A5085599943- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
- Surgical Simulation and Training
- Elasticity and Material Modeling
- Cardiomyopathy and Myosin Studies
- Augmented Reality Applications
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Anatomy and Medical Technology
- Medical Image Segmentation Techniques
- Cardiac Structural Anomalies and Repair
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Fetal and Pediatric Neurological Disorders
- Coronary Interventions and Diagnostics
King's College London
2016-2025
St Thomas' Hospital
2014-2024
King's College Hospital
2011-2024
King's College School
2013-2024
King's College - North Carolina
2019-2024
University of Oxford
2010-2023
Twin Cities Orthopedics
2022
University of Minnesota
2022
John Radcliffe Hospital
2012-2020
Kings Health Partners
2012-2018
Providing therapies tailored to each patient is the vision of precision medicine, enabled by increasing ability capture extensive data about individual patients. In this position paper, we argue that second enabling pillar towards power computers and algorithms learn, reason, build 'digital twin' a patient. Computational models are boosting capacity draw diagnosis prognosis, future treatments will be not only current health status data, but also an accurate projection pathways restore model...
Preterm birth leads to an early switch from fetal postnatal circulation before completion of left ventricular in utero development. In animal studies, this results adversely remodeled ventricle. We determined whether preterm is associated with a distinct structure and function humans. A total 234 individuals 20 39 years age underwent cardiovascular magnetic resonance. One hundred two had been followed prospectively since (gestational age=30.3±2.5 week; weight=1.3±0.3 kg), 132 were born at...
Cardiac resynchronization therapy (CRT) has emerged as one of the few effective and safe treatments for heart failure. However, identifying patients that will benefit from CRT remains controversial. The dependence efficacy on organ cellular scale mechanisms was investigated in a patient-specific computer model to identify novel patient selection criteria. A biophysically based coupled electromechanics been developed which links sub-cellular regulate cardiac function whole observed clinically...
Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later infants when this during early development. Cardiac ultrasound was performed on 392 (33% at mean gestation 34±2 weeks). Scans were fetal development 137, birth 3 months of postnatal age 200, both 55. morphology function quantified computational models created to identify geometric changes. At birth, offspring had volume relative body size with more...
The purpose of this study was to establish whether an artificially intelligent (AI) system can be developed automate stress echocardiography analysis and support clinician interpretation.Coronary artery disease is the leading global cause mortality morbidity remains one most commonly used diagnostic imaging tests.An automated image processing pipeline extract novel geometric kinematic features from echocardiograms collected as part a large, United Kingdom-based prospective, multicenter,...
Deep learning can bring time savings and increased reproducibility to medical image analysis. However, acquiring training data is challenging due the time-intensive nature of labeling high inter-observer variability in annotations. Rather than images, this work we propose an alternative pipeline where images are generated from existing high-quality annotations using generative adversarial networks (GANs). Annotations derived automatically previously built anatomical models transformed into...
An unresolved issue in patients with diastolic dysfunction is that the estimation of myocardial stiffness cannot be decoupled from residual active tension (AT) because impaired ventricular relaxation during diastole. To address this problem, paper presents a method for estimating mechanical parameters left ventricle (LV) cine and tagged MRI measurements LV cavity pressure recordings, separating passive constitutive properties AT. Dynamic C1-continuous meshes are automatically built anatomy...
BACKGROUND AND OBJECTIVES: Preterm birth relates to long-term alterations in cardiac morphology and function. Understanding whether preterm postnatal life is a tractable period of cardiovascular development that can be positively altered by nutrition relevant outcomes. We hypothesized being fed human breast milk during early beneficial structure function preterm-born individuals compared with infant formulas. METHODS: A total 926 infants originally took part randomized controlled trial...
Background— Transvalvular peak pressure drops are routinely assessed noninvasively by echocardiography using the Bernoulli principle. However, principle relies on several approximations that may not be appropriate, including majority of drop is because spatial acceleration blood flow, and ejection jet a single streamline (single velocity value). Methods Results— We accuracy to estimate at aortic valve 3-dimensional cardiovascular magnetic resonance flow data in 32 subjects. Reference were...
Cardiovascular magnetic resonance (CMR) offers quantification of phasic atrial functions based on volumetric assessment and more recently, CMR feature tracking (CMR-FT) quantitative strain rate (SR) deformation imaging. Inter-study reproducibility is a key requirement for longitudinal studies but has not been defined CMR-based left (LA) right (RA) dynamics. Long-axis 2- 4-chamber cine images were acquired at 9:00 (Exam A), 9:30 B) 14:00 C) in 16 healthy volunteers. LA RA reservoir, conduit...
The objective of this study is to assess the dynamic alterations myocardial microstructure and strain between diastole systole in patients with dilated cardiomyopathy relative healthy controls using magnetic resonance diffusion tensor imaging, tagging, biomechanical modeling.Dual heart-phase imaging was successfully performed 9 controls. Tagging data were acquired for correction cardiac motion analysis. Mean diffusivity, fractional anisotropy, myocyte aggregate orientations compared both...
The left atrium (LA) can change in size and shape due to atrial fibrillation (AF)-induced remodeling. These alterations be linked poorer outcomes of AF ablation. In this study, we propose a novel comprehensive computational analysis LA anatomy identify what features optimally predict post-ablation recurrence. To end, construct smooth 3D geometrical models from the segmentation blood pool captured pre-procedural MR images. We first apply methodology characterize 144 patients build statistical...
Cardiac anatomy plays a crucial role in determining cardiac function. However, there is poor understanding of how specific and localised anatomical changes affect different functional outputs. In this work, we test the hypothesis that statistical shape model (SSM), modes are most relevant for describing also important output electromechanics simulations. We made patient-specific four-chamber heart meshes ( n = 20) from CT images asymptomatic subjects created SSM 19 cases. Nine captured 90%...
Left ventricular ejection fraction (LVEF) and end-systolic volume (ESV) remain the main imaging biomarkers for post-acute myocardial infarction (AMI) risk stratification. However, they are limited to global systolic function fail capture functional anatomical regional abnormalities, hindering their performance in stratification.This study aimed identify novel 3-dimensional (3D) (ES) shape contraction descriptors toward risk-related features superior prognosis AMI.A multicenter cohort of AMI...
Abstract Traditionally, congestive heart failure (HF) was phenotyped by echocardiography or other imaging techniques according to left ventricular (LV) ejection fraction (LVEF). The more recent echocardiographic modality speckle tracking strain is complementary LVEF, as it sensitive diagnose mild systolic dysfunction. Furthermore, when LV dysfunction associated with a small, hypertrophic ventricle, EF often normal supernormal, whereas global longitudinal can reveal reduced contractility. In...
Preeclampsia is a multiorgan disease of pregnancy that has short- and long-term implications for the woman fetus, whose immediate impact poorly understood. We present novel approach to magnetic resonance imaging (MRI) investigation preeclampsia, with acquisition maternal cardiac, placental, fetal brain anatomic functional imaging.
The evaluation of cardiovascular velocities, their changes through the cardiac cycle and consequent pressure gradients has capacity to improve understanding subject-specific blood flow in relation adjacent soft tissue movements. Magnetic resonance time-resolved 3D phase contrast velocity acquisitions (4D flow) represent an emerging technology capable measuring cyclic large scale, multi-directional, flow. A subsequent differences enclosed vascular compartments is a further step which...