A5021654311- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Reconstructive Surgery and Microvascular Techniques
- Breast Cancer Treatment Studies
- Angiogenesis and VEGF in Cancer
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Liver physiology and pathology
- Infectious Aortic and Vascular Conditions
- Breast Implant and Reconstruction
- Vascular Procedures and Complications
- Pluripotent Stem Cells Research
- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- Cancer Genomics and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Cardiac and Coronary Surgery Techniques
- Renal and related cancers
- Anesthesia and Neurotoxicity Research
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Lymphatic System and Diseases
- Pancreatic function and diabetes
- Silk-based biomaterials and applications
O'Brien Institute
2016-2025
The University of Melbourne
2016-2025
Australian Catholic University
2016-2025
St Vincents Institute of Medical Research
2016-2025
St Vincent's Hospital
2015-2024
Erasmus MC
2024
Yale University
2024
The University of Adelaide
2024
Harry Perkins Institute of Medical Research
2024
The University of Western Australia
2024
A major obstacle to 3-dimensional tissue engineering is incorporation of a functional vascular supply support the expanding new tissue. This overcome in an vivo intrinsic vascularization model where arteriovenous loop (AVL) placed noncollapsible space protected by polycarbonate chamber. Vascular development and hypoxia were examined from 3 days 112 casting, morphometric, morphological techniques understand model's growth remodeling parameters for purposes. At fibrin exudate surrounded AVL,...
Here, we describe a porous 3-dimensional collagen scaffold material that supports capillary formation in vitro, and promotes vascularization when implanted vivo. Collagen scaffolds were synthesized from type I bovine have uniform pore size of 80 μm. In seeded with primary human microvascular endothelial cells suspended fibrin gel formed CD31 positive capillary-like structures clear lumens. vivo, after subcutaneous implantation mice, cell-free vascularized by host neovessels, whilst gradual...
In in vivo tissue engineering, many implanted cells die because of hypoxic conditions immediately postimplantation. The aim this study was to determine whether delayed myoblast implantation, at day 4 or 7, improves survival compared with implantation 0 an arterio-venous loop (AB loop) chamber model. adult inbred Sprague-Dawley rats, AB inserted into a plastic (day 0). Group I, 0, two million DiI-labeled (neonatal inbred) myoblasts were around the loop. Groups II and III, created novel cell...
1. A method is described for the preparation of an extract melanophore dispersing hormone 500 times as potent International Standard posterior lobe powder. 2. Evidence recorded suggesting that polypeptide derived from pig glands different obtained ox material.
We have examined the role of nitric oxide (NO) in a model functional angiogenesis which survival skin flap depends entirely on to provide an arterial blood supply maintain tissue viability. The different effects synthase (NOS) inhibitors rat appeared be explained basis their NOS isoform selectivity. Skin was decreased by iNOS‐selective (inducible NOS) inhibitors, S‐methyl‐isothiourea, aminoguanidine and aminoethylthiorea; unaffected non‐selective inhibitor nitro‐imino‐ L ‐ornithine; enhanced...
ABSTRACT Hypoxia and the development remodeling of blood vessels connective tissue in granulation that forms a wound gap following full‐thickness skin incision rat were examined as function time. A 1.5 cm‐long incisional was created groin opposed edges sutured together. Wounds harvested between 3 days 16 weeks hypoxia, percent vascular volume, cell proliferation apoptosis, α‐smooth muscle actin, endothelial growth factor‐A, factor receptor‐2, transforming factor‐β 1 expression then assessed....
Macrophages predominate among the cells that directly interact with biomaterials and are key orchestrators of host-biomaterial interactions. However, macrophage response to synthetic scaffolds in particular has not been well studied. The aim this study was therefore characterise several rat using immunohistological techniques for a panel markers subclass or activation, including ED1 (CD68), ED2 (CD163), CD80, mannose receptor inducible nitric oxide synthase (iNOS). Materials were implanted...
SUMMARY Three regions of the human pituitary, viz. (1) anterior lobe, (2) posterior and (3) intermediate zone (areas 'basophil cell invasion') in lobe have been separately assayed for 'B' corticotrophin four specimens. The gave highest levels both hormones, contained little either, while (of yielded some but significantly high 'B'. It is suggested that may be secreted by δ cells β pituitary.
Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 NOTCH signaling, is essential for angiogenesis. activates PI3K, which phosphorylates PI(4,5)P2 to PI(3,4,5)P3, activating AKT; however, PI3K/AKT does not direct cell specification. We report that hydrolysis by phosphoinositide-5-phosphatase, INPP5K, contributes INPP5K ablation disrupted specification impaired embryonic angiogenesis associated with enhanced DLL4/NOTCH signaling. degraded a pool generated...
Background Inducible nitric oxide synthase (nitric 2, NOS 2) inhibition significantly suppresses chronically ischaemic skin flap survival, possibly because of reduced angiogenesis. Objectives To investigate the effect genetic 2 on cutaneous wound angiogenesis in two vivo murine models. The impact manipulation vascular endothelial growth factor (VEGF)‐A stimulated and fibroblast (FGF)‐2 was also investigated Matrigel® plug assay. Methods (i) Matrigel plugs/incisional wounds: groups 2−/− mice...