A5005670932- Microbial infections and disease research
- Plant Virus Research Studies
- Genetic Mapping and Diversity in Plants and Animals
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Aquaculture disease management and microbiota
- Bacterial biofilms and quorum sensing
- Genomics and Phylogenetic Studies
- Vibrio bacteria research studies
- Infections and bacterial resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Zoonotic diseases and public health
- Geoscience and Mining Technology
- Escherichia coli research studies
- Landslides and related hazards
- Salmonella and Campylobacter epidemiology
- Energy Load and Power Forecasting
- Monoclonal and Polyclonal Antibodies Research
- Educational Technology and Assessment
- Insect and Pesticide Research
- Soil, Finite Element Methods
- Biosimilars and Bioanalytical Methods
- Remote Sensing and Land Use
- Model Reduction and Neural Networks
Guizhou University
2025
Sichuan Agricultural University
2019-2024
Ministry of Education of the People's Republic of China
2023-2024
Sichuan Center for Disease Control and Prevention
2023-2024
Science and Technology Department of Sichuan Province
2024
Sichuan University
2022
Jilin University
2011-2020
Solving partial differential equations of complex physical systems is a computationally expensive task, especially in Computational Fluid Dynamics(CFD). This drives the application deep learning methods solving systems. There exist few models that are very successful predicting flow fields models, yet most these still exhibit large errors compared to simulation. Here we introduce AMGNET, multi-scale graph neural network model based on Encoder-Process-Decoder structure for field prediction....
There are rising concerns about microbes harboring antibiotic resistance genes (ARGs) and virulence-associated (VAGs) in humans food-producing animals. Moreover, ARGs considered as emerging environmental pollutants, posing probable life-threatening complications Commensal Escherichia coli (E. coli) strain can carry a large number of VAGs, which may become opportunistic pathogen. The objective this study was to determine the prevalence possible association VAGs E. isolates from clinically...
Bacterial antimicrobial resistance (AMR) continues to develop, with the horizontal transfer of antibiotic genes (ARGs) through plasmids playing a major role. Recently, R. anatipestifer has become increasingly severe, jeopardizing development poultry industry. In this study, we used PromethION determine whole genome sequence RCAD0416, multidrug-resistant isolate from China. We detected plasmid in isolate. named pRCAD0416RA-1; was 37356 bp size 36 putative open reading frames and included...
ABSTRACT Riemerella anatipestifer ( R. ) is an important pathogen that causes severe systemic infections in domestic ducks, resulting substantial economic losses for China’s waterfowl industry. Controlling with antibiotics extremely challenging due to its multidrug resistance. Notably, large-scale studies on antimicrobial resistance (AMR) and the corresponding genetic determinants remain scarce. To solve this dilemma, more than 400 nonredundant isolates collected from 22 provinces China...
Abstract Background The disease caused by Riemerella anatipestifer ( R. , RA) results in large economic losses to the global duck industry every year. Serovar-related genomic variation, such as O-antigen and capsular polysaccharide (CPS) gene clusters, has been widely used for serotyping many gram-negative bacteria. RA classified into at least 21 serovars based on slide agglutination, but molecular basis of is unknown. In this study, we performed a pan-genome-wide association study...
Abstract Objectives To elucidate the role of a novel carbapenem-hydrolysing class D β-lactamase (RAD-1) from Riemerella anatipestifer. Methods We applied WGS and bioinformatic analysis to screen putative genes in R. anatipestifer SCVM0004. A gene was cloned into pET24a transferred Escherichia coli BL21 (DE3) for antibiotic susceptibility determination protein purification. Meanwhile, purified native used determine enzymatic activities. Results β-lactamase, RAD-1, identified genome It...
ABSTRACT Riemerella anatipestifer ( R. ) is a Gram-negative pathogen that causes significant economic losses to the farming industry. The polysaccharides determine serotype are well understood in other bacteria; they have not yet been fully characterized . In this study, we unexpectedly discovered strain, RCAD0392, capable of cross-agglutination. Whole genome sequencing revealed base mutations disrupting gene on its capsular polysaccharide synthesis cluster. By constructing homologous...
Iron is an essential element for the replication of most bacteria, including Riemerella anatipestifer, a Gram-negative bacterial pathogen ducks and other birds. R. anatipestifer utilizes hemoglobin-derived hemin as iron source; however, mechanism by which this bacterium acquires from hemoglobin largely unknown. Here, rhuA disruption was shown to impair utilization duck in CH-1. Moreover, putative lipoprotein RhuA identified surface-exposed, outer membrane hemin-binding protein, but it could...
Salmonella enterica is a widespread foodborne pathogen with concerning antimicrobial resistance (AMR). Waterfowl are major source of transmission, but there few systematic studies on prevalence in waterfowl species. In this study, 126 isolates (65 collected 2018–2020 and 61 2002–2005) were obtained from samples Sichuan, China. Their serotypes, pulsed-field gel electrophoresis (PFGE) types, phenotypic genotypic AMR profiles systematically examined. The distributed 7 including serovars...
Pasteurella multocida (P. multocida) is a bacterial pathogen responsible for range of infections in humans and various animal hosts, causing significant economic losses farming. Integrative conjugative elements (ICEs) are important horizontal gene transfer elements, potentially enabling host bacteria to enhance adaptability by acquiring multiple functional genes. However, the understanding ICEs P. their impact on transmission this remains limited. In study, 42 poultry-sourced genomes...
Pasteurella multocida (P. multocida) is a widespread opportunistic pathogen that infects human and various animals. Genomic Islands (GIs) are one of the most important mobile components quickly help bacteria acquire large fragments foreign genes. However, effects GIs on P. unknown in evolution bacterial populations.
A novel chromosome-encoded metallo-β-lactamase (MBL) EBR variant, namely, EBR-5, was identified in a multidrug-resistant Empedobacter stercoris strain SCVM0123 that isolated from chicken anal swab samples. EBR-5 shared 82.13% amino acid identity with the previously known EBR-1. The expression of Escherichia coli reduced susceptibility to expanded-spectrum cephalosporins and carbapenems. Compared
We report for the first time occurrence of integrative conjugative elements (ICEs) in Riemerella anatipestifer (R.anatipestifer) isolated from diseased ducks China. For this purpose, a total 48 genome sequences were investigated, which comprised 30 publicly available R. sequences, and 18 clinical isolates genomes sequences. Two ICEs, named ICERanRCAD0133-1 ICERanRCAD0179-1 following classic nomenclature system, identified through use bioinformatics tools. Comparative analysis revealed that...
Abstract During the COVID-19 pandemic, precisely tracing route of SARS-CoV-2 transmission in human population remains challenging. Because this RNA virus can mutate massively without a specifically maker. Herein, using geographic stratified genome-wide association study (GWAS) 2599 full-genome sequences, we identified that two SNPs (i.e., 1059.C>T and 25563.G>T) linkage disequilibrium were presented approximately half North America (p = 2.44 x 10 −212 p 2.98 −261 ), resulting missense...
Abstract Since Omicron variant of SARS-CoV-2 was first detected in South Africa (SA), it has now dominated United Kingdom (UK) Europe and State (USA) North America. A prominent feature this is the gathering spike protein mutations, particularly at receptor binding domain (RBD). These RBD mutations essentially contribute to antibody resistance current immune approaches. During global spillover, combinations may exist synergistically fact. Using three geographic-stratified genome wide...