A5100601146- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Bioactive Compounds
- Biological and pharmacological studies of plants
- Neurological Disorders and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Kidney Stones and Urolithiasis Treatments
- Cancer-related molecular mechanisms research
- Marine Sponges and Natural Products
- Ferroptosis and cancer prognosis
- Phytochemical Studies and Bioactivities
- Nitric Oxide and Endothelin Effects
- Phosphodiesterase function and regulation
- Biochemical effects in animals
- Urinary Tract Infections Management
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Natural product bioactivities and synthesis
- Prostate Cancer Treatment and Research
- Cholinesterase and Neurodegenerative Diseases
- Bladder and Urothelial Cancer Treatments
- Catalytic Processes in Materials Science
- Inflammasome and immune disorders
- Pediatric Urology and Nephrology Studies
Kunming Medical University
2015-2025
Zhongshan Ophthalmic Center, Sun Yat-sen University
2024-2025
Zhongshan Hospital
2024-2025
Sun Yat-sen University
2024
Beijing Jishuitan Hospital
2024
Peking University
2024
Shanghai Research Institute of Chemical Industry
2006-2023
First Affiliated Hospital of Zhengzhou University
2023
Anhui Medical University
2023
Sinopec (China)
2023
Vascular dementia (VD) is the second most common syndrome worldwide, and effective treatments are lacking. Gastrodia elata Blume (GEB) has been used in traditional Chinese herbal medicine for centuries to treat cognitive impairment, ischemic stroke, epilepsy, dizziness. Gastrodin (p-hydroxymethylphenyl-b-D-glucopyranoside, Gas) Gastrodigenin (p-hydroxybenzyl alcohol, HBA) main bioactive components of GEB. This study explored effects Gas HBA on dysfunction VD their possible molecular...
<title>Abstract</title> <bold>Objective:</bold> To elucidate the association between dietary iron intake and diabetic retinopathy (DR) in type 2 diabetes (T2D) patients. <bold>Methods:</bold> Participants from National Health Nutrition Examination Survey (NHANES) 2005-2008 aged over 40 years with T2D were included. Dietary was estimated standardised questionnaires. The presence of DR vision-threatening (VTDR) determined through retinal imaging. We used logistic regression to assess...
Vascular dementia (VaD) is the second most common type of and has become a major public health challenge as global population ages. VaD caused by cerebrovascular disease, patients with have been reported to also Alzheimer’s pathologies, which formation neurofibrillary tangles amyloid plaques that are mainly composed hyperphosphorylated Tau β (Aβ) respectively. However, mechanisms not completely understood, very few drugs available treat this condition. Gastrodin (Gas) main bioactive...
The pathophysiology of cardiac hypertrophy is complex and multifactorial. Both the store-operated Ca 2+ entry (SOCE) excessive autophagy are major causative factors for pathological hypertrophy. However, it unclear whether these two interdependent. In this study, we examined functional role SOCE Orai1 in angiotensin II (Ang II)-induced using vitro neonatal rat cardiomyocytes (NRCMs) vivo mouse model, respectively. We show that YM-58483 or SKF-96365 mediated pharmacological inhibition SOCE,...
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with high mortality rates. Viral and bacterial coinfection the primary cause AECOPD. How these microbes influences host inflammatory response gut microbiota composition not entirely understood.We developed a mouse model AECOPD by cigarette smoke exposure sequential infection influenza H1N1 virus non-typeable Haemophilus influenzae (NTHi). titer was determined using MDCK cells chocolate agar plates,...
Pathological cardiac hypertrophy is commonly associated with an upregulation of fetal genes, fibrosis, dysfunction, and heart failure. Previous studies have demonstrated that gastrodin (GAS) exerts cardioprotective action in the treatment hypertrophy. However, mechanism by which GAS protects against yet to be elucidated. A mouse model myocardial was established using angiotensin II (Ang II) induction. (5 or 50 mg/kg/d) orally administered every day starting 7 days prior Ang infusion combined...
The principal active component of isoforskolin (ISOF) is from the plant Coleus forskohlii , native to China, which has attracted much attention for its biological effects. We hypothesize that ISOF and forskolin (FSK) pretreatment attenuates inflammation induced by lipopolysaccharide (LPS) related toll‐like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear kappa B (NF‐κB) signaling. Mononuclear leukocytes (MLs) healthy donors' blood samples were separated using density...
Sepsis is a life-threatening infectious disease in which an immune inflammatory response triggered. The potential effect of ferroptosis-related genes (FRGs) inflammation sepsis remained unclear. We focused on identifying and validating core FRGs their association with infiltration blood from currently all patients sepsis. All current raw data septic were obtained Gene Expression Omnibus. After removing the batch merging into complete dataset obtaining Diferentially expressed (DEGs). Common...
Scutellarin (SCU), a flavonoid glycoside compound, has been successfully used in clinic for treatment of ischemic diseases China. In this report, we checked the effects SCU on endothelium dysfunction (ED) coronary artery (CA) against myocardial ischemia reperfusion (MIR) injury vivo. The involvement PKG-Iα was further studied using cultured endothelial cells subjected to hypoxia reoxygenation (HR) vitro. rat MIR model, (45 and 90 mg/kg, iv) significantly reduced size restored...
Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These are associated with oxidative stress triggered by intermittent hypoxia OSA. Sestrin2 crucial factor involved stress. The goal of this study was to investigate if relationship exists between OSA Sestrin2. We prospectively enrolled 71 subjects, 16 patients them severe completed 4 weeks nasal continuous positive airway pressure (nCPAP)...
Asthma is a chronic disease that seriously harms the health of patients. Oxidative stress involved in asthma. As an oxidative stress-inducible protein, sestrin2 elevated stress-related diseases. We aimed to explore whether was asthma.Seventy-six subjects (44 asthma group, 32 control group) were recruited this study. Plasma levels, peak expiratory flow (PEF), forced volume 1 s (FEV1) % predicted, vital capacity (FVC) predicted and FEV1/FVC ratio measured controls asthmatics both during...
Chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide, is widely considered to be related cigarette smoke (CS), viral infections trigger acute exacerbation COPD (AECOPD). Isoforskolin (ISOF) bioactive component from the plant Coleus forskohlii , native Yunnan in China. It has been demonstrated that ISOF anti-inflammatory effect on lung injury animal models. In present study, we investigated efficacy mechanism for prevention treatment AECOPD. Mice...
Cyclic adenosine monophosphate (cAMP) levels are directly activated by adenylate cyclase (AC) and play an anti-inflammatory role in chronic obstructive pulmonary disease (COPD). Previously, we have shown that isoforskolin (ISOF) can effectively activate AC1 AC2 vitro, improve ventilation reduce the inflammatory response COPD model rats, supporting ISOF may be a potential drug for prevention treatment of COPD, but mechanism has not been explored detail.The pharmacological mechanisms against...
Background: Sepsis is initiated by the dysfunctional response of host immune system to infection. Septic shock and acute lung injury (ALI) are main etiology death caused sepsis. Glucocorticoids, which commonly used in clinic antagonize inflammatory sepsis, may cause serious side effects. Isoforskolin (ISOF) from plant Coleus forskohlii stimulates adenylyl cyclase, increases cAMP level inhibits response. The aim this study was investigate synergistic effect ISOF with dexamethasone (DEX)...
Scutellarin (SCU) is one of the main components traditional Chinese medicine plant Erigeron breviscapus (Vant.) Hand.-Mazz. In this paper, we studied protective effects SCU on human cardiac microvascular endothelial cells (HCMECs) against hypoxia-reoxygenation (HR) injury and its possible target-related proteins. Results MTT assay showed that pretreatment at doses 1, 5, 10 μ M for 2 h could significantly inhibit decrease in cell viability HCMECs induced by HR injury. Subcellular fractions...