A5035312767- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Toxoplasma gondii Research Studies
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Viral Infections and Vectors
- Pharmaceutical and Antibiotic Environmental Impacts
- Viral-associated cancers and disorders
- Hepatitis Viruses Studies and Epidemiology
- Toxin Mechanisms and Immunotoxins
- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Iron Metabolism and Disorders
Sichuan Agricultural University
2016-2025
Sichuan Center for Disease Control and Prevention
2023-2025
Ministry of Education of the People's Republic of China
2023-2025
Science and Technology Department of Sichuan Province
2024
Erasmus MC
2018-2022
China Rural Technology Development Center
2016
Goose astrovirus (GAstV) is a newly identified viral pathogen threatening waterfowl, exhibiting high prevalence across various regions in China. Notably, the Guanghan District of Deyang City, situated Sichuan Province, has faced outbreak GAstV, resulting significant mortality among goslings due to induction gout-like symptoms. In our research, we successfully isolated GAstV strain known as SCG3. This exhibits efficient replication capabilities, proving virulent and goose embryos. Our study...
There are rising concerns about microbes harboring antibiotic resistance genes (ARGs) and virulence-associated (VAGs) in humans food-producing animals. Moreover, ARGs considered as emerging environmental pollutants, posing probable life-threatening complications Commensal Escherichia coli (E. coli) strain can carry a large number of VAGs, which may become opportunistic pathogen. The objective this study was to determine the prevalence possible association VAGs E. isolates from clinically...
Abstract In herpesvirus, the terminase subunit pUL15 is involved in cleavage of viral genome concatemers nucleus. Previous studies have shown that herpes simplex virus 1 (HSV-1) can enter nucleus without other proteins and help subunits However, this study revealed duck plague (DPV) cannot localize independently to only be localized presence pUL28 pUL33. data suggested a potential nuclear localization signal (NLS) DPV pUL15, which important for subunits. Subsequently, several single-point...
Abstract Several bacterial pathogens employ haemophores to scavenge haem from host haemoprotein obtain an iron source. However, no homologues of well‐characterized are found in Riemerella anatipestifer , a bacterium belonging the order Flavobacteriales that encodes uptake systems. Herein, unique haemophore RhuH is characterized this bacterium. R. used grow when duck hemoglobin serves as sole resource. secreted component outer membrane vesicles. Recombinant exhibited high binding affinity for...
Avian reovirus (ARV), a double-stranded RNA virus, frequently induces immunosuppression in poultry, leading to symptoms such as irregular bleeding and spleen necrosis infected ducks. Since 2017, the morbidity mortality rates associated with ARV infection poultry have been on rise, progressively emerging significant viral disease impacting duck farming industry China. In our study, we collected embryo fibroblasts 18 h post-infection conducted transcriptome sequencing analysis. The analysis...
ABSTRACT Zinc (Zn 2+ ) is essential for all bacteria, but excessive Zn levels are toxic. Bacteria maintain zinc homeostasis through regulators, such as Zur, AdcR, and ZntR. Riemerella anatipestifer a significant Flavobacteriales pathogen causing acute serositis in ducks other birds. In this study, we identified homolog of ZntR, regulator homeostasis, demonstrated its contribution to the pathogenicity R. . Deletion zntR makes bacteria hypersensitive excess not metals like manganese (Mn ),...
Duck hepatitis A virus type 1 (DHAV-1) is an acute, highly lethal infectious agent that infects ducklings and causes up to 95% mortality in week of age, posing a significant economic threat the duck farming industry. Previous studies have found proteolytic enzyme 3 C encoded by DHAV-1 can inhibit IRF7 protein from blocking upstream signaling pathway I interferon promote viral replication. However, there are still few on mechanism immune evasion. Here, we demonstrate 3CD interact with reduce...
DPV is a highly lethal alphaherpesvirus that causes duck plague in birds of the order Anseriformes. The virus has caused huge economic losses to poultry industry due high morbidity and mortality cost vaccination.
Duck circovirus genotype 2 (DuCV2) belongs to the genus Circovirus, family Circoviridae. It can generally cause lymphocyte atrophy and necrosis in ducks, which leads immunosuppression. The function of DuCV2 open reading frame 3 (ORF3) protein viral pathogenesis host cells remains unclear. Therefore, a series studies based on ORF3 isolate DuCV GH01 strain (belonging DuCV2) were carried out duck embryo fibroblasts (DEFs) this study. results showed that could induce nuclear shrinkage...
In bacteria, manganese homeostasis is controlled by import, regulation, and efflux. Here, we identified 2 Mn exporters, MetA MetB (manganese efflux transporters A B), in Riemerella anatipestifer CH-1, encoding a putative cation diffusion facilitator (CDF) protein resistance-nodulation-division (RND) pump, respectively. Compared with the wild type (WT), ΔmetA, ΔmetB, ΔmetAΔmetB exhibited sensitivity to manganese, since they accumulated more intracellular Mn2+ than WT under excess conditions,...
Abstract The maintenance of viral protein homeostasis depends on the interaction between host cell proteins and proteins. As a molecular chaperone, heat shock 70 (HSP70) has been shown to play an important role in infection. Our results showed that HSP70 can affect translation, replication, assembly, release during life cycle duck hepatitis A virus type 1 (DHAV-1). We demonstrated regulate translation by interacting with DHAV-1 internal ribosome entry site (IRES). In addition, interacts...