John‐Ross D. Clarke

ORCID: 0000-0002-1904-3874
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About
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Research Areas
  • Cardiac Arrhythmias and Treatments
  • Atrial Fibrillation Management and Outcomes
  • Mechanical Circulatory Support Devices
  • Cardiac electrophysiology and arrhythmias
  • Cardiac pacing and defibrillation studies
  • Cardiac Structural Anomalies and Repair
  • Cardiac Imaging and Diagnostics
  • Heart Failure Treatment and Management
  • Cardiac Arrest and Resuscitation
  • Acute Myocardial Infarction Research
  • Cardiac Valve Diseases and Treatments
  • Transplantation: Methods and Outcomes
  • ECG Monitoring and Analysis
  • Pericarditis and Cardiac Tamponade
  • Ultrasound in Clinical Applications
  • Coronary Interventions and Diagnostics
  • Congenital Heart Disease Studies
  • Venous Thromboembolism Diagnosis and Management
  • Infectious Aortic and Vascular Conditions
  • Bartonella species infections research
  • Spinal Dysraphism and Malformations
  • Obstructive Sleep Apnea Research
  • Cannabis and Cannabinoid Research
  • Fetal and Pediatric Neurological Disorders
  • Brain Metastases and Treatment

Harvard University
2021-2024

Beth Israel Deaconess Medical Center
2021-2024

Yale University
2019-2022

Bridgeport Hospital
2018-2021

Yale New Haven Health System
2018-2019

Birmingham Women's Hospital
1998

Birmingham Children's Hospital
1998

Background Racial and ethnic disparities contribute to differences in access outcomes for patients undergoing heart transplantation. We evaluated contemporary transplantation stratified by race ethnicity as well the new 2018 allocation system. Methods Results Adult recipients from 2011 2020 were identified United Network Organ Sharing database into 3 groups: Black, Hispanic, White. analyzed recipient donor characteristics, outcomes. Among 32 353 (25% 9% 66% White), Black Hispanic younger,...

10.1161/jaha.120.021067 article EN cc-by-nc-nd Journal of the American Heart Association 2021-08-25

Abstract Background Leadless pacemakers (LPs) may mitigate the risk of lead failure and pocket infection related to conventional transvenous pacemakers. Atrial LPs are currently being investigated. However, optimal safest implant site is not known. Objectives We aimed evaluate right atrial (RA) anatomy adjacent structures using complementary analytic models [gross anatomy, cardiac magnetic resonance imaging (MRI), computer simulation], identify location an LP human. Methods results Wall...

10.1093/europace/euad235 article EN cc-by EP Europace 2023-07-31

Identification of epilepsy patients with elevated risk for atrial fibrillation (AF) is critical given the heightened morbidity and premature mortality associated this arrhythmia. Epilepsy a worldwide health problem affecting nearly 3.4 million people in United States alone. The potential increased AF not well appreciated, despite recent evidence from national survey 1.4 hospitalizations indicating that most common arrhythmia epilepsy.We analyzed inter-lead heterogeneity P-wave morphology,...

10.1111/epi.17686 article EN Epilepsia 2023-06-17

Abstract Introduction Numerous P‐wave indices have been explored as biomarkers to assess atrial fibrillation (AF) risk and the impact of therapy with variable success. Objective We investigated utility alternans (PWA) track effects pulmonary vein isolation (PVI) predict arrhythmia recurrence. Methods This medical records study included patients who underwent PVI for AF ablation at our institution, along 20 control subjects without or overt cardiovascular disease. PWA was assessed using novel...

10.1111/jce.16291 article EN Journal of Cardiovascular Electrophysiology 2024-05-07

We report the case of a 52-year-old gentleman, admitted to medical intensive care unit with multiple organ system dysfunction due acute severe pancreatitis. He was found have hypocalcemia, bradycardia and an electrocardiogram (EKG) showing ST-segment elevation in infero-lateral leads. The patient treated intravenous calcium gluconate prompt improvement heart rate reversal EKG changes. Subsequent evaluation for myocardial ischemia negative. believe changes mimicking infarction were...

10.1093/omcr/omy103 article EN cc-by-nc Oxford Medical Case Reports 2018-11-21

A 53-year-old woman with end-stage renal impairment on hemodialysis was evaluated for recurrent episodes of Corynebacterium jeikeium bacteremia and endocarditis. Her recurrences occurred despite surgical debridement extended courses culture-directed antimicrobial therapy. The clinical course complicated by the requirement various endovascular prostheses vascular access. To our knowledge this degree relapse guideline medical therapy is rare challenges current practice understanding group infection.

10.1016/j.idcr.2019.e00610 article EN cc-by-nc-nd IDCases 2019-01-01

Importance Patient outcomes in heart failure clinical trials are generally better than those observed real-world settings. This may be related to stricter inclusion and exclusion criteria trials. Objective We study sought characterize the implications of differences between patients a registry receiving left ventricular assist devices (LVADs). Design, setting, participants retrospective cohort included all INTERMACS (the Interagency Registry for Mechanically Assisted Circulatory Support) who...

10.1371/journal.pone.0242928 article EN cc-by PLoS ONE 2020-12-03

Despite changes inthe legality of cannabis use and the increasing prevalence disorder (CUD), there is little data investigating association between CUD inpatient atrial fibrillation (AF) hospitalizations.Using National Inpatient Sample, we identified Atrial Fibrillation hospitalizations with without a codiagnosis using International Classification Diseases diagnosis codes compared demographics, socioeconomics, comorbidities, outcomes, trends cohorts.Between 2008 2018, 5,155,789 admissions...

10.1111/pace.14356 article EN Pacing and Clinical Electrophysiology 2021-09-10

A 61-year-old African–American man presented 1 hour after the onset of left-sided limb weakness and facial numbness. He was taking an ACE inhibitor for hypertension. One year before, he had developed ischaemic left basal ganglia stroke, having 48 hours symptoms. been medically managed with aspirin high-intensity statin only recovered no residual deficit. On this second presentation met criteria administration alteplase (recombinant tissue plasminogen activator, tPA). …

10.1136/practneurol-2018-002112 article EN Practical Neurology 2019-03-05

Most thyrotoxicosis-related arrhythmias are supraventricular in origin. Ventricular arrhythmias, the absence of underlying coronary disease or heart failure, an unusual manifestation thyrotoxicosis. We report a case ventricular fibrillation (VF) patient with Graves' hyperthyroidism who was later revealed to have rare SCN5A mutation associated Brugada syndrome (BrS).

10.1016/j.hrcr.2020.11.010 article EN cc-by-nc-nd HeartRhythm Case Reports 2020-11-20
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