A5100660556- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Histone Deacetylase Inhibitors Research
- Cell death mechanisms and regulation
- Protein Degradation and Inhibitors
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- Kruppel-like factors research
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Extracellular vesicles in disease
- Acute Lymphoblastic Leukemia research
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Cancer therapeutics and mechanisms
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Computational Drug Discovery Methods
- Research on Leishmaniasis Studies
- Fetal and Pediatric Neurological Disorders
- Lung Cancer Treatments and Mutations
Shanghai University
2025
Jiangnan University
2025
Shanghai Jiao Tong University
2012-2025
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
Chinese PLA General Hospital
2024
Guangxi University of Chinese Medicine
2020-2023
State Key Laboratory of Biotherapy
2020
Women's Hospital, School of Medicine, Zhejiang University
2014-2017
Ministry of Education of the People's Republic of China
2017
Abstract Background Bruton tyrosine kinase (BTK) inhibitors have demonstrated a high degree of efficacy in the treatment B cell malignancies characterized by constitutive receptor activation, including chronic lymphocytic leukemia/small lymphoma (CLL/SLL). Methods The and safety zanubrutinib, an investigational highly selective BTK inhibitor, was evaluated this single-arm, phase 2 study Chinese patients with relapsed/refractory CLL/SLL. primary endpoint overall response rate as assessed...
Multiple myeloma (MM) is the second most common hematologic neoplasms and an appropriate in vivo environment for cells has potential implications initiation, progression, metastasis of MM. Exosomes, entities carrying microRNAs (miRNAs) to target locations, participate cross-talk between nonmalignant components environment. This study disclosed emerging roles circulating exosome-associated miRNAs drug resistance (DR) To this end, medical records consecutively hospitalized MM patients, who...
// Jianyong Li 1,2,* , Yaoyu Chen Yu Zhu 1,2 Jianfeng Zhou 3 Yanli Xu 4 Yan 5 Kang 6 Ling Pan 7 Jianmin Wang 8 Jiahua Ding 9 Jian Gu 10 Shanhua 11 Jinning Shi 12 Ming Hong Ji Liangqin Limin Duan Run Zhang Sujiang Huayuan Hua Lu Peng Liu Hongxia Qiu Hanxin Wu and Sixuan Qian 1 First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China 2 Collaborative Innovation Center for Cancer Personalized Medicine, Tongji affiliated to medical college Huazhong...
With the rapid development of modern medicine, therapeutic schedules brain-metastasized non-small cell lung cancer (NSCLC) are expanding. To assist a patient who suffers from NSCLC to select most suitable schedule, firstly, we establish an indicator system for evaluating schedules; then, propose probabilistic linguistic ELECTRE II method handle corresponding evaluation problem following reasons: (1) information is effective depict uncertainty process and fuzziness expert’s cognition; (2) can...
Abstract Background Aponermin, a circularly permuted tumor necrosis factor-related apoptosis-inducing ligand, is potential death receptor 4/5-targeted antitumour candidate. Previous phase 1/2 studies have demonstrated the efficacy of aponermin in patients with relapsed or refractory multiple myeloma (RRMM). To confirm superiority plus thalidomide and dexamethasone (aponermin group) over placebo (placebo RRMM, randomized, double-blinded, controlled 3 trial was performed. Methods Four hundred...
In the digital age, in order to solve problems of illusion, timeliness, data security, etc. large language model technology (LLM), retrieval-augmented generation (RAG) has emerged as a feasible solution. Therefore, architecture concept LLM+RAG was proposed, assist design work an efficient AI tool. this paper adopts layered design, and realizes end-to-end process from professional knowledge acquisition intelligent suggestion through six core functional layers: base construction layer,...
Exercise induces molecular changes that involve multiple organs and tissues. Moreover, these are modulated by various exercise parameters-such as intensity, frequency, mode, duration-as well clinical features like gender, age, body mass index (BMI), each eliciting distinct biological effects. To assist researchers in understanding from a comprehensive perspective includes organs, diverse regimens, range of features, we developed Regulated Genes Database (ExerGeneDB), database...
Abstract Multiple myeloma (MM) is an aggressive malignancy characterized by terminally differentiated plasma cells accumulation in the bone marrow (BM). MM BM exhibits elevated MΦs (macrophages) numbers relative to healthy BM. Current evidence indicates that MM-MΦs (MM-associated macrophages) have pro-myeloma functions, and negatively correlate with patient survival. Here, we found BMI1, a polycomb-group protein, modulates functions of MM-MΦs, which expressed higher BMI1 levels normal MΦs....
Osteoblast and adipocyte are derived from common mesenchymal progenitor cells. The bone loss of osteoporosis is associated with altered differentiation an osteoblastic to adipocytic lineage. In this study, a comparative analysis gene expression profiling using cDNA microarray realtime-PCR indicated that Zinc finger protein 467 (Zfp467) involved in osteoblast cultured adipose stem cells (ADSCs). Our results showed RNA interference for Zfp467 ADSCs inhibited formation stimulated commitment....
Despite the recent development of new therapies, multiple myeloma (MM) remains an incurable disease. Thus, new, effective treatments are urgently needed, particularly for relapsed or refractory MM (RRMM). In earlier phase I study, a novel form recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) that is currently in clinical treatment hematologic malignancies, i.e., circularly permuted TRAIL (CPT), was well tolerated at dose 2.5 mg/kg per day and showed...
Background: Previous research suggested that single gene expression might be correlated with acute myeloid leukemia (AML) survival.Therefore, we conducted a systematical analysis for AML prognostic expressions. Methods:We performed microarray-based correlations between and adult overall survival (OS) using datasets GSE12417 GSE8970.Positive findings were validated in an independent cohort of 50 newly diagnosed, non-acute promyelocytic (APL) patients by quantitative RT-PCR analysis.Results:...
BACKGROUND:The aim of this study was to show whether the standardized Ginkgo biloba extract EGb761, a traditional Chinese medicine, has therapeutic effect on pulmonary fibrosis (PF). MATERIAL AND METHODS:Bleomycin (BLM) used for establishing PF mouse model. The mice were treated with gradient EGb761 28 days determine an appropriate drug dose. On day 28, lung injury and inflammation confirmed by hematoxylin eosin Masson staining evaluated alveolitis Ashcroft score. balance M1/M2 macrophages...
ABSTRACT Objective The aim of this study is to report the clinical application noninvasive prenatal testing (NIPT) detect chromosomal aneuploidies, especially trisomies 21, 18, and 13 in Chinese singleton pregnancies. Methods Pilot validation between NIPT with full karyotyping was conducted blindly on 306 cases. Subsequently, 7705 pregnancies were offered NIPT. Follow‐up data obtained all Results In stage, a total five positive cases observed for 21 results confirmed by karyotyping; there no...