A5036590989- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- CRISPR and Genetic Engineering
- Congenital Anomalies and Fetal Surgery
- interferon and immune responses
- Immune Cell Function and Interaction
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Pediatric health and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
Kunming University of Science and Technology
2018-2023
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with high mortality rates. Viral and bacterial coinfection the primary cause AECOPD. How these microbes influences host inflammatory response gut microbiota composition not entirely understood.We developed a mouse model AECOPD by cigarette smoke exposure sequential infection influenza H1N1 virus non-typeable Haemophilus influenzae (NTHi). titer was determined using MDCK cells chocolate agar plates,...
As SARS-CoV-2 variants continue to evolve, identifying with adaptive diagnostic tool is critical containing the ongoing COVID-19 pandemic. Herein, we establish a highly sensitive and portable on-site detection method for HV69-70del which exist in Alpha Omicron using PCR-based CRISPR/Cas13a system (PCR-CRISPR). The specific crRNA (CRISPR RNA) targeting screened fluorescence-based CRISPR assay, sensitivity specificity of this are evaluated diluted nucleic acids other pathogens. results show...
Abstract Background Whether pediatric rotavirus infection is associated with extraintestinal complications remains unknown. Methods We conducted a case-control study to investigate the incidences and risks of rotavirus-associated in hospitalized newborns, infants, children younger than 5 years. Results A total 1325 young inpatients (754 male 539 newborns) 1840 controls without (1035 836 were included. The neurological disease higher among individuals compared controls: 7.24% (39/539) versus...
As a universal pathogen leading to neonatal defects and transplant failure, Human cytomegalovirus (HCMV) has strict species specificity that the inability using this virus in animals hampered its pathogenesis study. However, mechanism of cross-species barrier remains elusive no non-human cell model been established fill knowledge gap. We observed primary dermis fibroblasts (TSDF) isolated from Chinese tree shrew (Tupaia belangeri chinensis), small laboratory animal with close affinity...
Background: Severe coronavirus disease 2019 (COVID-19) has been a critical threat to public health worldwide. Integrating the polygenic information from Genome-wide association study (GWAS) data with single-cell sequencing (scRNA-seq) could provide further insights into factors associated infection progression. However, previous integration analysis largely focused on predefined cell-type annotations but overlooked heterogeneity of individual cells within cell types provided by...