A5100652516- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Medical Image Segmentation Techniques
- Cardiovascular Function and Risk Factors
- AI in cancer detection
- Neurological disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Elasticity and Material Modeling
- Cardiac Structural Anomalies and Repair
- Ultrasound Imaging and Elastography
- Statistical Methods and Inference
- Probabilistic and Robust Engineering Design
- Cardiac Valve Diseases and Treatments
- Wireless Power Transfer Systems
- Ion channel regulation and function
- Medical Imaging Techniques and Applications
- ECG Monitoring and Analysis
- Central Venous Catheters and Hemodialysis
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Medical Imaging and Analysis
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
Lung Institute
2025
King's College London
2016-2025
Imperial College London
2024-2025
St Thomas' Hospital
2013-2021
University of California, San Francisco
2021
McGill University
2019-2020
Stanford Medicine
2019
University of Toronto
2017-2018
University Health Network
2017
Guy's and St Thomas' NHS Foundation Trust
2015
His-bundle pacing (HBP) and left bundle (LBP) are emerging as novel delivery methods for cardiac resynchronization therapy (CRT) in heart failure patients with branch block (LBBB). HBP LBP have never been compared to biventricular endocardial (BiV-endo) pacing. Furthermore, there indications of negative effects on right ventricular (RV) activation times (ATs), but these not quantified.The purpose this study was compare changes induced by HBP, LBP, (LV) septal pacing, BiV-endo, epicardial...
Personalised medicine is based on the principle that each body unique and will respond to therapies differently. In cardiology, characterising patient specific cardiovascular properties would help in personalising care. One promising approach for these relies performing computational analysis of multimodal imaging data. An interactive cardiac environment, which can seamlessly render, manipulate, derive calculations, otherwise prototype research activities, therefore sought-after.We developed...
Abstract Background Leadless pacemakers (LPs) may mitigate the risk of lead failure and pocket infection related to conventional transvenous pacemakers. Atrial LPs are currently being investigated. However, optimal safest implant site is not known. Objectives We aimed evaluate right atrial (RA) anatomy adjacent structures using complementary analytic models [gross anatomy, cardiac magnetic resonance imaging (MRI), computer simulation], identify location an LP human. Methods results Wall...
Computational cardiac physiology has great potential to improve the management of cardiovascular diseases. One main bottlenecks in this field is customization computational model anatomical and physiological status patient. We present a fully automatic service for geometrical personalization ventricular meshes with high-order interpolation from segmented images. The method versatile (able work different species disease conditions) robust (fully results fulfilling accuracy quality...
Cardiac resynchronization therapy (CRT) delivered via left ventricular (LV) endocardial pacing (ENDO-CRT) is associated with improved acute hemodynamic response compared LV epicardial (EPI-CRT). The role of cardiac anatomy and physiology in this remains controversial. We used computational electrophysiological models to quantify the geometry, tissue anisotropy, presence fast conduction on myocardial activation during ENDO-CRT EPI-CRT.Cardiac was simulated using monodomain excitation model...
Reduced left atrial (LA) mechanical function associates with myopathy and adverse clinical endpoints in fibrillation (AF) patients; however, conventional 2D imaging modalities are limited by foreshortening sub-optimally capture 3D LA motion. We set out to test the hypothesis that motion features from 4D (3D + time) retrospective gated computed tomography (RGCT) associate AF phenotypes predict recurrence patients undergoing catheter ablation. Sixty-nine (60.8 ± 12.2 years, 39% female, 30%...
The steepness of the action potential duration (APD) restitution curve and local tissue refractoriness are both thought to play important roles in arrhythmogenesis. Despite this, there has been little recognition apparent association between steady-state APD slope curve. objective this study was test hypothesis that is determined by examine relationship slope, susceptibility VF.Experiments were conducted isolated hearts ventricular myocytes from adult guinea pigs rabbits. Restitution curves...
Cardiac Resynchronization Therapy (CRT) is one of the few effective treatments for heart failure patients with ventricular dyssynchrony. The pacing location left ventricle indicated as a determinant CRT outcome. Patient specific computational models allow activation pattern following implant to be predicted and this may used optimize lead placement. In study, effects heterogeneous cardiac substrate (scar, fast endocardial conduction, slow septal functional block) on accurately predicting...
Cardiac anatomy and function adapt in response to chronic cardiac resynchronization therapy (CRT). The effects of these changes on the optimal left ventricle (LV) lead location timing delay settings have yet be fully explored.
With access to surgical care, >90% of today's infants with congenital heart disease (CHD) will reach adulthood. During childhood, survivors accrue a wealth health care experience and develop strategies for navigating life chronic disease.Seeking learn from this individualized process, we invited adults complex CHD participate in narrative analysis-an established qualitative research method studying how individuals derive meaning their personal stories. Audio recordings 2-4 hour free-form...
Optimal positioning of the left ventricular (LV) lead is an important determinant cardiac resynchronization therapy (CRT) response.
Left bundle branch area pacing (LBBAP) is a novel form of conduction system which can reverse left block and deliver cardiac resynchronization therapy (CRT). The WiSE-CRT delivers leadless endocardial with symptomatic ventricular (LV) remodelling improvements following intervention. We report the technical feasibility delivering LBBAP using system.In Case 1, 57-year-old male ischaemic cardiomyopathy complete heart underwent implantation system, retrograde transaortic approach, after failed...
Cardiac resynchronization therapy (CRT) is an important treatment for heart failure. Low female enrollment in clinical trials means that current CRT guidelines may be biased toward males. However, females have higher response rates at lower QRS duration (QRSd) thresholds. Sex differences the left ventricle (LV) size could provide explanation improved QRSd. We aimed to test if sex QRSd thresholds are explained by LV and hence predict sex-specific CRT. investigated effect difference has on...
Surgery remains the only known treatment option for rectal prolapse. Although over 100 abdominal and perineal procedures are available, there is no consensus as to which intervention best suited an individual. This retrospective cohort study describes patient- disease-related factors involved in making surgical recommendations around prolapse a single surgeon experience.91 consecutive patients ≥18 years old diagnosed with external and/or high-grade internal were assessed prospectively...
Abstract Introduction Atrial remodelling (AR) is the persistent change in atrial structure and/or function and contributes to initiation, maintenance progression of fibrillation (AF) a reciprocal self‐perpetuating relationship. Left (LA) size, geometry, fibrosis, wall thickness (LAWT) ejection fraction (LAEF) have all been shown vary with pathological remodelling. The association these global markers each other for differentiating structural phenotypes AF not well investigated. Method...