A5083371790- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- vaccines and immunoinformatics approaches
- Metabolism, Diabetes, and Cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Reproductive Biology and Fertility
- Adipose Tissue and Metabolism
- Immune cells in cancer
Peking University
2019-2024
Kunming Medical University
2024
Chinese Academy of Sciences
2023
Nanchang Institute of Technology
2023
Annoroad Gene Technology (China)
2020-2022
Central South University
2021
Soochow University
2021
First Affiliated Hospital of Soochow University
2021
Xiangya Hospital Central South University
2021
Chongqing University
2020-2021
Abstract Altered metabolism in cancer cells is suspected to contribute chemoresistance, but the precise mechanisms are unclear. Here, we show that intracellular ATP levels a core determinant development of acquired cross-drug resistance human colon harbor different genetic backgrounds. Drug-resistant were characterized by defective mitochondrial production, elevated aerobic glycolysis, higher absolute ATP, and enhanced HIF-1α–mediated signaling. Interestingly, direct delivery into...
The efficacy and potential limitations of molecular residual disease (MRD) detection urgently need to be fully elucidated in a larger population non-small cell lung cancer (NSCLC). We enrolled 261 patients with stages I III NSCLC who underwent definitive surgery, 913 peripheral blood samples were successfully detected by MRD assay. Within the population, only six (3.2%) longitudinal undetectable recurred, resulting negative predictive value 96.8%. Longitudinal may define cured. peak risk...
The Alzheimer's disease (AD)-associated presenilin (PS) proteins are required for the γ-secretase cleavages of β-amyloid precursor protein and site 3 (S3) protease cleavage Notch. These intramembrane release amyloid-β peptide (Aβ), including pathogenic 42-aa variant (Aβ 42 ), as well Notch intracellular domains (AICD, NICD). Whereas Aβ is generated by endoproteolysis in middle transmembrane domain, AICD NICD at analogous positions close to cytoplasmic border domain. Numerous mutations...
Presenilin 1 (PS1) is required for the proteolytic processing of Notch and β-amyloid precursor protein (APP), molecules that play pivotal roles in cell-fate determination during development Alzheimer's disease pathogenesis, respectively. In addition, PS1 interacts with β-catenin promotes its turnover through independent mechanisms. Consistent this activity, we report here important controlling epidermal cell proliferation vivo . knockout mice are rescued neuronal expression human transgene...
Familial Alzheimer's disease-associated mutations in presenilin 1 or 2 amyloid precursor protein result elevated β-amyloid, β-amyloid accumulation, and plaque formation the brains of affected individuals. By crossing transgenic mice carrying A246E mutation with plaque-producing K670N/M671L (Tg2576), we show that co-expression both mutant transgenes results acceleration accumulation associative learning deficits. At 5 months age no detectable pathology, animals are impaired contextual fear...
Excess food intake leads to obesity and diabetes, both of which are well-known independent risk factors for atherosclerosis, growing epidemics in an aging population. We hypothesized that enhances the metabolic vascular effects high fat diet (HFD) therefore examined effect age on atherosclerosis insulin resistance lipoprotein receptor knockout (LDLR −/− ) mice. found 12-month-old (middle-aged) LDLR mice developed substantially worse syndrome, than 3-month-old (young) when were fed HFD 3...
Left ventricular hypertrophy (LVH) is a common complication in patients with CKD and an independent risk factor for death. Changes the levels of uremic solutes or Klotho have been reported to be related CKD, whereas relationships between these factors CKD-associated LVH remain unclear. Here, we investigated interaction indoxyl sulfate (IS), typical solute, LVH. In survey 86 negative relationship was found serum IS (r=−0.59, P<0.001). Furthermore, were independently associated (for IS:...
Aldosterone plays a major role in the regulation of salt balance and pathophysiology cardiovascular renal diseases. Many aldosterone-regulated genes — including that encoding epithelial Na+ channel (ENaC), key arbiter transport kidney other epithelia have been identified, but mechanisms by which hormone modifies chromatin structure thus transcription remain unknown. We previously described basal repression ENaCα complex containing histone H3 Lys79 methyltransferase disruptor telomeric...
Aldosterone is a major regulator of epithelial Na+ absorption and acts in large part through induction the channel (ENaC) gene renal collecting duct. We previously identified Dot1a as an aldosterone early repressed repressor ENaCα transcription mediating histone H3 Lys-79 methylation associated with promoter. Here, we report novel aldosterone-signaling network involving AF9, Dot1a, ENaCα. AF9 interact vitro vivo evidenced multiple assays colocalize nuclei mIMCD3 duct cells. Overexpression...
Abstract Platinum nanoparticles (PtNPs) efficiently catalyze the transformation of H 2 O into oxygen gas. However, owing to lack an efficient approach or device that can measure produced gas, catalytic reaction has never been used for diagnostic applications. Microfluidics technology provides a platform meets these requirements. The volumetric bar‐chart chip (V‐Chip) volumetrically measures production gas by PtNPs and be integrated with ELISA provide visible quantitative readouts without...
Abstract Purpose: The optimal systemic treatment for pulmonary large-cell neuroendocrine carcinoma (LCNEC) is still under debate. Previous studies showed that LCNEC with different genomic characteristics might respond differently to chemotherapy regimens. In this study, we sought investigate subtyping using cell-free DNA (cfDNA) analysis in advanced and assess its potential prognostic predictive value. Experimental Design: Tumor cfDNA from 63 patients were analyzed by target-captured...
Here, we have investigated treatment resistance mechanisms in small cell lung cancer (SCLC) by focusing on comparing the genotype and phenotype tumor samples of treatment-resistant treatment-sensitive SCLC.We conducted whole-exome sequencing paired at diagnosis relapse from 11 patients with limited-stage (LS)-SCLC targeted 1,021 cancer-related genes cell-free DNA baseline relapsed 9 additional LS-SCLC. Furthermore, performed label-free mass spectrometry-based proteomics 28 chemo-resistant 23...
<h3>Background</h3> Non-alcoholic fatty liver disease (NAFLD) is characterised by accumulation of excessive triglycerides in the liver. Obesity usually associated with NAFLD through an unknown mechanism. <h3>Objective</h3> To investigate roles Yin Yang 1 (YY1) progression obesity-associated hepatosteatosis. <h3>Methods</h3> Expression levels hepatic YY1 were identified microarray analysis high-fat-diet (HFD)-induced obese mice. Liver triglyceride metabolism was analysed mice overexpression...