A5111877385- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Catalysis and Hydrodesulfurization Studies
- Catalysts for Methane Reforming
- Blood Coagulation and Thrombosis Mechanisms
- Catalytic Processes in Materials Science
- PI3K/AKT/mTOR signaling in cancer
- Brain Metastases and Treatment
- Cancer Mechanisms and Therapy
- Nuclear Receptors and Signaling
- Polymer crystallization and properties
- Glioma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Alzheimer's disease research and treatments
- Carbon dioxide utilization in catalysis
- S100 Proteins and Annexins
- Process Optimization and Integration
- Antimicrobial Peptides and Activities
- Electrocatalysts for Energy Conversion
- Retinal Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Endoplasmic Reticulum Stress and Disease
- Endodontics and Root Canal Treatments
- Prion Diseases and Protein Misfolding
Seoul National University
2024
Ulsan National Institute of Science and Technology
2020-2024
The University of Texas MD Anderson Cancer Center
2012-2014
Cheil General Hospital and Women's Healthcare Center
2013
Catholic Kwandong University
2013
Korea Research Institute of Bioscience and Biotechnology
2013
Sungkyunkwan University
2013
Korea University
2012
Yonsei University
2008
Ewha Womans University
2005
Abstract Breast cancer brain metastasis is resistant to therapy and a particularly poor prognostic feature in patient survival. Altered metabolism common of cells, but little known as what metabolic changes benefit breast metastases. We found that metastatic cells evolved the ability survive proliferate independent glucose due enhanced gluconeogenesis oxidations glutamine branched chain amino acids, which together sustain nonoxidative pentose pathway for purine synthesis. Silencing...
Monodisperse nanoparticles (NPs) of CoFe2O4 were synthesized as efficient catalyst precursors for CO2 hydrogenation to produce high value-added C2–C4 olefin products, which are important building blocks the chemical industry. The resulting Na-promoted catalysts supported on carbon nanotubes (Na–CoFe2O4/CNT) exhibited conversion (∼34%) and light selectivity (∼39%), outperforming other reported Fe-based under similar reaction conditions. Their performance was superior that single-metal NP...
Recent evidence suggests that astrocytes protect cancer cells from chemotherapy by stimulating upregulation of anti-apoptotic genes in those cells. We investigated the possibility activation endothelin axis orchestrates survival gene expression and chemoprotection MDA-MB-231 breast H226 lung cells.Cancer cells, murine astrocytes, fibroblasts were grown isolation, (ET) peptides ET receptors (ETAR ETBR) compared with on (or fibroblasts) co-incubated for 48 hours. Type-specific receptor...
Summary Introduction Oleandrin, a cardiac glycoside, exerts strong anti-proliferative activity against various human malignancies in vitro cells. Here, we report the antitumor efficacy of PBI-05204, supercritical C0 2 extract Nerium oleander containing oleandrin, pancreatic cancer Panc-1 orthotopic model. Results While all control mice exhibited tumors by end treatment, only 8 (25 %) treated for 6 weeks with PBI-05204 (40 mg/kg) showed dissectible tumor at treatment period. The average...
The foreign cation substitution approach to Ni-Co spinel oxide promotes the active NiOOH species formation, resulting in remarkable electrochemical glycerol oxidation activity and selectivity for formate production. generated NiOOH...
Circulating endothelial cells (CEC) have been widely used as a prognostic biomarker and regarded promising strategy for monitoring the response to treatment in several cancers. However, presence biologic roles of CECs remained controversial decades because technical standards identification quantification not established. Here, we hypothesized that detected by flow cytometry might be monocytes rather than cells.The frequency representative CEC subsets (i.e., CD45(-)/CD31(+),...
Abstract The formation of hepatic metastases in colorectal cancer is the main cause patient death. Current therapies directed at metastasis have had minimal impact on outcome. Therefore, alternative treatment strategies for liver require development. present study was performed to evaluate application cDNA LK68 encoding apolipoprotein(a) kringles IV-9, IV-10, and V as possible candidates gene therapy this life-threatening disease. murine cell line CT26 transduced ex vivo with via retroviral...
The formation of liver metastases in colorectal cancer patients is the primary cause patient death. Current therapies directed at metastasis from have had minimal impact on outcomes. Therefore, development alternative treatment strategies for needed. In present study, we demonstrated that recombinant human apolipoprotein(a) kringle V, also known as rhLK8, induced apoptotic turnover endothelial cells vitro through mitochondrial apoptosis pathway. interaction rhLK8 with glucose-regulated...
Catalytic CO2 hydrogenation facilitated by Fe3O4 produces long-chain hydrocarbons and light olefins through the combination of reverse water–gas shift reaction Fischer–Tropsch synthesis in a single reactor. Complementing Fe3O4-based catalysts, zeolites can be incorporated to modulate product distribution dual-bed configuration. However, with strong acid sites induce cracking extended hydrocarbon chains, thereby impeding production exceeding 12 carbon atoms. This paper introduces novel...
Antivascular therapy has emerged as a rational strategy to improve the treatment of androgen-independent prostate cancer owing necessity establishing vascular network for growth and progression primary metastatic tumor. We determined whether recombinant human apolipoprotein(a) kringle V, rhLK8, produces therapeutic efficacy in an orthotopic animal model. Fifty thousand cells (PC-3MM2) were injected into nude mice. After 3 days, these mice randomized receive vehicle solution...
Abstract Many proteins in the fibrinolysis pathway contain antiangiogenic kringle domains. Owing to high degree of homology between domains, there has been a safety concern that kringles could interact with common during leading adverse effects vivo . To address this issue, we investigated several including angiostatin, apolipoprotein(a) IV 9 -IV 10 -V (LK68), V (rhLK8) and derivative rhLK8 mutated produce functional lysine-binding site (Lys-rhLK8) on entire fibrinolytic process vitro...