A5101838622- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Cardiac Ischemia and Reperfusion
- FOXO transcription factor regulation
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Traditional Chinese Medicine Analysis
- Microbial infections and disease research
- Cell death mechanisms and regulation
- Calpain Protease Function and Regulation
- Respiratory Support and Mechanisms
- Cancer Research and Treatments
- Carbon and Quantum Dots Applications
- Peptidase Inhibition and Analysis
- Pneumonia and Respiratory Infections
- Adipose Tissue and Metabolism
- Luminescence and Fluorescent Materials
- Nosocomial Infections in ICU
- Melanoma and MAPK Pathways
Jiangsu Cancer Hospital
2024
Nanjing Medical University
2024
Northeastern University
2024
Second Affiliated Hospital of Jilin University
2016-2024
Zhejiang University of Technology
2024
Zunyi Medical University
2024
Nanjing Tech University
2023-2024
Xuzhou Medical College
2016-2024
Nanjing Agricultural University
2020-2024
Chinese PLA General Hospital
2022-2023
Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM PTN-PTPRZ1 paracrine signalling. PTN expression correlates with CD11b+/CD163+ and poor prognosis patients. Co-implantation M2-like (MLCs) promoted GSC-driven tumour growth, silencing in...
A new human hepatocellular carcinoma (HCC) cell line with a highly metastatic potential was established from subcutaneous xenograft of model HCC in nude mice (LCI-D20) by means alternating culture vitro and growth mice. The line, designated MHCC97, has been cultivated for 18 months subcultured more than 90 passages. showed to be origin karyotype analysis. cells were either grown as compact colonies (in clusters) or monolayered sheet about 31 h population-doubling time, exhibited typical...
Abstract Constructing an ultra‐long‐lived red thermally activated delayed fluorescence carbon dots (TADF‐CDs) with time‐dependent phosphorescence colors (TDPC) in both solid and aqueous is still a challenge. Herein, TADF‐CDs, constructed via. modified solid‐state pyrolysis strategy, show the emissions at 595, 670, 725 nm afterglow lifetime longer than most of reported TADF‐materials. In addition, resulting CDs trigger TDPC activity while emission changed from to green state suspension. The...
The proliferation-specific transcription factor Forkhead box M1 (FoxM1) acts as a master regulator of cancer cell growth and survival plays an important role in the development hepatocellular carcinoma. However, molecular mechanisms that regulate FoxM1 expression remain largely unknown. In current study, we demonstrated tumor necrosis (TNF)-αα induced transactivated its promoter activity hepatoma cells. Serial 5″ deletion site-directed mutagenesis revealed induction by TNF-α was dependent...
MicroRNAs (miRNAs) have emerged as critical regulators of neuronal survival during cerebral ischemia/reperfusion injury. Accumulating evidence has shown that miR-211 plays a crucial role in regulating apoptosis and various cell types. However, whether is involved injury remains unknown. In this study, we aimed to explore the biological induced by oxygen-glucose deprivation/reoxygenation (OGD/R) transient (I/R) vitro vivo. We found expression was significantly downregulated PC12 cells...
Abstract Neuroinflammation is closely related with the pathogenesis and progress of neurodegenerative diseases including Alzheimer's disease (AD). Loganin, an iridoid glycoside obtained from traditional Chinese medicine Cornus officinalis , has properties inhibiting inflammation improving memory. The present study was aimed to investigate effects loganin on Aβ‐induced explore underlying mechanisms. BV‐2 microglia cells were stimulated 10 µM Aβ 1‐42 for 24 h induce inflammatory damage....
Non-small cell lung cancer (NSCLC) represents one of the primary causes cancer-related mortality all over world. Following our initial finding upregulated expression E2F transcription factor-1 (E2F1) in NSCLC-related microarray, this study aimed to explore regulatory role E2F1 and underlying mechanism NSCLC development. viability, migration, invasion were evaluated utilizing Cell Counting Kit 8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU), wound-healing, Transwell assays. Loss- gain-function...
Insulin resistance plays a major role in the development and progression of cardiac hypertrophy heart failure. Heart failure turn promotes insulin increases risk for diabetes. The vicious cycle determines significant mortality patients with However, underlying mechanisms are not fully elucidated. Here we show that circulating levels adipose expression retinol-binding protein 4 (RBP4), an adipokine contributes to systemic resistance, were elevated induced by transverse aortic constriction...
Abstract Background/objective People living with HIV (PLWH) are prone to mental health problems and evidence indicates that HIV-related stigma can negatively impact health-related quality of life. This study explored potential mechanisms between life, specifically whether anxiety or depression mediates, social support moderates, the relationship. Method A total 1197 Chinese PLWH participated in study. The Berger Stigma Scale, Hospital Anxiety Depression Scale (HADS), 12-item Brief Health...
To investigate the cytotoxicity of silk fibroin/gelatin (SF/G) composite scaffolds in vitro as well their biocompatibility and degradation vivo.The proliferation relative growth rate human hepatic QZG cells grown on different blends two-dimensional (2-D) SF/G were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Flow cytometry was used to evaluate apoptotic 2-D scaffolds. The effect protein materials cell observed by scanning electron microscopy....
Neurodegenerative diseases present progressive neurological disorder induced by cell death or apoptosis. Catalpol, an iridoid glucoside isolated from the root of Rehmannia glutinosa Libosch, is in a wide range plant families. Although catalpol effective anti-apoptotic agent LPS-induced neurodegeneration, underlying mechanism has not been established. Here we have identified some mechanisms involved prevention apoptosis LPS experimental model neurodegeneration vitro.Apoptosis was adding (80...
Abstract Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, numerous advantages the rodent that make it superior irreplaceable animal model for studying stroke brain. In present study, after mapping preferred hand representation two healthy male monkeys with intracortical micro-stimulation, ET-1 was microinjected into contralateral motor cortex (M1) its hand. had trained three manual dexterity...
MicroRNA-211 (miR-211) is closely related to apoptosis and plays an important role in ischemia/reperfusion (I/R) injury. Whether miR-211 involved the protective effects renal I/R injury unknown. In this study, we evaluated of human tubular epithelial cells response hypoxia-reoxygenation (H/R) stimulation vitro vivo. The results revealed that was down-regulated TGFβR2 up-regulated kidney (HK-2) subjected H/R. Luciferase reporter assay showed a direct target miR-211. Enforced expression...
To investigate the application value of metagenomic next-generation sequencing (mNGS) in children with hematological diseases presenting Febrile Neutropenia (FN).We retrospectively analyzed clinical data 49 FN, and compared results mNGS those traditional pathogen detection (TPD) prognoses positive group negative group.A total 77 pathogenic strains were identified, which 70 detected by mNGS, 19 TPD, Aspergillus G- bacterias predominant FN who developed bloodstream infections. 42 cases...
Time‐dependent phosphorescence color (TDPC) materials are highly attractive for realizing multitiered dynamic information encryption and anti‐counterfeiting. It’s extremely challenging to modulate puzzle of multiple luminescence species understand the intrinsic mechanism. Herein, we demonstrate a novel synthesize‐friendly strategy develop high contrast TDPC carbonized polymer dots (CPDs) with adjustable lifetime quantum yields. The ionic bonding is introduced in self‐protected CPDs...
MicroRNAs (miRNAs) are thought to have an important role in tumor metastasis by regulating diverse cellular pathways. Here, we describe the function and regulation network of miR-206 gastric cancer (GC) metastasis. MiR-206 expression was downregulated GC cells especially high metastatic potential also significantly decreased lesions compared with their corresponding primary samples. Both gain- loss-of-function studies confirmed that suppressed cell invasion both vitro vivo. Mechanistically,...
PURPOSE: To investigate the incidence and clinical results of corneal complications after small incision lenticule extraction (SMILE). METHODS: A retrospective cohort study including 3,223 patients (6,373 eyes) who were treated for myopia or myopic astigmatism was conducted. Postoperative recorded. follow-up visits scheduled on days 1 7 months 1, 3, 6, 12. RESULTS: Of 6,373 cases, 432 eyes (6.8%) developed at least one complication postoperatively. These included punctate epithelial erosions...
Abstract BACKGROUND Heat stress seriously affects animal health and induces enormous financial losses in poultry production. Exploring the appropriate means for ameliorating unfavorable effects caused by heat is essential. We investigated whether taurine supplementation could attenuate breast muscle loss chronic heat‐stressed broilers, as well its mechanism. designed three groups: a normal control group (22 °C), (32 °C) treatment °C, basal diet + 5 g·kg −1 taurine). RESULTS found that...