A5054397881- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Viral Infections and Immunology Research
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- RNA modifications and cancer
- Congenital Anomalies and Fetal Surgery
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease and Transplantation
- Amoebic Infections and Treatments
- COVID-19 diagnosis using AI
- Vibrio bacteria research studies
- Plant Virus Research Studies
- Lipid metabolism and biosynthesis
- Viral Infections and Vectors
- HIV/AIDS Research and Interventions
- Cytokine Signaling Pathways and Interactions
- HIV/AIDS oral health manifestations
- Viral-associated cancers and disorders
Kunming University of Science and Technology
2016-2024
Erasmus MC
2018-2022
Minzu University of China
2018
Noroviruses are the main causative agents of acute viral gastroenteritis, but host factors that restrict their replication remain poorly identified. Guanylate-binding proteins (GBPs) interferon (IFN)-inducible GTPases exert broad antiviral activity and important mediators defenses against infections. Here, we show both IFN-γ stimulation murine norovirus (MNV) infection induce GBP2 expression in macrophages. Results from loss- gain-of-function assays indicated is for IFN-γ-dependent anti-MNV...
Human Pegivirus-1 (HPgV-1) may have a beneficial impact on disease progression in human immunodeficiency virus-1 (HIV-1) infection. However, analysis of the genotypic diversity HPgV-1 and its relevance to HIV-1 remains limited. A total 1062 HIV-1-infected individuals were recruited all sixteen prefectures Yunnan province, China. The reverse transcription nested polymerase chain reaction (RT-nPCR), phylogenetic analyses, clinical data analyses used detect infection, determine genotype,...
Although cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling has been well recognized in defending DNA viruses, the role cGAS-STING regulating infection RNA viruses remains largely elusive. Noroviruses, as single-stranded are main causative agents acute viral gastroenteritis worldwide. This study comprehensively investigated response to murine norovirus (MNV) infection. We found that STING agonists potently inhibited MNV replication mouse macrophages partially...
We report a novel HIV circulating recombinant form (CRF78_cpx) composed mainly of CRF01_AE with inserts from subtypes B and C identified three epidemiologically unlinked individuals in Yunnan province, China. Two the subjects are heterosexual men one is male intravenous drug user. Sequencing analyzing near-full-length genome these isolates (YNTC88, YNTC19, YNTC35) revealed identical recombination breakpoints all viruses, but considerable genetic diversity between them, across genomes,...
Summary Hepatitis delta virus ( HDV ), as a defective sub‐virus that co‐infects with hepatitis B virus, imposes an emerging global health burden. However, genetic characteristics and molecular classification of remain under investigated. In this study, we have systematically retrieved analysed large set full‐length genome sequences identified novel recombinants. Based on phylogenetic analyses, established updated system for when recombinants were excluded. Furthermore, mapped the...
In recent years, multiple circulating recombinant forms (CRFs) and unique of human immunodeficiency virus type 1 (HIV-1) have been described in Yunnan, China. Here, we identified a novel HIV-1 CRF (CRF86_BC) isolated from three heterosexuals with no obvious epidemiologic linkage western Yunnan (Baoshan prefecture) CRF86_BC had subtype C backbone four B fragments inserted into the pol, vpr, vpu, env, nef gene regions, respectively. Furthermore, subregion tree analysis revealed that originated...
Currently, complex HIV-1 recombinations among the B', C, and CRF01_AE genotypes have frequently arisen in Yunnan, China. A novel circulating recombinant form (CRF) consisting of (CRF96_cpx) was recently characterized from three epidemiologically unlinked individuals. Two strains them were isolated injecting drug users this study, remaining one strain (JL. RL01) obtained a previous report Jilin province. Phylogenetic analysis based on near full-length genome revealed that CRF96_cpx formed...
Hepatitis E virus (HEV) infection in immunocompromised patients often results distinct outcome, compared to the general population. This study aimed investigate prevalence, potential risk factors, and clinical features of HEV among HIV treated with antiretroviral therapy (ART) Yunnan province, China. A total 770 HIV-infected between May 2015 February 2016 were enrolled Yunnan, All received ART. plasma samples tested for anti-HEV IgG, IgM antibodies using ELISA kits, RNA by real-time qRT-PCR....
Abstract We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic extrahepatic cells. Long-term treatment showed no clear evidence the development drug resistance. Gene silencing importin-α1, cellular target ivermectin key member host nuclear transport complex, inhibited viral replication largely abolished anti-HEV effect ivermectin.
The landscape of tRNA-viral codons regulates viral adaption at the translational level, presumably through adapting to host codon usage or modulating tRNAome. We found that major zoonotic genotype hepatitis E virus (HEV) has not adapted usage, prompting exploration effects HEV infection on However, tRNAome quantification is largely impeded by extremely short sequences tRNAs and redundancy tRNA genes. Here, we present a length-extension stepwise simplified qPCR method utilizes universal...
The nomenclature of duck viral hepatitis (DVH) was historically not a problem. However, 14 hepatotropic viruses among 10 different genera are associated with the same disease name, DVH. Therefore, name increasingly lacks clarity and may no longer fit scientific description disease. Because one should be attributed to viruses, this almost certainly causes misunderstanding regarding disease-virus relationship. Herein, we revisited problem proposed an update DVH classification. This...
Abstract Human herpesviruses (HHVs) have a particularly high prevalence in certain high‐risk populations and cause increased morbidity mortality patients with acquired immunodeficiency syndrome (AIDS). Screening treating subclinical HHV infections reduce human virus (HIV) infection incidence, disease progression, transmission. However, there are few studies on HHVs, HIV coinfection rates, their related risk factors. We aimed to clarify the of all eight HHVs peripheral blood samples collected...
Noroviruses are the main causative agents for acute viral gastroenteritis worldwide. RIG-I-like receptors (RLRs) triggered interferon (IFN) activation is essential host defense against infections. In turn, viruses have developed sophisticated strategies to counteract antiviral response. This study aims investigate how murine norovirus (MNV) replicase interacts with RLRs-mediated IFN Counterintuitively, we found that MNV NS7 enhances of poly (I:C)-induced response and transcription downstream...
Hepatitis E virus (HEV) infection in immunocompromised patients, pregnant women and children requires treatment; however, no approved medication is currently available. The macrolide antibiotic azithromycin has been identified as a potent HEV inhibitor. Azithromycin inhibits replication viral protein expression multiple cell culture models with genotype 1 3 strains. This largely independent of its induction an interferon-like response. Because it safe cheap, repurposing for treating...
Abstract Background Whether pediatric rotavirus infection is associated with extraintestinal complications remains unknown. Methods We conducted a case-control study to investigate the incidences and risks of rotavirus-associated in hospitalized newborns, infants, children younger than 5 years. Results A total 1325 young inpatients (754 male 539 newborns) 1840 controls without (1035 836 were included. The neurological disease higher among individuals compared controls: 7.24% (39/539) versus...
Abstract Noroviruses are the main causative agents of acute viral gastroenteritis worldwide. However, no vaccine or specific antiviral treatment is available, imposing a heavy global health burden. The nucleoside analogue 2’-fluoro-2’-deoxycytidine (2’-FdC) has been reported to have broad activity. Here, we report that 2’-FdC significantly inhibits murine norovirus replication in macrophages. This effect was partially reversed by exogenous supplementation cytidine triphosphate. combination...