A5025781896- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- Reproductive tract infections research
- Neonatal and fetal brain pathology
- Homelessness and Social Issues
- Syphilis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Health disparities and outcomes
- LGBTQ Health, Identity, and Policy
- Food Security and Health in Diverse Populations
- Neonatal Respiratory Health Research
- Data-Driven Disease Surveillance
- Health Policy Implementation Science
- Intimate Partner and Family Violence
- Focus Groups and Qualitative Methods
- Cardiac Arrest and Resuscitation
- Privacy, Security, and Data Protection
- Reproductive Health and Contraception
- Mobile Health and mHealth Applications
- Substance Abuse Treatment and Outcomes
- HIV Research and Treatment
- Adolescent and Pediatric Healthcare
- Congenital Heart Disease Studies
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2016-2025
University of Baltimore
2013-2024
Chase Brexton Health Care
2022
Johns Hopkins Bayview Medical Center
2006-2021
Baltimore City Health Department
2017-2020
Indiana University Bloomington
2020
The Centers
2018
Pediatrics and Genetics
2018
Cornell University
2017
Disease variation can be substantial even in conditions with a single gene etiology such as cystic fibrosis (CF). Simultaneously studying the effects of genes and environment may provide insight into causes variation.To determine whether secondhand smoke exposure is associated lung function other outcomes individuals CF, socioeconomic status affects relationship between disease severity, specific gene-environment interactions influence effect on function.Retrospective assessment function,...
Background It is often assumed that local sexual networks play a dominant role in HIV spread sub-Saharan Africa. The aim of this study was to determine the extent which continued transmission rural communities—home two-thirds African population—is driven by intra-community versus viral introductions from outside communities. Methods and Findings We analyzed spatial dynamics Rakai District, Uganda, using data cohort 14,594 individuals within 46 applied clustering statistics, phylogenetics,...
Geographic approaches to sexually transmitted infection (STI) research frequently seek identify areas where outreach STI testing may most effectively interrupt continued transmission of STIs. Many the studies are limited, however, in that they fail control for racial/ethnic composition high prevalence areas. These thus be merely identifying broader sexual networks morbidity population and not within them. Cluster detection analysis an appropriate approach critical disease locations. This...
CONTEXT: Important barriers to STD testing may include individuals' perceptions of STD‐related stigma (negative societal attitudes toward infection) and expectations shame personal feelings) that would result from a positive test. Obtaining clear understanding the relationship between stigma, help inform programs policies aimed at reducing transmission. METHODS: Measures derived previously published scales were used assess perceived anticipated receipt an test in past year urban, household...
<h3>Objectives</h3> To estimate whether home visitation beginning after childbirth was associated with changes in average rates of mothers' intimate partner violence (IPV) victimization and perpetration as well specific IPV types (physical assault, verbal abuse, sexual injury) during the 3 years program implementation long-term follow-up. <h3>Design</h3> Randomized controlled trial. <h3>Setting</h3> Oahu, Hawaii. <h3>Participants</h3> Six hundred forty-three families an infant at high risk...
Neurodevelopmental disabilities persist in survivors of neonatal hypoxic-ischemic encephalopathy (HIE) despite treatment with therapeutic hypothermia. Cerebrovascular autoregulation, the mechanism that maintains cerebral perfusion during changes blood pressure, may influence outcomes. Our objective was to describe relationship between acute autoregulatory vasoreactivity and neurodevelopmental outcomes at 2 years age. In a pilot study 28 neonates HIE, we measured hemoglobin volume index (HVx)...
Introduction: Housing insecurity is increasingly commonplace among disadvantaged women and children. We measured the individual- population-level impact of severe housing during pregnancy on adverse birth infant outcomes. Methods: analyzed data from 3428 mother–infant dyads enrolled in Fragile Families Child Wellbeing Study, a prospective cohort study representing births 20 large U.S. cities 1998 to 2000. Severe was defined as threatened eviction or homelessness pregnancy. Outcomes included...
Background: Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and these relationships affected by birth asphyxia or vary anatomic region. Methods: Neonates cooled HIE received near-infrared spectroscopy monitoring to identify the mean arterial blood pressure optimized autoregulatory function (MAPOPT). Blood deviation from...
Abstract Background: There are no guidelines and multiple devices available now for closure of PDA. Objective: We sought to determine which used their outcomes. Methods: Prospectively collected data on PDA at 12 US catheterization labs was entered into the MAGIC registry between November 2005 September 2008. Results: accomplished in 357 359 attempted closures during study period. Mean age, weight, minimum ductal diameter were 4.3 ± 6.8 years, 18.7 18.4 kg, 2.1 1.4 mm, respectively. Devices...
To estimate the diagnostic accuracy of electronic fetal heart rate abnormalities in identification neonates with encephalopathy treated whole-body hypothermia.
Objective: This research examined whether publicly funded drug treatment centers (DTCs) were associated with violent crime in excess of the violence happening around other commercial businesses. Method: Violent data and locations community entities geocoded mapped. DTCs retail outlets matched based on a Neighborhood Disadvantage score at census tract level. Street network buffers ranging from 100 to 1,400 feet placed each location. Negative binomial regression models used estimate...
<h3>BACKGROUND AND PURPOSE:</h3> Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of brain, a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate worse autoregulatory function. <h3>MATERIALS METHODS:</h3> Thirty-one were enrolled. scalars measured 27 (age range, 4–15...
Background While there are overwhelming data supporting the association between alcohol outlet density and violent crime, remain conflicting findings about whether on‐ or off‐premise outlets have a stronger association. This inconsistency may be in part result of methods used to calculate crime. analysis uses routine activity theory spatial access study including type crime Baltimore, MD. Methods The this include from 2016 ( n = 1,204), crimes 2012 51,006), markers social disorganization,...
Eviction affects a substantial share of U.S. children, but its effects on child health are largely unknown. Our objectives were to examine how eviction relates 1) children's and sociodemographic characteristics at birth, 2) neighborhood poverty food security age 5, 3) obesity in later childhood adolescence. We analyzed data from the Fragile Families Child Wellbeing Study, longitudinal cohort children born 20 large cities. Children who lived rental housing with known histories measured...
OBJECTIVES To measure associations between residential moves because of unaffordable housing costs and disruptions in access to the Supplemental Nutrition Assistance Program; Special Program for Women, Infants, Children; Medicaid a health care-based sample families with young children. METHODS We used cross-sectional survey data on social safety net-eligible caregivers children recruited into Children’s HealthWatch study from emergency departments primary care clinics Baltimore Philadelphia...
Summary Identifying aberrant T lymphocytes in peripheral blood is essential for diagnosing Sezary syndrome (SS) and a prognostic indicator mycosis fungoides (MF). Flow cytometry using T‐cell receptor constant beta‐1 chain (TRBC1)‐targeting antibody provides refined approach detecting clonality. We evaluated the performance of TRBC1 assay (TRBC1‐aa) 164 patients, compared to standard flow methods assessing aberrancy, demonstrating 92.3% sensitivity 83.5% specificity. TRBC1‐aa accurately...
Spatial distribution of repeat and singly occurring gonorrhea in Baltimore, Maryland, was examined to identify clusters core transmitters. Gonorrhea reported between 2001 2002 geocoded mapped. Those with more than one infection separated by 14 days during the 2-year period were considered repeaters. Other cases treated as isolated events. Six definitions transmission census tracts highest quintiles 1) for 2001, 2) 2002, 3) rates 4) 5) counts repeaters over period, 6) proportion total that Of...