A5042341684- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Melanoma and MAPK Pathways
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Gut microbiota and health
- Ethics in Clinical Research
- Flavonoids in Medical Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Vascular Tumors and Angiosarcomas
- Colorectal and Anal Carcinomas
- Hippo pathway signaling and YAP/TAZ
The University of Texas MD Anderson Cancer Center
2015-2024
National Physical Laboratory
2024
Centre for Cancer Biology
2004-2023
Karolinska University Hospital
2019
Karolinska Institutet
2019
King's College London
2019
Fred Hutch Cancer Center
2019
University of Washington
2019
Spinal Cord Injury BC
2019
Baylor University
2019
To examine recurrence and survival rates for patients treated with hepatic resection only, radiofrequency ablation (RFA) plus or RFA only colorectal liver metastases.
Objective To describe the safety and efficacy of radiofrequency ablation (RFA) to treat unresectable malignant hepatic tumors in 123 patients. Background The majority patients with primary or metastatic malignancies confined liver are not candidates for resection because tumor size, location, multifocality inadequate functional reserve. Local application heat is tumoricidal; therefore, authors investigated a novel RFA system cancer. Patients Methods were entered into prospective,...
The primary goal of this study was to evaluate whether pathologic response chemotherapy predicts patient survival after preoperative and resection colorectal liver metastases (CLM). secondary the identify clinical predictors response.A retrospective review performed 305 patients who underwent irinotecan- or oxaliplatin-based chemotherapy, followed by CLM. Pathologic systematically evaluated reported as mean percentage cancer cells remaining within each tumor. Univariate multivariate analyses...
5-Fluorouracil (5FU) and oxaliplatin are standard therapy for metastatic colorectal cancer (CRC), but the development of chemoresistance is inevitable. Because stem cells (CSC) hypothesized to be chemoresistant, we investigated CSC properties in newly developed chemoresistant CRC cell lines sought identify targets therapy. The human line HT29 was exposed increasing doses 5FU (HT29/5FU-R) or (HT29/OxR) achieve resistance at clinically relevant doses. Western blotting flow cytometry were done...
Abstract Purpose: Epithelial-to-mesenchymal transition (EMT) is a process whereby cells acquire molecular alterations that facilitate cell motility and invasion. In preliminary studies, we observed oxaliplatin-resistant (OxR) colorectal cancer (CRC) underwent morphologic changes suggestive of migratory phenotype, leading us to hypothesize OxR CRC undergo EMT. Experimental Design: The human lines KM12L4 HT29 were exposed increasing doses oxaliplatin establish stable resistant oxaliplatin....
Purpose We investigated the efficacy of fluorouracil (FU), leucovorin, irinotecan, and bevacizumab (FOLFIRI + B) in a phase II trial patients previously untreated for metastatic colorectal cancer (mCRC), changes during treatment plasma cytokines angiogenic factors (CAFs) as potential markers response therapeutic resistance. Patients Methods conducted II, two-institution FOLFIRI B. Each 14-day cycle consisted (5 mg/kg), irinotecan (180 mg/m 2 ), bolus FU (400 leucovorin ) followed by 46-hour...
Representative racial/ethnic participation in research, especially clinical trials that establish standards of care, is necessary to minimize disparities outcomes and uphold societal equity health care.To evaluate the frequency race reporting proportional representation supporting US Food Drug Administration (FDA) oncology drug approvals.Database study all reported FDA approvals granted between July 2008 June 2018. Primary reports were obtained from PubMed ClinicalTrials.gov. identified...
PURPOSE: The current American Joint Committee on Cancer (AJCC) staging system for hepatocellular carcinoma (HCC) fails to stratify patients adequately with respect prognosis. PATIENTS AND METHODS: ability of the currently proposed tumor (T) categories effectively survival 557 who underwent complete resection HCC at four centers was examined. Independent predictors were combined into a new system. RESULTS: Using AJCC T classification, T1 and T2 tumors had similar 5-year survivals (P = .6). In...
See accompanying editorial on page 1186 Lee M. Ellis, University of Texas MD Anderson Cancer Center, Houston, TX; David S. Bernstein and Richard L. Schilsky, American Society Clinical Oncology, Alexandria, VA; Emile E. Voest, Medical Center Utrecht, the Netherlands; Jordan D. Berlin, Vanderbilt-Ingram Nashville, TN; Daniel Sargent, Mayo Clinic, Rochester, MN; Patricia Cortazar, US Food Drug Administration, Silver Spring, MD; Elizabeth Garrett-Mayer, South Carolina, Charleston, SC; Roy Herbst...
Abstract BACKGROUND. The current study evaluated the effect of bevacizumab added to fluoropyrimidine‐plus‐oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on pathologic response and nontumorous histology. METHODS. A total 105 consecutive patients treated preoperatively with 5FU/OX (n = 62) or without 43) were analyzed. was by analysis tumor viability (percentage viable in relation surface area). incidence grade hepatic sinusoidal dilation also investigated. RESULTS....
In Brief Background: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) late (more than days after) complication rates associated tumor RFA. Methods: All treated between January 1, 1996 June 30, 2002 RFA for malignancies were entered into database. Patients evaluated during treatment, throughout the immediate post course, then every 3...
Abstract Altered metabolism in cancer cells is suspected to contribute chemoresistance, but the precise mechanisms are unclear. Here, we show that intracellular ATP levels a core determinant development of acquired cross-drug resistance human colon harbor different genetic backgrounds. Drug-resistant were characterized by defective mitochondrial production, elevated aerobic glycolysis, higher absolute ATP, and enhanced HIF-1α–mediated signaling. Interestingly, direct delivery into...
Metastasis and drug resistance are the major limitations in survival management of patients with cancer. This study aimed to identify mechanisms underlying HT29 colon cancer cell chemoresistance acquired after sequential exposure 5-fluorouracil (5FU), a classical anticancer for treatment epithelial solid tumors. We examined its clinical relevance cohort liver metastases 5FU-based neoadjuvant chemotherapy surgery.We show that clonal 5F31 population, resistant 1 μmol/L 5FU, express typical...
Neuroendocrine tumors (NETs) arise from a variety of anatomic sites and share the capacity for production hormones vasoactive peptides. Because their perceived rarity, NETs have not historically been focus rigorous clinical research. However, diagnosed incidence has increasing, estimated prevalence in United States exceeds 100,000 individuals. The recent completion several phase III studies, including those evaluating octreotide, sunitinib, everolimus, demonstrated that evaluation novel...
Abstract Epithelial–mesenchymal transition ( EMT ) is a critical process providing tumor cells with the ability to migrate and escape from primary metastasize distant sites. Recently, was shown be associated cancer stem cell CSC phenotype in breast cancer. Snail transcription factor that mediates number of types, including colorectal CRC ). Our study done determine role mediating function . Human specimens were stained for expression, human lines transduced retroviral construct or vector...