A5089905177- Numerical methods in inverse problems
- Fractional Differential Equations Solutions
- Electromagnetic Scattering and Analysis
- Acute Kidney Injury Research
- Numerical methods in engineering
- Microwave Imaging and Scattering Analysis
- Iterative Methods for Nonlinear Equations
- Growth Hormone and Insulin-like Growth Factors
- PI3K/AKT/mTOR signaling in cancer
- Sperm and Testicular Function
- Dialysis and Renal Disease Management
- Reproductive Biology and Fertility
- Chemotherapy-induced organ toxicity mitigation
- Electromagnetic Simulation and Numerical Methods
- Nonlinear Differential Equations Analysis
- Mesenchymal stem cell research
- Nanoparticle-Based Drug Delivery
- Advanced Mathematical Modeling in Engineering
- Differential Equations and Boundary Problems
- Face and Expression Recognition
- Thermoelastic and Magnetoelastic Phenomena
- Gene expression and cancer classification
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Collaboration in agile enterprises
- Porphyrin Metabolism and Disorders
Heilongjiang University
2014-2024
Liaoning Technical University
2023
Zhengzhou Central Hospital
2021
Second Xiangya Hospital of Central South University
2019-2020
Central South University
2019-2020
Soil and Fertilizer Institute of Hunan Province
2020
Institute of New Materials
2019-2020
Guangdong University of Petrochemical Technology
2013
Renji Hospital
2009
University of Connecticut
2007
Insulin-like growth factor-I receptor (IGF-IR) and its ligands, IGF-I IGF-II, are up-regulated in a variety of human cancers. In tumors, such as colorectal, non-small cell lung, ovarian, pediatric cancers, which may drive their own survival through autocrine IGF-II expression, the role IGF-IR is especially critical. Here, we present novel small-molecule kinase inhibitor, cis-3-[3-(4-methyl-piperazin-l-yl)-cyclobutyl]-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-8-ylamine (PQIP),...
Acute kidney injury (AKI) is one of the common complications sepsis. Heretofore, there no effective treatment for septic AKI. Recent studies have revealed that besides treating hematological malignancies, human umbilical cord blood mononuclear cells (hUCBMNCs) show good therapeutic effects on other diseases. But whether hUCBMNCs can protect against AKI and its underlying mechanism are unknown. The rat model lipopolysaccharide- (LPS-) induced was developed, injection executed to prevent treat...
The objective of this study was to compare the expression Col1a1, Col1a2, and procollagen I in seminiferous tubules immature adult mice characterize cellular pattern germ cells during spermatogenesis order provide necessary groundwork for further functional studies process spermatogenesis. Microarray analysis demonstrated that Col1a1 Col1a2 were abundantly expressed 6-day-old compared with 60-day-old mice, levels mRNA validated using a semi-quantitative RT-PCR assay. Western blot confirmed...
Abstract Acute kidney disease (AKD) is a state between acute injury (AKI) and chronic (CKD), but the prognosis of AKD unclear there are no risk-prediction tools to identify high-risk patients. 2,556 AKI patients were selected from 277,898 inpatients three affiliated hospitals Central South University January 2015 December 2015. The primary point was whether developed AKD. endpoint death or end stage renal (ESRD) 90 days after diagnosis. Multivariable Cox regression used for 90-day mortality...
Abstract Background Clustering is a widely used technique for analysis of gene expression data. Most clustering methods group genes based on the distances, while few according to similarities distributions levels. Furthermore, as biological annotation resources accumulated, an increasing number have been annotated into functional categories. As result, evaluating performance in terms consistency resulting clusters great interest. Results In this paper, we proposed WDCM (Weibull...
Currently, there is no effective method to prevent renal interstitial fibrosis after acute kidney injury (AKI). In this study, we established and screened a new rat model cisplatin-induced AKI. Our results indicated that rats injected with 4 mg/kg cisplatin once week for two weeks firstly administrated 6.5 loading dose of could set up more accurate reflecting AKI progression fibrosis. Then, investigated the effects possible mechanisms human umbilical cord blood mononuclear cells (hUCBMNCs)...
Currently, there is no effective method to prevent renal interstitial fibrosis after acute kidney injury (AKI). In this study, we established and screened a new rat model cisplatin-induced AKI. Our results indicated that rats injected with 4 mg/kg cisplatin once week for two weeks firstly administrated 6.5 loading dose of could set up more accurate reflecting AKI progression fibrosis. Then, investigated the effects possible mechanisms human umbilical cord blood mononuclear cells (hUCBMNCs)...
Contrast-induced acute kidney injury (CI-AKI) is the third common cause of (AKI), which associated with poor short- and long-term outcomes. Currently, effective therapy strategy for CI-AKI remains lacking. Stanniocalcin-1 (STC1) a conserved glycoprotein antiapoptosis anti-inflammatory functions, but role STC1 in controlling unknown. Here, we demonstrated protective contrast-induced cultured renal tubular epithelial cells rat models. Recombinant human (rhSTC1) regulated mitochondrial quality...
Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) are a promising tool to attenuate cisplatin (CP)-induced acute kidney injury (AKI). However, whether the transplantation of human cord blood mononuclear (hCBMNCs) exhibits similar protective effects and their potential underlying mechanisms action remain unclear. The present study aimed determine hUCMSCs hCBMNCs therapies on an established CP-induced rat model explore action. A total 24 Sprague-Dawley rats, selected based body...
The problem of quantifying the effect alfalfa root morphology on stability shallow surface layer slope Haizhou open-pit coal mine and optimal degree in terms reinforcement by system was addressed. In this study, mechanical parameters plain soil root-soil composite samples were measured indoor tests triaxial compression tests, a calculation model for established FLAC3D numerical simulation software to analyze influence maximum displacement relationship with fractal dimension system. applied...
In this paper, we consider a two-dimensional (2D) time-fractional inverse diffusion problem which is severely ill-posed; i.e., the solution (if it exists) does not depend continuously on data. A modified kernel method presented for approximating of problem, and convergence estimates are obtained based both priori choice posteriori regularization parameters. The numerical examples illustrate behavior proposed method.
To investigate whether estrogen stimulates the proliferation of spermatogonia or induces spermatogenesis in cryptorchid mice.Mice were surgically rendered cryptorchid, then treated with different doses 17beta-estradiol (E2) s.c. once a day. Mice killed at sexual maturity (45 days age), and histological analysis immunofluorescence performed. Serum follicle stimulating hormone (FSH), estradiol, testosterone luteinizing (LH) measured.Low E2 had no notable effect on spermatogonia, but higher...
This report describes the investigation of a series 5,7-disubstituted imidazo[5,1-f][1,2,4]triazine inhibitors insulin-like growth factor-1 receptor (IGF-1R) and insulin (IR). Structure-activity relationship exploration optimization leading to identification, characterization, pharmacological activity compound 9b, potent, selective, well-tolerated, orally bioavailable dual inhibitor IGF-1R IR with in vivo efficacy tumor xenograft models, is discussed.
In this paper, we consider a time-fractional inverse diffusion problem, where the data is given at x = 1 and solution sought in interval 0 ≤ < 1.Such problem obtained from classical equation by replacing first-order time derivative Caputo fractional of order α ∈ (0, 1).We show that severely ill-posed further apply modified kernel method to solve it based on frequency domain.The corresponding convergence estimates are provided.Finally, an example constructed feasibility efficiency proposed method.
In this paper, we study the inverse scattering of tapered waves from sound soft surfaces or horizontally polarized electromagnetic perfectly conducting surfaces. By related Fréchet derivative with respect to a given surface solution direct problems, an efficient algorithm is proposed reconstruct parameters unbounded rough set scattered field measurements. Tapered wave introduced realize asymptotic truncation for fractal surface. order improve results reconstruction, multi-angle and...
A filter regularization method is developed to solve a time-fractional inverse advection–dispersion problem, which based on the modified ‘kernel’ idea. Proofs of convergence are given under both priori and posteriori parameter choice rules. Numerical examples presented illustrate effectiveness proposed algorithm.