A5100682174- Thyroid Disorders and Treatments
- Respiratory viral infections research
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Bone Metabolism and Diseases
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Bone health and treatments
- Vitamin D Research Studies
- Viral gastroenteritis research and epidemiology
- Diet and metabolism studies
- Estrogen and related hormone effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hormonal Regulation and Hypertension
- Neonatal Health and Biochemistry
- Receptor Mechanisms and Signaling
- Herpesvirus Infections and Treatments
- Drug Transport and Resistance Mechanisms
- Magnesium in Health and Disease
- Ion channel regulation and function
- Infectious Encephalopathies and Encephalitis
- SARS-CoV-2 and COVID-19 Research
- Adrenal Hormones and Disorders
- Alcohol Consumption and Health Effects
- Diabetes Management and Research
Shandong Provincial Hospital
2012-2024
Shandong University
2012-2024
Shandong First Medical University
2024
Children's Hospital of Fudan University
2017-2023
Fudan University
2013-2023
Southwest Medical University
2020
Shandong Academy of Chinese Medicine
2012-2019
Xuan Wu Hospital of the Capital Medical University
1996
Capital University
1996
Dyslipidemia in thyroid dysfunction has always been attributed to changes hormone (TH) levels. We hypothesized that TSH plays an important role lipid metabolism independent of TH. conducted a cross-sectional study investigate the relationship between serum levels and profiles after controlling for free T3, T4, total T4 nonthyroid factors relevant euthyroid Chinese subjects. General linear analysis was performed determine whether impact on is TH Moreover, path analysis, evolutionary...
Objective The objectives of this study were to observe the changes in follicle-stimulating hormone (FSH) and bone mineral density (BMD) postmenopausal women, research relationship between FSH osteoporosis, effects on osteoclast differentiation RAW264.7 cells. Methods We analyzed 248 women with normal metabolism. A radioimmunoassay (RIA) was used detect serum FSH, luteinizing (LH), estradiol (E2). Dual-energy X-ray absorptiometry measure forearm BMD. Then, we age-related LH E2. Additionally,...
Dyslipidemia is an important global health problem, particularly in the elderly population. Traditionally, high prevalence of dyslipidemia people considered a "natural condition." Notably, subclinical hypothyroidism (SCH) one most risk factors for dyslipidemia. Few studies have assessed whether SCH plays role increase age-related This study aimed to explore association between and lipid profiles different age groups.This was large-scale, population-based, case-control study. The population...
Serum lipid profiles may be influenced by thyroid function, but the detailed mechanism remains unclear. Increasing evidence suggests that thyrotropin (TSH) exert extra-thyroidal effects. The goal of this study was to evaluate relationship between serum TSH levels and in euthyroid non-smokers with newly diagnosed asymptomatic coronary heart disease (CHD).This a retrospective 406 (187 males 219 females) CHD from 2004 2010 Jinan, China. Lipid parameters TSH, FT3, FT4 were determined. Multiple...
Our previous study reported that thyroid-stimulating hormone (TSH) promotes cholesterol synthesis via the cyclic adenosine monophosphate/protein kinase A/cAMP regulatory element-binding protein (cAMP/PKA/CREB) pathway after binding to TSH receptors (TSHR) in liver. The hepatic cAMP/PKA/CREB also plays an important role maintaining fasting glucose homeostasis. These findings implied a possible for metabolism. In this study, we used receptor knockout mice (Tshr-ko mice) clarify effect of Tshr...
With an increased incidence of obesity in China, this study sought to investigate the correlation between serum 25-hydroxyvitamin D levels and adiposity phenotypes Chinese adults from urban settings.A total 1277 subjects aged 20-82 years old were recruited into cross-sectional study. Anthropometric parameters blood biochemistry panels measured. Statistical analysis using partial correlation, multivariable regression covariance performed assess impact on levels.After adjustment for age...
Abstract Background As the incidence of secretory osteoporosis has increased, bone loss, and their relationships with thyroid-stimulating hormone (TSH) have received increased attention. In this study, role TSH in metabolism its possible underlying mechanisms were investigated. Methods We analyzed serum levels free triiodothyronine (FT3), thyroxine (FT4), mineral density (BMD) 114 men normal thyroid function. addition, osteoblasts from rat calvarial samples treated different doses for...
Cytomegalovirus (CMV) is the leading cause of congenital infections worldwide and contributes to long-term sequelae in neonates children. CMV envelope glycoproteins play a vital role virus entry cell fusion. The association between polymorphisms clinical outcomes remains controversial. present study aims demonstrate distribution glycoprotein B (gB), H (gH) N (gN) genotypes congenitally (cCMV) infected symptomatic infants attempts figure out viral outcomes.Genotyping gB, gH gN was performed...
As the incidence of osteoporosis (OP) and hypercholesterolaemia in men has increased, male OP drawn more attention from clinicians worldwide. The present study sought to investigate effects cholesterol on bone. Between July 2015 October 2015, 216 (aged ≥18 years) were recruited for this cross‑sectional study. To test our clinical hypothesis, we designed two animal models: Exogenous induced by a high‑cholesterol diet (HCD) endogenous apolipoprotein E (ApoE) knockout. Finally, direct...
BackgroundThe incidence and mortality of influenza in children had risen, but data are limited on with severe virus infection China.MethodsWe conducted a retrospective case–control study collected the patients' clinical data. Clinical including demography, presentation, laboratory findings, radiologic treatment outcomes were collected. Children clinically confirmed to have Shanghai three hospitals from June 2014 2019.ResultsDuring study, 36,047 enrolled. Among them, 118 met criteria for flu....
X-linked hypophosphatemia (XLHR) is the most common genetic form of hypophosphatemic rickets (HR), which caused by phosphate regulating endopeptidase homolog (PHEX) gene mutation. At present, genotype-phenotype relationship XLHR and pathogenic role PHEX are not fully understood.
Aim . It is known that different stages of type 2 diabetes represent distinct pathophysiological changes, but how the spectrum risk factors varies at not yet clarified. Hence, aim this study was to compare effect metabolic variables on natural history diabetes. Methods A total 5,213 nondiabetic (normal glucose tolerance (NGT) and prediabetes) Chinese older than 40 years participated prospective cohort study, 4,577 completed 3-year follow-up. Glycemic status determined by standard oral test...
How nonalcoholic fatty liver disease (NAFLD) is linked to atherosclerosis still disputed. This study aimed explore the association between NAFLD and among adults in Shandong province, China.A total of 6849 individuals were enrolled final analyses for a community-based study. The relationship was evaluated after adjusting common confounding factors.Hypertension, diabetes, higher serum low-density lipoprotein cholesterol (LDL-c) level positively correlated with NAFLD. An odds ratio (OR) (95%...
Abstract Aims/Introduction Limited data are available regarding the performance of non‐high‐density lipoprotein cholesterol (non‐HDL) in predicting incident diabetes. We aimed to analyze association between non‐HDL and development diabetes, estimate cut‐off point for discriminating diabetes people with normal glucose tolerance. Materials Methods Of 3,653 middle‐aged elderly Chinese tolerance at enrollment, 1,025 men 1,805 women returned 3‐year follow up were involved final analysis. Logistic...
To validate a three-step protocol that assesses the clinical risk associated with using blood glucose monitoring systems (BGMS) in neonates for management of dysglycaemia.The validation approach included confirmation accuracy reference method National Institute Standards and Technology (NIST) standards, assessment analytical performed on whole collected from paediatric patients routinely tested heel stick capillary samples 147 new-born babies admitted to intensive care. BGMS measurements...