A5059809327- Digital Radiography and Breast Imaging
- Global Cancer Incidence and Screening
- AI in cancer detection
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Infrared Thermography in Medicine
- Colorectal Cancer Screening and Detection
- Bioinformatics and Genomic Networks
- Advanced MRI Techniques and Applications
- Distributed and Parallel Computing Systems
- Health, Environment, Cognitive Aging
- Nutritional Studies and Diet
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Ultrasound Imaging and Elastography
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Cervical Cancer and HPV Research
- Scientific Computing and Data Management
- Medical Image Segmentation Techniques
Addenbrooke's Hospital
2008-2021
University of Cambridge
2006-2021
University of Otago
2020
Cambridge University Hospitals NHS Foundation Trust
2010-2015
Harvard University Press
2014
Queen Mary University of London
2011-2014
University of Manchester
2011-2012
The Royal Free Hospital
2012
University College London
2012
Institute of Cancer Research
2000-2012
Mammographic breast density is a strong risk factor for cancer. Tamoxifen, which reduces the of cancer in women at high risk, also mammographic density. However, it not known if tamoxifen-induced reductions can be used to identify who will benefit most from prophylactic treatment with this drug. We conducted nested case–control study within first International Breast Cancer Intervention Study, randomized prevention trial tamoxifen vs placebo. was assessed visually and expressed as percentage...
Although mammographic breast density is associated with the risk of cancer and influenced by hormone levels, effects tamoxifen on in healthy women whether tamoxifen-induced changes are unclear. We investigated an increased at baseline during 54 months treatment.Mammograms were reviewed from 818 cancer-free (388 group 430 placebo group) high for cancer, International Breast Cancer Intervention Study I, a trial prevention. measurements, treatment, obtained 12- to 18-month intervals....
Abstract The aim of this study is to determine breast cancer risk at mammographic screening episodes and integrate standard factors with density genetic data assess changing the interval based on offer women high preventive strategies. We report our experience assessing within U.K. National Health Service Breast Screening Program using results from first 10,000 entered into "Predicting Risk Of Cancer At Screening" study. 28,849 attending for fifteen sites in Manchester (35%) consented entry...
Abstract Background: Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little known about the biologic mechanisms underlying association between mammographic risk. We examined whether common low-penetrance susceptibility variants contribute to interindividual differences in measures. Methods: established an international consortium (DENSNP) 19 studies from 10 countries, comprising 16,895 Caucasian women, conduct pooled...
High mammographic density is associated with both risk of cancers being missed at mammography, and increased developing breast cancer. Stratification cancer prevention screening requires measures predictive This study compares five to determine the association subsequent diagnosis presence screening.
Isoflavones are hypothesized to protect against breast cancer, but it is not clear whether they act as oestrogens or anti-oestrogens in tissue. Our aim was determine the effects of taking a red clover-derived isoflavone supplement daily for 1 year on mammographic density. Effects oestradiol, follicle-stimulating hormone (FSH), luteinizing (LH), lymphocyte tyrosine kinase activity and menopausal symptoms were also assessed. A total 205 women (age range 49–65 years) with Wolfe P2 DY patterns...
<h3>Abstract</h3> <b>Objective</b>: To compare mammography reading by one radiologist with independent two radiologists. <b>Design</b>: An observational non-randomised trial at St Margaret9s Hospital, Epping. <b>Subjects</b>: 33734 consecutive attenders for breast screening in the main and a sample of 132 assessment who provided data on private costs. <b>Interventions</b>: Three reporting policies were compared: single reading, consensus double non-consensus reading. <b>Main outcome...
Contrast enhanced magnetic resonance imaging (CE MRI) is the most sensitive tool for screening women who are at high familial risk of breast cancer. Our aim in this study was to assess cost-effectiveness X-ray mammography (XRM), CE MRI or both strategies combined. In total, 649 were enrolled MARIBS and screened with resulting 1881 screens 1–7 individual annual events. Women aged 35–49 years cancer, either because they have a strong family history cancer tested carriers BRCA1, BRCA2 TP53...
Abstract High breast density as measured on mammograms is a strong risk factor for cancer in the general population, but its effect carriers of germline BRCA1 and BRCA2 mutations unclear. We obtained from 206 female or mutations, 96 whom were subsequently diagnosed with 136 relatives who themselves noncarriers. compared mammographic densities affected (cases) unaffected (controls), mutation noncarriers, using computer-assisted method measurement visual assessment by two observers. Analyses...
Abstract Purpose: Magnetic resonance imaging (MRI) screening enables early detection of breast cancers in women with an inherited predisposition. Interval occurred a BRCA1 mutation, possibly due to fast tumor growth. We investigated the effect or BRCA2 mutation and age on growth rate cancers, as this may influence optimal frequency. Experimental Design: reviewed invasive from United Kingdom, Dutch, Canadian MRI trials for at hereditary risk, measuring size diagnosis preceding and/or...
Abstract Introduction Mammographic density (MD) is one of the strongest risk factors for breast cancer. It not clear whether this association best expressed in terms absolute dense area or percentage (PDA). Methods We measured MD, including nondense (here a surrogate weight), mediolateral oblique (MLO) mammogram using computer-assisted thresholding technique 634 cases and 1,880 age-matched controls from Cambridge Norwich Breast Screening programs. Conditional logistic regression was used to...
It is recommended that BRCA1/2 mutation carriers undergo breast cancer screening using MRI because of their very high risk and the sensitivity in detecting invasive cancers. Clinical observations suggest important differences natural history between cancers due to mutations BRCA1 BRCA2, potentially requiring different guidelines.
Abstract Introduction Mammographic density is well-established as a risk factor for breast cancer, however, adjustment age and body mass index (BMI) vital to its clinical interpretation when assessing individual risk. In this paper we develop model adjust mammographic BMI show how adjusted measure might be used with existing prediction models identify high-risk women more precisely. Methods We explored the association between age, BMI, visually assessed percent dense area cancer in nested...
PURPOSE: To prospectively determine sensitivity and specificity of breast magnetic resonance (MR) imaging in a screening symptomatic population by using independent double reading, with histologic or cytologic results minimum 18-month follow-up as the standard. MATERIALS AND METHODS: Informed consent ethical approval were obtained. Reader performance was analyzed 44 radiologists at 18 centers from 1541 examinations, including 1441 examinations 638 high-risk women aged 24–51 years (mean, 40.5...
Objectives To assess the effects of mammographic parenchymal patterns on risk breast cancer detected at first screen, second and in interval between these two screens. Settings A nested case-control study within a screening cohort East Anglia was designed. The group comprised 502 patients with prevalence round, 198 cancer, 175 incidence screen. These were matched 2601 controls. Methods tissue assessed according to Wolfe's classification. Statistical analysis by conditional logistic...
How Predictive Is Breast Arterial Calcification of Cardiovascular Disease and Risk Factors When Found at Screening Mammography?Masako Kataoka1, Ruth Warren2, Robert Luben3, Joanna Camus3, Erika Denton4, Elvis Sala1, Nicholas Day3 Kay-Tee Khaw5Audio Available | Share
Contrast-enhanced (CE) MRI was used to monitor breast cancer response neoadjuvant chemotherapy. Patients underwent CE before and after therapy, together with conventional assessment methods (CAM). carried out at 1.5 T in the coronal plain 3D sequences bolus injection. An expert panel determined chemotherapy using both CAM. Histopathological surgical specimen then determine sensitivity specificity of In total, 67 patients 69 cancers were studied (mean age 46 years). Tumour characteristics...