A5031559341- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- Birth, Development, and Health
- Pregnancy and Medication Impact
- Anesthesia and Neurotoxicity Research
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Prenatal Screening and Diagnostics
- Neuroscience of respiration and sleep
- Mosquito-borne diseases and control
- Pregnancy-related medical research
- Reproductive tract infections research
- Assisted Reproductive Technology and Twin Pregnancy
- Fetal and Pediatric Neurological Disorders
- Viral Infections and Vectors
- Neonatal and Maternal Infections
- Maternal and Perinatal Health Interventions
- Infant Nutrition and Health
- Immune Response and Inflammation
- Gestational Diabetes Research and Management
- Congenital Heart Disease Studies
University of Maryland, Baltimore
2022-2025
Johns Hopkins University
2015-2024
Johns Hopkins Medicine
2015-2024
Johns Hopkins Bayview Medical Center
2022-2024
Johns Hopkins Hospital
2016-2024
University of Maryland, College Park
2023
Society for Maternal-Fetal Medicine
2022
Waldorf College
2022
Landwirtschaftlichen Zentrums Baden-Württemberg
2022
Hudson Institute
2022
Abstract Exposure to prenatal inflammation is a known risk factor for long term neurobehavioral disorders including cerebral palsy, schizophrenia, and autism. Models of systemic during pregnancy have demonstrated an association with immune response adverse outcomes the exposed fetus. Yet, most common route inflammatory exposure fetus from intrauterine as occurs chorioamnionitis. The aims this study were assess effect on fetal neonatal brain development determine if gestational age altered...
BACKGROUND: Among women with hypertensive disorders of pregnancy, biomarkers may stratify risk for developing preeclampsia severe features (sPE). METHODS: Across 18 U.S. centers, we prospectively measured the ratio serum soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) in pregnant hospitalized between 23 and 35 weeks gestation. The primary outcome was predicting sPE, secondary outcomes included adverse within 2 weeks. prognostic performance sFlt-1:PlGF assessed...
Zika virus (ZIKV) crosses the placenta and causes congenital disease. Here we develop an animal model utilizing direct ZIKV inoculation into uterine wall of pregnant, immunocompetent mice to evaluate transplacental transmission. Intrauterine at embryonic day (E) 10, but not E14, with African, Asian or American strains reduces fetal viability increases infection placental tissues. E10 inflammation, dysfunction neonatal brain cortical thickness, which is associated increased activation...
Abstract Adverse neurological outcome is a major cause of long‐term morbidity in ex‐preterm children. To investigate the effect parturition and inflammation on fetal brain, we utilized two vivo mouse models preterm birth. mimic most common human scenario birth, used model intrauterine by infusion lipopolysaccharide (LPS). immature absence inflammation, non‐infectious birth administering RU486. Pro‐inflammatory cytokines (IL‐10, IL‐1β, IL‐6 TNF‐α) amniotic fluid inflammatory biomarkers...
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 12 million infections and more than 550 000 deaths.
Assisted reproductive technologies (ART) have been associated with several adverse perinatal outcomes involving placentation and fetal growth. It is critical to examine each intervention individually in order assess its relationship the described outcomes. One ubiquitously used ART superovulation gonadotropins. Superovulation results significant changes hormonal milieu, which persist during peri-implantation early periods. Epidemiologic evidence suggests that treatment-induced maternal...
Problem Exposure to intrauterine inflammation, associated with preterm birth, has been linked a devastating spectrum of neurobehavioral disorders. Mechanisms this injury are unknown. Using mouse model we have observed disruption fetal neuronal morphology along marked elevation interleukin ( IL )‐1β in the brain and placenta. In study, hypothesized that ‐1 plays key role perinatal injury. Method study Utilizing inflammation‐induced investigated cortical as well birth. these studies, dams...
Timing and initiation of labor are well-orchestrated by signals communicated between the fetal maternal compartments; however, how these is not completely understood. Fetal exosomes, intercellular signaling vesicles, may play a key role in process. The objective this study was to evaluate exosome trafficking vivo from compartments. Pregnant CD-1 mice were intra-amniotically injected on gestational day 16 17 with exosomes isolated primary human amnion epithelial cells fluorescently labeled...
Preterm birth is a major risk factor for adverse neurological outcomes in ex-preterm children, including motor, cognitive, and behavioral disabilities. N-acetyl-L-cysteine therapy has been used clinical studies; however, it requires doses that cause significant side effects. In this study, we explore the effect of low dose therapy, delivered using targeted, systemic, maternal, dendrimer nanoparticle (DNAC), mouse model intrauterine inflammation. Our results demonstrated intraperitoneal...
Vaginally delivered nanoformulations of progesterone and histone deacetylase inhibitors prevent inflammation-induced preterm birth in mice.
Abstract The decline of CD8 + T cell functions contributes to deteriorating health with aging, but the mechanisms that underlie this phenomenon are not well understood. We use single-cell RNA sequencing both cross-sectional and longitudinal samples assess how human heterogeneity transcriptomes change over nine decades life. Eleven subpopulations cells their dynamic changes age identified. Age-related in gene expression result from percentage expressing a given transcript, quantitative...
To estimate the diagnostic accuracy of electronic fetal heart rate abnormalities in identification neonates with encephalopathy treated whole-body hypothermia.