A5100730364- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
- Multiple Sclerosis Research Studies
- Quantum optics and atomic interactions
- Autoimmune Neurological Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Cerebral Venous Sinus Thrombosis
- interferon and immune responses
- Cold Atom Physics and Bose-Einstein Condensates
- Cancer-related molecular mechanisms research
- Gastrointestinal motility and disorders
- Bone health and osteoporosis research
- Genetic Associations and Epidemiology
- Brain Metastases and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Quantum Information and Cryptography
- Enhanced Recovery After Surgery
- Traditional Chinese Medicine Analysis
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
Second Affiliated Hospital of Guangzhou Medical University
2024-2025
Guangzhou Medical University
2020-2025
Public Health Clinical Center of Chengdu
2025
Beijing University of Technology
2022-2024
Southwest Medical University
2024
Jiangsu T-mab BioPharma (China)
2024
Southern Medical University
2016-2024
Nanfang Hospital
2016-2024
Tianjin Medical University General Hospital
2023-2024
Zhejiang University
2024
Abstract Altered metabolism in cancer cells is suspected to contribute chemoresistance, but the precise mechanisms are unclear. Here, we show that intracellular ATP levels a core determinant development of acquired cross-drug resistance human colon harbor different genetic backgrounds. Drug-resistant were characterized by defective mitochondrial production, elevated aerobic glycolysis, higher absolute ATP, and enhanced HIF-1α–mediated signaling. Interestingly, direct delivery into...
Abstract Breast cancer brain metastasis is resistant to therapy and a particularly poor prognostic feature in patient survival. Altered metabolism common of cells, but little known as what metabolic changes benefit breast metastases. We found that metastatic cells evolved the ability survive proliferate independent glucose due enhanced gluconeogenesis oxidations glutamine branched chain amino acids, which together sustain nonoxidative pentose pathway for purine synthesis. Silencing...
Abstract Motivation: The underlying relationship between genomic factors and the response of diverse cancer drugs still remains unclear. A number studies showed that heterogeneous responses to anticancer treatments patients were partly associated with their specific changes in gene expression somatic alterations. emerging large-scale pharmacogenomic data provide us valuable opportunities improve existing therapies or guide early-phase clinical trials compounds under development. However, how...
A metal-free intramolecular tandem sequence involving alkoxylation, Claisen rearrangement and lactone expansion has been achieved.
OBJECTIVE The plasma proteome preceding diabetes can improve our understanding of pathogenesis. RESEARCH DESIGN AND METHODS In 8,923 Atherosclerosis Risk in Communities (ARIC) Study participants (aged 47–70 years, 57% women, 19% Black), we conducted discovery and internal validation for associations 4,955 proteins with incident diabetes. We externally validated results the Singapore Multi-Ethnic Cohort (MEC) nested case-control (624 case subjects, 1,214 control subjects). used Cox regression...
Abstract Spinal cord injury (SCI) is a severe neurological disorder that causes impairment and disability. Neural stem/progenitor cells (NS/PCs) derived from induced pluripotent stem (iPSCs) represent promising cell therapy strategy for spinal regeneration repair. However, iPSC-derived NS/PCs face many challenges issues in SCI therapy; one of the most significant epigenetic regulation factors influence this mechanism. Epigenetics refers to gene expression function by DNA methylation, histone...
Bexagliflozin and dapagliflozin are sodium-glucose cotransporter-2 (SGLT2) inhibitors. No direct comparison of SGLT2 inhibitors in a randomized controlled trial has been reported to date. This was multicenter, randomized, double-blind, active-controlled comparing bexagliflozin for the treatment type 2 diabetes mellitus adults with disease inadequately by metformin. Subjects (n = 406) were receive (20 mg) or (10 plus The primary endpoint noninferiority change glycated hemoglobin (HbA1c) from...
Per- and polyfluoroalkyl substances (PFAS) are a group of environmental contaminants associated with various health risks; however, their relationship all-cause mortality in individuals diabetes remains unclear. A total 1256 participants from the National Health Nutrition Examination Survey (NHANES) were included to explore association between seven PFAS compounds diabetic patients. Preliminary logistic regression identified three (perfluorooctanoic acid [PFOA], perfluorooctane sulfonic...
Abstract Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently discovered autoimmune syndrome associated with psychosis, dyskinesia, and seizures. However, the underlying mechanisms of this disease remain unclear, in part because lack suitable animal models. Methods This study describes novel female C57BL/6 mouse model anti-NMDAR that was induced by active immunization against NMDARs using an amino terminal domain (ATD) peptide from GluN1 subunit (GluN1 356–385 )....
With the rapid development of biotechnology, multi-dimensional genomic data are available for us to study regulatory associations among multiple levels. Thus, it is essential develop a tool identify not only modular patterns from levels, but also relationships these modules. In this study, we adopt novel non-negative matrix factorization framework (NetNMF) integrate pairwise in network manner. NetNMF could reveal modules each dimension and connections within between both types We first...
Osteoblast and adipocyte are derived from common mesenchymal progenitor cells. The bone loss of osteoporosis is associated with altered differentiation an osteoblastic to adipocytic lineage. In this study, a comparative analysis gene expression profiling using cDNA microarray realtime-PCR indicated that Zinc finger protein 467 (Zfp467) involved in osteoblast cultured adipose stem cells (ADSCs). Our results showed RNA interference for Zfp467 ADSCs inhibited formation stimulated commitment....
We investigate the two-dimensional (2D) and three-dimensional (3D) atom localization behaviors via spontaneously generated coherence in a microwave-driven four-level atomic system. Owing to space-dependent atom-field interaction, it is found that detecting probability precision of 2D 3D can be significantly improved adjusting system parameters, phase, amplitude, initial population distribution. Interestingly, localized volumes are substantially smaller than cubic optical wavelength. Our...
Abstract β-defensin family plays a role in host defense against viral infection, however its HCV infection is still unknown. In this study, we demonstrated that 1 was significantly reduced HCV-infected liver specimens. Treatment with interferon and ribavirin upregulated β-defensin-1, but not other tested, the extent duration of upregulation associated treatment response. We investigated expression cancer publicly available datasets found among all β-defensins only downregulated, suggesting...
The high-mobility group nucleosome-binding domain 5 (HMGN5) is a member of the proteins family. Previous study found that HMGN5 required for tumorigenesis in vitro, and aberrations expression were human osteosarcoma, prostate cancer, squamous cell carcinoma. Nevertheless, role breast cancer remains unclear. This aimed to investigate clinical significance confirm oncogenic HMGN5, explore mechanism by which contributes invasion metastasis. was detected tissues corresponding adjacent...