A5103253605- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Thyroid and Parathyroid Surgery
- Cancer Risks and Factors
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- MicroRNA in disease regulation
- Heat shock proteins research
- ATP Synthase and ATPases Research
- MRI in cancer diagnosis
- RNA modifications and cancer
- Thyroid Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Renal cell carcinoma treatment
- Traditional Chinese Medicine Analysis
- Ultrasound Imaging and Elastography
- Artificial Intelligence in Games
Qingdao Women and Children's Hospital
2023-2025
Qingdao University
2017-2025
Affiliated Zhongshan Hospital of Dalian University
2010-2024
Southeast Clinical Oncology Research Consortium
2024
Dalian Municipal Central Hospital
2022
Children's Hospital of Chongqing Medical University
2021
Chongqing Medical University
2021
Dalian University
2021
Affiliated Hospital of Qingdao University
2017-2020
Harbin University of Science and Technology
2014
This study aims to investigate the role of targeting lncRNA myocardial infarction-associated transcript (MIAT) in protection against hypoxia/reoxygenation (H/R) injury H9c2 cells vitro and ischemia/reperfusion (I/R) vivo by regulating expression NF-kB p53 upregulated modulator apoptosis (PUMA). H9C2 were infected with lentivirus expressing short-hairpin RNA direct human MIAT gene (Lv-MIAT shRNA) or scrambled control (Lv-NC PUMA siRNA p65 their respectively. Then Lv-shRNA 2 hours hypoxia (H)...
MicroRNA-211 (miR-211) is closely related to apoptosis and plays an important role in ischemia/reperfusion (I/R) injury. Whether miR-211 involved the protective effects renal I/R injury unknown. In this study, we evaluated of human tubular epithelial cells response hypoxia-reoxygenation (H/R) stimulation vitro vivo. The results revealed that was down-regulated TGFβR2 up-regulated kidney (HK-2) subjected H/R. Luciferase reporter assay showed a direct target miR-211. Enforced expression...
Current therapies for HER2-positive breast cancer have limited efficacy in patients with triple-positive (TPBC). We conduct a multi-center single-arm phase 2 trial to test the and safety of an oral neoadjuvant therapy pyrotinib, letrozole dalpiciclib (a CDK4/6 inhibitor) treatment-naïve, stage II-III TPBC Karnofsky score ≥70 (NCT04486911). The primary endpoint is proportion pathological complete response (pCR) axilla. secondary endpoints include residual burden (RCB)-0 or RCB-I, objective...
Accumulating evidence indicates associations between ambient air pollution and Kawasaki disease (KD), but the results remain inconsistent. This systematic review meta-analysis aimed to comprehensively summarize current on effects of pollutants KD. The PubMed, Web Science, Embase, Scopus databases were searched up January 18, 2025 for studies investigating A fixed- or random-effects model was used calculate pooled ORs with 95% CIs an increase in pollutant concentration 10 μg/m3. risk bias...
Abstract Triple‐positive breast cancer (TPBC) poorly responds to current standard neoadjuvant therapy (trastuzumab plus pertuzumab and chemotherapy). Our previous MUKDEN 01 study showed a promising total pathological complete response (tpCR) rate of 30.4% with pyrotinib (pan‐human epidermal growth factor receptor tyrosine kinase inhibitor) dalpiciclib (cyclin‐dependent 4/6 letrozole, but the efficacy remains suboptimal. This pilot (NCT05228951) explored adding trastuzumab this triplet...
BACKGROUND AND OBJECTIVE: Studies in developing animals have demonstrated that when anesthetic agents, such as propofol, are early administered life, it can lead to neuronal cell death and learning disabilities. However, the mechanisms causing these effects remains unknown. A recent report found propofol could significantly upregulat miR-206 expression human ASCs. also induce apoptosis malignant cancers. Therefore, this study, we hypothesized induces neurotoxicity embryonic stem cells...
To determine association of severe anemia and red blood cell (RBC) transfusions with bronchopulmonary dysplasia (BPD) in preterm infants gestational age <32 weeks, a retrospective analysis was conducted on 364 newborns from August 1,2018, until 31,2020. 135 patients were diagnosed BPD the other 229 neonates included non-BPD group. One-to-one propensity score matching (83:83) used to match baseline characteristics confounding factors so as better evaluate effects RBC transfusion. The results...
Background Pyrotinib, a small-molecule tyrosine kinase inhibitor, has been investigated as component of neoadjuvant therapy in phase 2 trials human epidermal growth factor receptor (HER2)-positive breast cancer. This study aimed to evaluate the effectiveness and safety pyrotinib-containing for patients with HER2-positive early or locally advanced cancer real-world setting. Methods Data 97 from 21 centers across China treated were reviewed. Neoadjuvant consisted taxane/carboplatin/trastuzumab...
Ring finger protein 135 (RNF135) is an E3 ubiquitin ligase with RING domains that plays a crucial role in the development of several forms cancer. Neither expression profile RNF135 nor its importance diagnosis pan-cancer have been elucidated as yet. With aid The Cancer Genome Atlas and Gene Expression Omnibus, we fully mapped profiles, prognostic relevance, genetic modification, immune cell infiltration, tumor heterogeneity 33 malignant tumors. was expressed inconsistently various cancers,...
Early prediction of patient responses to neoadjuvant chemotherapy (NACT) is essential for the precision treatment early breast cancer (EBC). Therefore, this study aims noninvasively and predict pathological complete response (pCR). We used dynamic ultrasound (US) imaging changes acquired during NACT, along with clinicopathological features, create a nomogram construct machine learning model. This retrospective included 304 EBC patients recruited from multiple centers. All enrollees had...
The present study aimed to investigate the effect of HSF1 proteins on cell proliferation, apoptosis and invasion breast cancer. Michigan Cancer Foundation-7 (MCF-7) HSF1-knocked down stable line (experimental group) control (control were obtained using a lentivirus assay, effects knockdown tumor formation, ability analyzed, respectively. downstream signals analyzed western blotting. Western blotting results showed that successfully established MCF-7. Compared with group, growth rate MCF-7...
Abstract Background Metaplastic breast cancer (MpBC) is a rare histological subtype of cancer. This study aims to establish competitive risk model for older women with MpBC predict patients’ survival accurately. Methods Data on patients diagnosed from 2010 2019 are the Surveillance, Epidemiology and End Results (SEER) program in United States. All were randomly assigned training set validation set. The proportional sub-distribution was used analyze factors affecting patient death. Based...
This study aims to evaluate whether miR-22 could be used as a potential biomarker screen breast cancer patients from healthy controls. has never been explored.Real time PCR analysis was carried out explore the expression of serum in patients. Chi-square test for counting data. Log rank comparing survival curves. CoX regression model univariate and multivariate prognosis analysis. In addition, we also evaluated role on migration capacity MCF-7 cells using wound healing assay.We found that low...
The present study aimed to investigate the effect of HSF1 proteins on cell proliferation, apoptosis and invasion breast cancer. Michigan Cancer Foundation-7 (MCF-7) HSF1-knocked down stable line (experimental group) control (control were obtained using a lentivirus assay, effects knockdown tumor formation, ability analyzed, respectively. downstream signals analyzed western blotting. Western blotting results showed that successfully established MCF-7. Compared with group, growth rate MCF-7...
e12603 Background: Our previous MUKDEN 01 study showed a promising total pathological complete response (tpCR) rate of 30.4% with neoadjuvant pyrotinib plus dalpiciclib (cyclin dependent kinase 4/6 inhibitor) and letrozole in patients triple-positive breast cancer (TPBC), but the efficacy still needs improvement. This pilot explored safety adding trastuzumab to this regimen TPBC. Methods: Patients received five 28-day cycles (320 mg once daily), (125 daily on days 1-21) (2.5 six 21-day (8...
Tumor microenvironment (TME) status is closely related to breast cancer (BC) prognosis and systemic therapeutic effects. However, date studies have not considered the interactions of immune stromal cells at gene expression level in BC as a whole. Herein, we constructed predictive model, for adjuvant decision-making, by mining TME molecular information patient drug treatment sensitivity.Clinical profiles were extracted from The Cancer Genome Atlas (TCGA), with patients divided into high-...
To the Editor: De-escalating treatment of ductal carcinoma in situ (DCIS) breast has been investigated recent years. A 5-year adjuvant endocrine therapy (AET) regimen is recommended for hormone receptor-positive DCIS. Selective estrogen receptor modulators (such as commonly used tamoxifen and toremifene) aromatase inhibitors (AIs) are currently AET drugs. However, long-term accompanied by severe side effects such menopausal symptoms, endometrial carcinoma, cardiovascular events, venous...