A5101838366- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Lung Cancer Treatments and Mutations
- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- HER2/EGFR in Cancer Research
- Wireless Body Area Networks
- Growth Hormone and Insulin-like Growth Factors
- Atrial Fibrillation Management and Outcomes
- Cancer Treatment and Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Cardiac Structural Anomalies and Repair
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Advanced Battery Technologies Research
- Neonatal and fetal brain pathology
- Neuroscience and Neural Engineering
- Glioma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Metabolism, Diabetes, and Cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
Duke University
2025
Dumfries and Galloway Royal Infirmary
2025
Harefield Hospital
2021-2024
Guy's and St Thomas' NHS Foundation Trust
2021-2024
Auckland City Hospital
2022-2024
Royal Brompton & Harefield NHS Foundation Trust
2022-2023
Diamond Materials (United States)
2020-2022
Royal Brompton Hospital
2021-2022
Royal Victoria Hospital
2022
University of Ulster
2022
Background: The IGF-1 receptor (IGF-1R) has been implicated in the promotion of tumorigenesis, metastasis and resistance to cancer therapies. Therefore, this become a major focus for development anticancer agents. Results: Our lead optimization efforts that blended structure-based design empirical medicinal chemistry led discovery OSI-906, novel small-molecule dual IGF-1R/insulin (IR) kinase inhibitor. OSI-906 potently selectively inhibits autophosphorylation both human IGF-1R IR, displays...
Insulin-like growth factor-I receptor (IGF-IR) and its ligands, IGF-I IGF-II, are up-regulated in a variety of human cancers. In tumors, such as colorectal, non-small cell lung, ovarian, pediatric cancers, which may drive their own survival through autocrine IGF-II expression, the role IGF-IR is especially critical. Here, we present novel small-molecule kinase inhibitor, cis-3-[3-(4-methyl-piperazin-l-yl)-cyclobutyl]-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-8-ylamine (PQIP),...
Background: Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and these relationships affected by birth asphyxia or vary anatomic region. Methods: Neonates cooled HIE received near-infrared spectroscopy monitoring to identify the mean arterial blood pressure optimized autoregulatory function (MAPOPT). Blood deviation from...
Abstract Background Leadless pacemakers (LPs) may mitigate the risk of lead failure and pocket infection related to conventional transvenous pacemakers. Atrial LPs are currently being investigated. However, optimal safest implant site is not known. Objectives We aimed evaluate right atrial (RA) anatomy adjacent structures using complementary analytic models [gross anatomy, cardiac magnetic resonance imaging (MRI), computer simulation], identify location an LP human. Methods results Wall...
Abstract Background Pulse field ablation (PFA) is a novel catheter technology with potential safety benefits due to its tissue selectivity. It has the directly damage or interact functionality of cardiac implantable electronic devices (CIEDs) in form electromagnetic interference (EMI). The aim our study was assess impact PFA on CIEDs. Methods lesions (45 per CIED) were applied from Farapulse system CIEDs (< 5 cm lead tip and < 15 generator). All checked before after application for...
OSI-930 is a novel inhibitor of the receptor tyrosine kinases Kit and kinase insert domain (KDR), which currently being evaluated in clinical studies. selectively inhibits KDR with similar potency intact cells also these targets vivo following oral dosing. We have investigated relationships between observed cell-based assays vitro, plasma exposure levels achieved dosing, time course target inhibition vivo, antitumor activity tumor xenograft models. In mutant Kit-expressing HMC-1 model,...
Conduction system pacing (CSP), consisting of His bundle (HBP) or left branch area (LBBAP) is a rapidly developing field. These techniques result in single lead ventricular resynchronisation. Understanding the associated learning curve two an important consideration for new implanters/implanting centres.We conducted review first 30 cases both HBP and LBBAP at The Royal Brompton Hospital. procedural duration fluoroscopy time were used as surrogates each technique.Patient characteristics...
This report describes a 7-week-old infant with incomplete and atypical Kawasaki disease, an acute vasculitis that predominantly affects infants children. The patient was refractory to 2 doses of intravenous immunoglobulin high-dose methylprednisolone. He became afebrile only after infliximab. His prolonged, recalcitrant course complicated by the development peripheral gangrene giant coronary artery aneurysms. Infants disease are prone treatment failure at risk for In such patients, we...
Epithelial to mesenchymal transition (EMT) plays a dual role in tumor progression. It enhances metastasis of cells by increasing invasive capacity and promoting survival, it decreases cell sensitivity epithelial cell-targeting agents such as growth factor receptor kinase inhibitors. In order study EMT cells, we have characterized 3 new models ligand-driven EMT: the CFPAC1 pancreatic model H358 H1650 lung models. We identified diverse set ligands that drives these Hepatocyte oncostatin M...
3086 Background: BDTX-189 is an orally available, ATP-competitive and irreversible inhibitor directed against families of allosteric HER2 EGFR oncogenic mutations. In preclinical studies achieved potent inhibition 48 EGFR/HER2 exon 20 insertion mutant variants with selectivity versus wild-type (WT) demonstrated tumor growth regression in vivo. The primary objective the Ph 1 portion this trial (NCT04209465) to determine RP2D schedule monotherapy pts advanced solid tumors. Methods: Eligibility...
Abstract Aims Left bundle branch area pacing (LBBAP) has been shown to be effective and safe. Limited data are available on LBBAP in the congenital heart disease (CHD) population. This study aims describe feasibility safety of CHD patients compared with non-CHD patients. Methods results is a single-centre, non-randomized observational recruiting consecutive bradycardia indication. Demographic data, ECGs, imaging, procedural including lead parameters were recorded. A total 39 included: group...
Abstract The molecular landscape of EGFR mutated NSCLC has evolved over time in response to changing treatment practices with inhibitors and through the expanding use NGS. With replacement first-generation reversible tyrosine kinase (TKIs) by third generation covalent TKI osimertinib as front-line therapy for patients expressing classical mutations, acquired resistance mutations have shifted near disappearance EGFR-T790M emergence growing incidence EGFR-C797S. Our understanding mutation also...
Abstract Introduction ICD lead failure is a potential source of significant morbidity and mortality. This study investigates the survival rates Sprint Quattro, Endotak Reliance, Linox leads. Methods results A retrospective cohort all patients with an implanted between January 2007 December 2012 from Wellington Hospital region, New Zealand, tertiary referral center. Lead patient details were established by review clinical notes PaceArt Optima database. We analyzed total 287 implants using...