A5054159201- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- demographic modeling and climate adaptation
- Gender, Labor, and Family Dynamics
- Genetic Associations and Epidemiology
- Education Systems and Policy
- Educational Games and Gamification
- Family Dynamics and Relationships
- Statistics Education and Methodologies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child Therapy and Development
- DNA Repair Mechanisms
- Complementary and Alternative Medicine Studies
- Child and Adolescent Psychosocial and Emotional Development
- Experimental Learning in Engineering
- Neurofibromatosis and Schwannoma Cases
- MRI in cancer diagnosis
- Mathematics Education and Programs
- Engineering Education and Curriculum Development
- Cancer Genomics and Diagnostics
- Digital Storytelling and Education
- Reflective Practices in Education
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Cancer survivorship and care
Salford Royal Hospital
2023
University of Manitoba
2022
Victoria University
2021
Dana-Farber Cancer Institute
2019
Tennessee Oncology
2019
Peter MacCallum Cancer Centre
2019
The University of Texas MD Anderson Cancer Center
2019
Seagen (United States)
2019
University of Colorado Cancer Center
2019
University of Colorado Denver
2019
Neurofibromatosis type 1 (NF1) is an autosomal dominant condition affecting around one in 3000 live births. The manifestations of this are extremely variable, even within families, and genetic counselling consequently difficult with regard to prognosis. Individuals NF1 acknowledged be at increased risk malignancy. Several studies have previously attempted quantify risk, but involved relatively small study populations. We present prospective data from 448 individuals a total 5705 years...
Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 BRCA2 has important implications clinical management of people found to carry a mutation. However, genetic is expensive may be associated with adverse psychosocial effects. To provide cost-efficient clinically appropriate counselling service, should targeted at those individuals most likely pathogenic mutations. Several algorithms that predict likelihood carrying or mutation are currently used in practice identify...
Study Type – Diagnostic (validating cohort) Level of Evidence 1b What’s known on the subject? and What does study add? Scientists have found a number genetic factors that increase prostate cancer risk, including heritable mutations in genes BRCA1 BRCA2 . These are not common but can major impact, as mutation increases risk by up to seven‐fold while is thought double men under 65. The IMPACT aims determine whether targeted screening with or would lead earlier diagnosis cancers. This data from...
Abstract We designed and engineered novel intravaginal ring (IVR) medical devices via fused deposition modeling (FDM) three-dimensional (3D) printing for controlled delivery of hydroxychloroquine, IgG, gp120 fragment (encompassing the CD4 binding site), coumarin 6 PLGA-PEG nanoparticles (C6NP). The hydrophilic polyurethanes were utilized to 3D-print reservoir-type IVRs containing a tunable release controlling membrane (RCM) with varying thickness adaptable micro porous structures (by...
Breast cancer has a significant heritable basis, of which ∼60% remains unexplained. Testing for BRCA1/BRCA2 offers useful discrimination breast risk within families, and identification additional susceptibility genes could offer clinical utility.We included 2135 invasive cases recruited via the Ovarian Cancer Susceptibility study, retrospective UK study familial cancer.female, BRCA-negative, white European ethnicity, one of: (i) family history, (ii) bilateral disease, (iii) young age onset...
Abstract A prospective cohort study of 2357 women eligible for participation in the UK National Breast Screening Programme was carried out to evaluate immediate emotional and behavioural effects attending routine mammography. Women completed Hospital Anxiety Depression Scale (HADS) context a survey by their General Practitioner before they knew were receive an invitation attend screening again at some 6 weeks later. In addition, ad hoc Health Questionnaire administered when attended assess...
Objective: To examine aspects of the reliability and validity Reynolds Adolescent Depression Scale (RADS) in measuring depression New Zealand adolescents all major ethnic groups. Method: A sample 9699 randomly selected secondary school students participated Youth2000 Health Wellbeing Survey which included RADS. Data from this survey have been used to assess some RADS context across different Cronbach's alpha, itemtotal score correlations, correlation other questions a factor analysis were...
O bjectives : To determine owner's perception of their pet's quality life during treatment with carboplatin for a variety canine and feline neoplasms. M ethods Owners were contacted via postal questionnaire asked questions regarding chemotherapy in pets pet. R esults Twenty‐eight (59%) owners responded to the questionnaire. Forty‐three percent had not considered before treatment; however, after treatment, 89% supported its use. Sixteen (57%) patients mild severe side effects. Most...
As part of the Magnetic Resonance Imaging for Breast Screening (MARIBS), Study women with a family history breast cancer were assessed psychologically to determine relative psychological impact and acceptability annual screening using magnetic resonance imaging (MRI) conventional X-ray mammography (XRM). Women at baseline (4 weeks before MRI XRM), immediately before, after, both XRM, follow-up (6 after scans). Overall, procedures found be acceptable high levels satisfaction (MRI, 96.3%...
The debate continues regarding the best management for women with low-grade abnormal cervical cytology attending colposcopy. We compared psychosocial outcomes of alternative policies in these women.
In 1994, the UK National Health Service identified as a research priority that magnetic resonance imaging (MRI) should be assessed screening tool for young, pre-menopausal women who are at high genetic risk of developing breast cancer. 1997 national multicentre study was established to compare MRI with X-ray mammography method cancer in this group women. This paper reviews relevant literature and describes rationale led setting up study.
<h3>Background</h3> A novel oncogenetic clinic was established in 2002 at the Royal Marsden NHS Foundation Trust offering advice and specialist follow-up for families with a germline mutation <i>BRCA1</i> or <i>BRCA2</i>. The remit of this multidisciplinary clinic, staffed by individuals both oncology genetics, is to provide individualised screening recommendations, support decision making, risk reducing strategies, cascade testing, an extensive research portfolio. <h3>Methods</h3>...
Single-nucleotide polymorphisms (SNPs) in genes involved DNA repair are good candidates to be tested as phenotypic modifiers for carriers of mutations the high-risk susceptibility BRCA1 and BRCA2. The base excision (BER) pathway could particularly interesting given relation synthetic lethality that exists between one components pathway, PARP1, both In this study, we have evaluated XRCC1 gene participates BER modifier Three common SNPs gene, c.-77C>T (rs3213245) p.Arg280His (rs25489)...
Despite the importance of mathematical skills in quantitative disciplines, high failure rates first- year university mathematics subjects have been observed many parts world. Mathematics support provisions are established tertiary institutions order to assist at- risk students master and pass subjects. However, while a significant amount data is being collected on (e.g. entry scores, backgrounds), their behaviour access services, engagement with online resources) performance assignments,...
The protocol of the national multicentre study Magnetic Resonance Imaging (MRI) as a method screening for breast cancer in women at genetic risk is described. sensitivity and specificity contrast-enhanced MRI will be compared with two-view X-ray mammography comparative trial. Approximately 500 below age 50 high recruited per year 3 years, annual examination continuing up to 5 years. A symptomatic cohort measured initial phase ensure consistent reporting between centres. comprise an...
Choice mechanisms and social networks, including "marriage markets", seem well-suited to be modelled using agent-type simulations.Few real-world empirical examples are available in the public literature, particularly those human populations of size.We reviewed partnership models both micro-simulation agent-based literatures.We then empirically implemented an algorithm derived from two established inter-censal data on first partnerships New Zealand over period 1981-2006.The purpose exercise...
Abstract Objective: Carotid body tumours are rare lesions which familial in 10 per cent of cases. In this paper, we demonstrate the clinical applicability predictive genetic testing for carotid tumours. Methods: We report a case manifesting with multiple tumours, subsequent demonstrated germline mutation could be traced across generations. review diagnosis and management setting, together strategies presently available to screen individuals from susceptible families. Conclusions: The recent...
In Australian universities, mathematics is often an essential core subject for disciplines such as engineering, information technology and science. These first-year subjects may have large enrolments of which a significant number fail the repeat. While interventions to retain students are common, those who failed before repeating overlooked. this paper, we undertook statistical analysis based on demographic performance data six cohorts undertaking university-level subject. We found that pass...
Objective: To examine aspects of the reliability and validity Reynolds Adolescent Depression Scale (RADS) in measuring depression New Zealand adolescents all major ethnic groups.Method: A sample 9699 randomly selected secondary school students participated Youth2000 Health Wellbeing Survey which included RADS. Data from this survey have been used to assess some RADS context across different groups. Cronbach's alpha, itemtotal score correlations, correlation other questions a factor analysis...