A5041816438- Digital Radiography and Breast Imaging
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Breast Implant and Reconstruction
- AI in cancer detection
- BRCA gene mutations in cancer
- Reconstructive Surgery and Microvascular Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health, Environment, Cognitive Aging
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Body Contouring and Surgery
- Mesenchymal stem cell research
- Breast Lesions and Carcinomas
- Pregnancy and preeclampsia studies
- Neurological Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition, Genetics, and Disease
- Diversity and Career in Medicine
- Health, psychology, and well-being
- Stroke Rehabilitation and Recovery
- Gene expression and cancer classification
University College London
2013-2025
Stony Brook University Hospital
2025
Royal Free London NHS Foundation Trust
2020-2025
Stony Brook University
2025
Dr. D.Y. Patil Vidyapeeth, Pune
2025
Regional Cancer Center, Thiruvananthapuram
2023-2024
The Royal Free Hospital
2012-2023
NIMS University
2022-2023
The Princess Grace Hospital
2023
Creative Commons
2023
Self-monitoring of blood pressure with self-titration antihypertensives (self-management) results in lower patients hypertension, but there are no data about high-risk groups.To determine the effect self-monitoring antihypertensive medication compared usual care on systolic among cardiovascular disease, diabetes, or chronic kidney disease.A primary care, unblinded, randomized clinical trial involving 552 who were aged at least 35 years a history stroke, coronary heart disease and baseline...
Abstract Background: Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little known about the biologic mechanisms underlying association between mammographic risk. We examined whether common low-penetrance susceptibility variants contribute to interindividual differences in measures. Methods: established an international consortium (DENSNP) 19 studies from 10 countries, comprising 16,895 Caucasian women, conduct pooled...
<h3>Abstract</h3> <h3>Objective</h3> To evaluate the effectiveness of telephone health coaching delivered by a nurse to support self management in primary care population with mild symptoms chronic obstructive pulmonary disease (COPD). <h3>Design</h3> Multicentre randomised controlled trial. <h3>Setting</h3> 71 general practices four areas England. <h3>Participants</h3> 577 patients Medical Research Council dyspnoea scale scores 1 or 2, recruited from COPD registers spirometry confirmed...
Recent advances in neoadjuvant systemic therapy (NST) have significantly improved pathologic complete response rates early breast cancer, challenging the role of axillary lymph node dissection nose-positive patients. Targeted (TAD) integrates marked biopsy (MLNB) and tracer-guided sentinel (SLNB). The introduction new wire-free localisation markers (LMs) has streamlined TAD increased its adoption. primary endpoints include successful retrieval LMs. secondary pathological (pCR), SLNB, MLNB...
Background/Objectives: Polygenic risk scores (PRSs) have been extensively studied and are increasingly applied in healthcare. One of the most developed areas is predictive medicine for breast cancer, but there no wider consensus on indications clinical use PRSs cancer. This current guidance endeavours to articulate scientific evidence underpinning utility stratifying cancer risk, with a particular emphasis application. Methods: has prepared by group experts who active PRS research...
Abstract Background An increasing number of older people are living with chronic kidney disease (CKD). Many have complex healthcare needs and at risk deteriorating health functional status, which can adversely affect their quality life. Comprehensive geriatric assessment (CGA) is an effective intervention to improve survival independence people, but its clinical utility cost-effectiveness in frail CKD unknown. Methods The GOAL Trial a pragmatic, multi-centre, open-label, superiority, cluster...
Introduction: Ischemic stroke is highly heterogeneous, with patient-to-patient differences in infarct location, severity, and degree of reperfusion, among other factors. Incorporating this variability preclinical models useful to more comprehensively recapitulate the patient population. Prior studies employ Longa (complete reperfusion) or Koizumi (chronic hyporeperfusion) murine interchangeably over a range ischemic durations. These represent distinct phenotypes, but unique features each...
Introduction: Despite efforts to improve stroke outcomes in patients, a translational gap exists between preclinical and clinical studies. Due this gap, the Stroke Preclinical Assessment Network has incorporated corner test (CoT) for behavioral outcome as primary measure evaluating whether treatment is successful or not. Standard analysis CoT uses laterality index detect if there mouse turning preference on scale from -1 1. We sought determine deep learning approach using “DeepLabCut” could...
A BSTRACT Background: Pregnancy-induced hypertension (PIH) negatively affects the antepartum quality of life, necessitating complementary interventions to improve maternal well-being. This study evaluates effectiveness guided imagery therapy in enhancing life among women with PIH. Objectives: To assess impact on diagnosed Methods: quasi-experimental was conducted 60 participants assigned either a group (n=30) receiving or control standard care. Quality measured using validated scale before...
Abstract Percent mammographic breast density (PMD) is a strong heritable risk factor for cancer. However, the pathways through which this mediated are still unclear. To explore whether PMD and cancer have shared genetic basis, we identified variants most strongly associated with in published meta-analysis of five genome-wide association studies (GWAS) used these to construct scores 3,628 cases 5,190 controls from UK2 GWAS The signed per-allele effect estimates single-nucleotide polymorphisms...
The prevalence of diagnosed chronic obstructive pulmonary disease (COPD) in the UK is 1.8%, although it estimated that this represents less than half total population as much remains undiagnosed. Case finding initiatives primary care will identify people with mild and symptoms. majority self-management trials have identified patients from secondary clinics or following a hospital admission for exacerbation their condition. This trial recruit symptoms COPD use telephone health coaching to...
Recent advances in systemic treatment for breast cancer have been underpinned by recognising and exploiting subtype-specific vulnerabilities to achieve higher rates of pathologic complete response (pCR) after neo-adjuvant therapy (NAST). This down-staging disease has permitted safe surgical de-escalation patients who respond well. Triple-negative (TNBC) or HER2-positive is most likely radiological (rCR) pCR NAST. Hence, selected patients, particularly those are clinically node-negative (cN0)...
Mammographic breast density and endogenous sex-hormone levels are both strong risk factors for cancer. This study investigated whether there is evidence a shared genetic basis between these factors.Using data on 1,286 women from 617 families, we estimated the heritabilities of serum estradiol, testosterone, binding globulin (SHBG) three measures (dense area, nondense percentage density). We tested associations hormone environmental correlations pairs traits using variance covariance...
Abstract Background Self-monitoring of hypertension with self-titration antihypertensives (self-management) results in lower systolic blood pressure for at least one year. However, few people high risk groups have been evaluated to date and previous work suggests a smaller effect size these groups. This trial therefore aims assess the added value self-management over above usual care. Methods/Design The targets control stroke (TASMIN-SR) will be pragmatic primary care based, unblinded,...