with 12 animals) in a randomized complete block design. In each group, basal diet was supplemented 0 g/d CAP (control), 4 g/d, 8 g/d. The results showed that adding linearly increased dry matter intake (DMI;...
Famoxadone-cymoxanil is a new protective and therapeutic fungicide, but little research has been done on it or its toxicity in aquatic organisms. In this study, we used zebrafish to investigate the cardiotoxicity of famoxadone-cymoxanil potential mechanisms involved. Zebrafish embryos were exposed different concentrations until 72 h post-fertilization (hpf), then changes heart morphology observed. We also detected levels oxidative stress, myocardial-cell proliferation apoptosis, ATPase...
Pendimethalin (PND) is one of the best sellers selective herbicide in world and has been frequently detected water. However, little known about its effects on cardiac development. In this study, we used zebrafish to investigate developmental toxicity PND. We exposed embryos with a serial concentrations at 3, 4, 5 mg/L 5.5–72 h post-fertilization (hpf). found that PND exposure can reduce heart rate, survival body length embryos. Furthermore, identified many malformations including pericardial...
Acenaphthene is a polycyclic aromatic hydrocarbon (PAH) that widely distributed environmental pollutant accumulates in organisms and leads to health risks humans. Although acenaphthene reported be toxic aquatic organisms, its effects of on the livers these have not been evaluated. Here, zebrafish were used as an experimental model. Zebrafish larvae exposed 4.5, 5.5, 6.5 mg/L for 72 h while adult 1.5, 2, 2.5 28 days. We investigated mechanism by which causes liver toxicity zebrafish. The...
Sulfometuron methyl (SM) is a widely used herbicide and thus leading to accumulation in the environment. The toxicity assessments of SM model organisms are currently rare. In present study, zebrafish were utilized for evaluating detrimental effects aquatic vertebrates. Zebrafish embryos exposed 0, 10, 20, 40 mg/L from 5.5 72 h post-fertilization (hpf), respectively. Consequently, exposure resulted increasing mortality rate reducing hatching larval at SM-treated groups. reduced numbers immune...
In recent years, most studies believe that high TSH level is positively correlated with the incidence of thyroid cancer, but it still controversial. For this reason, purpose study to analyze correlation between preoperative and malignant nodules using pathological diagnosis as gold standard. To evaluate role serum in predicting malignancy uncertain cytology.As an important member hypothalamus-pituitary-thyroid axis endocrine system, plays a crucial regulating growth, differentiation,...
Evaluation of the effectiveness melatonin is necessary to prevent development delirium in hospitalized patients. Melatonin (N-acetyl-5-methoxytryptamine) a hormone produced by pineal gland brain from amino acid tryptophan. Synthetic supplements have been used for various medical conditions, especially sleep-related diseases, and proved be successful.To determine effect on prevention patients.A literature search CNKI, Wanfang Database, VIP China Biomedical Literature PubMed, Embase, Cochrane...
Recent population and animal studies have revealed a correlation between fat content the severity of benzene-induced hematologic toxicity. However, precise impact lipid deposition on hematotoxicity underlying mechanisms remain unclear. In this study, we established mouse model with moderate accumulation by subjecting mice to an 8-week high-fat diet (45% kcal from fat, HFD), followed 28-day inhalation benzene at doses 0, 1, 10, 100 ppm. The results showed that exposure caused dose-dependent...
Benoxacor (BN) is a highly effective antidote of dichloroacetamide herbicides generally used to protect crops from herbicidal damage. As commonly agrochemical, this herbicide continuously discharged in watercourses thus causing toxicity aquatic organisms, and ultimately leading contamination the food chain. To date, its potential cardiac development organisms has not been evaluated. In present study, we have selected zebrafish as model study impact BN on embryonic developmental toxicity. The...
Background Pyrotinib, a small-molecule tyrosine kinase inhibitor, has been investigated as component of neoadjuvant therapy in phase 2 trials human epidermal growth factor receptor (HER2)-positive breast cancer. This study aimed to evaluate the effectiveness and safety pyrotinib-containing for patients with HER2-positive early or locally advanced cancer real-world setting. Methods Data 97 from 21 centers across China treated were reviewed. Neoadjuvant consisted taxane/carboplatin/trastuzumab...
Abstract Rationale: Insulin autoimmune syndrome (IAS) is a rare endocrine disease characterized by repeated fasting hypoglycemia or episodes of late after meals, elevated serum insulin, and positivity for insulin autoantibody (IAA) receptor antibody (IRA). We summarize the clinical manifestations treatment experiences 3 patients with IAS. Patient concerns: One patient >20-year history type 2 diabetes mellitus had irregular years insulin. Another 6-year presented 6 months Graves’ showed...
Abstract Rationale: Fulminant type 1 diabetes mellitus (FT1DM) is a new subtype of that was first proposed by the Japanese scholar Imagawa in 2000. In 2 patient cases described this study, gastrointestinal symptoms were reported, and initial blood glucose levels very high. However, glycosylated hemoglobin (HbA1c) not high, islet β-cell function almost completely lost short time, metabolic disorder severe; patients’ β cells demonstrated complete irreversible functional damage, prognosis poor....