A5073461890- Retinal Diseases and Treatments
- Metabolomics and Mass Spectrometry Studies
- Folate and B Vitamins Research
- Arsenic contamination and mitigation
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- Peroxisome Proliferator-Activated Receptors
- HIV/AIDS Research and Interventions
- Cardiac pacing and defibrillation studies
- Birth, Development, and Health
- Retinal Imaging and Analysis
- Cardiac Arrhythmias and Treatments
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Neurological disorders and treatments
- Heavy Metal Exposure and Toxicity
- Gestational Diabetes Research and Management
- Fatty Acid Research and Health
- Diet and metabolism studies
- Vitamin K Research Studies
- Climate Change and Health Impacts
- Vitamin C and Antioxidants Research
- HIV Research and Treatment
Wenzhou Medical University
2013-2024
National Clinical Research Center for Digestive Diseases
2021-2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Affiliated Eye Hospital of Wenzhou Medical College
2016-2023
Array Information Technology (United States)
2023
Johns Hopkins University
2014-2017
Anhui Medical University
2005-2015
Yale University
2008
Objectives His bundle pacing (HBP) can potentially correct left branch block (LBBB). We aimed to assess the efficacy of HBP LBBB and long-term clinical outcomes with in patients heart failure (HF). Methods This is an observational study HF typical who were indicated for therapy consecutively enrolled from one centre. Permanent leads implanted if correction threshold was <3.5V/0.5 ms or 3.0 V/1.0 ms. Pacing parameters, ventricular ejection fraction (LVEF), end-systolic volume (LVESV) New...
OBJECTIVE—The purpose of this study was to investigate whether genetic variants could influence the antidiabetic efficacy gliclazide in type 2 diabetic patients. RESEARCH DESIGN AND METHODS—A total 1,268 patients whose diabetes diagnosed within past 5 years and who had no recent hypoglycemic treatment were enrolled from 23 hospitals China. All treated with for 8 weeks. Fasting oral glucose tolerance test 2-h plasma glucose, fasting insulin, A1C measured at baseline after weeks treatment. We...
Background:Prenatal exposure to ambient PM2.5, (i.e., fine particulate matter, aerodynamic diameter ≤ 2.5 μm) has been associated with preterm birth and low weight. The association between prenatal PM2.5 intrauterine inflammation (IUI), an important risk factor for neurodevelopmental outcomes, not evaluated.Objectives:We aimed investigate the maternal IUI in Boston Birth Cohort, a predominantly urban low-income minority population.Methods:This analysis included 5,059 mother–infant pairs...
Background: Although previous studies suggest that exposure to traffic-related pollution during childhood increases the risk of overweight or obesity (COWO), role early life fine particulate matter (aerodynamic diameter <2.5μm; PM2.5) and its joint effect with mother's prepregnancy body mass index (MPBMI) on COWO remain unclear. Objectives: The present study was conducted examine individual effects ambient PM2.5 exposures MPBMI COWO. Methods: We estimated in utero first 2 y (F2YL), using...
To investigate the independent and joint associations of hyperhomocysteinemia hypertension with incident stroke death in Chinese adults.About 39,165 rural adults aged 35 years or older who had no history at baseline study were prospectively followed to determine major cardiovascular events, an average follow-up 6.2 years. Using a nested case-control design, this report includes 179 cases (121 deaths) controls without vascular events from original cohort matched by age, sex, community, length...
Abstract This study aimed to investigate the optimal degree of weight gain across gestational spectrum in 1971 children enrolled at birth and followed up age 7 years. Weight infancy was categorized into four groups based on z -scores: slow (<−0.67), track (−0.67 0.67), rapid (0.67 1.28), extremely (>1.28). Underweight overweight or obesity (OWO) were defined as a body mass index ≤5 th ≥85 percentile, respectively, for gender. In our population, OWO far more common than underweight...
Introduction Despite advances in diabetic retinopathy (DR) medications, early identification is vitally important for DR administration and remains a major challenge. This study aims to develop novel system of multidimensional network biomarkers (MDNBs) based on widely targeted metabolomics approach detect among patients with type 2 diabetes mellitus (T2DM) efficiently. Research design methods In this propensity score matching-based case-control study, we used ultra-performance liquid...
Abstract Preterm birth (PTB) contributes significantly to infant mortality and morbidity with lifelong impact. Few robust genetic factors of PTB have been identified. Such ‘missing heritability’ may be partly due gene × environment interactions (G E), which is largely unexplored. Here we conduct genome-wide G E analyses in 1,733 African-American women (698 mothers PTB; 1,035 term birth) from the Boston Birth Cohort. We show that maternal COL24A1 variants a significant interaction...
Background and Objectives. Diabetic kidney disease is a leading cause of chronic end-stage renal across the world. Early identification DKD vitally important for effective prevention control it. However, available indicators are doubtful in early diagnosis DKD. This study aimed at determining novel sensitive specific biomarkers to distinguish from their counterparts effectively based on widely targeted metabolomics approach. Materials Method. case-control involved 44 T2DM patients. Among...
Accurate forecast of the death risk is crucial to administration people living with HIV/AIDS (PLHIV). We aimed establish and validate an effective prognosis nomogram in PLHIV receiving antiretroviral therapy (ART).All data were obtained from 2006 2018 Wenzhou area China AIDS prevention control information system. Factors included determined by univariate multiple Cox proportional hazard analysis based on training set. The receiver operating characteristic (ROC) calibration curves used assess...
Abstract Objective Early identification of diabetic retinopathy (DR) is key to prioritizing therapy and preventing permanent blindness. This study aims propose a machine learning model for DR early diagnosis using metabolomics clinical indicators. Methods From 2017 2018, 950 participants were enrolled from two affiliated hospitals Wenzhou Medical University Anhui University. A total 69 matched blocks including healthy volunteers, type 2 diabetes, patients obtained propensity score...
Background: Diabetic retinopathy (DR) is a major diabetes-related disease linked to metabolism. However, the cognition of metabolic pathway alterations in DR remains scarce. We aimed corroborate pathways identified prior studies and investigate novel dysregulations that may lead new prevention treatment strategies for DR. Methods: In this case-control study, we tested 613 serum metabolites 69 pairs type 2 diabetic patients (T2DM) with propensity score-matched T2DM without via...
Chronic arsenic exposure via drinking water has become a worldwide public health concern. In humans, inorganic (iAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic (DMA) mainly mediated by (+3 oxidation state) methyltransferase (As3MT). We reported recently that N-6 adenine-specific DNA 1 (N6AMT1) was involved in metabolism, examined its interactive effect with As3MT on metabolism vitro. To further evaluate the of N6AMT1 biomethylation we conducted human population-based...
•Myopia onset was closely related to ocular indicators.•Single spherical equivalent refraction performed poorly in predicting myopia among Chinese schoolchildren.•An online risk calculator developed predict incident schoolchildren. PurposeMyopia is a major public health issue and occurs at young ages. Apart from its high prevalence, results costs irreversible blinding diseases. Accurate prediction of the crucial for precise prevention. We aimed develop validate an effective nomogram...
Abstract Background As a DNA surveillance mechanism, cell cycle checkpoint has recently been discovered to be closely associated with lung adenocarcinoma (LUAD) prognosis. It is also an essential link in the process of damage repair (DDR) that confers resistance radiotherapy. Whether genes have both functions play more crucial role LUAD prognosis remains unclear. Methods In this study, DDR-related function (DCGs) were selected investigate their effects on LUAD. The TCGA-LUAD cohort and two...
Although previous studies have suggested that hemoglobin is related to the health status of people living with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) (PLWHA), role anemia in mortality remains unclear. This study aimed comprehensively quantify effect on risk PLWHA. In this retrospective cohort study, we thoroughly estimated PLWHA mortality, using data collected from January 2005 June 2022 Huzhou area, 450 subjects extracted database China Disease...
Although previous reports have linked DNA damage with both transmissions across generations as well our own survival, it is unknown how to reverse the lesion. Based on data from a Randomized, Double-blind, Placebo Controlled Clinical Trial, this study aimed assess efficacy of folic acid supplementation (FAS) oxidative reversal. In randomized clinical trial (RCT), total 450 participants were enrolled and randomly assigned 3 groups receive (FA) 0.4 mg/day (low-FA), 0.8 (high-FA), or placebo...