A5047953251- Advanced biosensing and bioanalysis techniques
- Aquaculture Nutrition and Growth
- Marine Bivalve and Aquaculture Studies
- Clostridium difficile and Clostridium perfringens research
- Aldose Reductase and Taurine
- Gut microbiota and health
- Airway Management and Intubation Techniques
- Genomics and Phylogenetic Studies
- Biosensors and Analytical Detection
- Sarcoma Diagnosis and Treatment
- Advanced Sensor and Energy Harvesting Materials
- Tracheal and airway disorders
- Protein Structure and Dynamics
- Electrochemical Analysis and Applications
- Ferroelectric and Piezoelectric Materials
- Acupuncture Treatment Research Studies
- Microbial Community Ecology and Physiology
- Invertebrate Immune Response Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Dielectric materials and actuators
- Helicobacter pylori-related gastroenterology studies
- Cardiac tumors and thrombi
- Computational Drug Discovery Methods
- Signaling Pathways in Disease
- Electrochemical sensors and biosensors
Dalian Ocean University
2016-2025
University of Alabama at Birmingham
2019-2025
Hainan Normal University
2025
Northwest University
2024
Shanghai Jiao Tong University
2023-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Qingdao National Laboratory for Marine Science and Technology
2024
Yangzhou Polytechnic Institute
2024
Sichuan University
2023-2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2024
Consolidation immunotherapy after completion of chemoradiotherapy has become the standard care for unresectable locally advanced non-small cell lung cancer and can induce potentially severe life-threatening adverse events, including both immune checkpoint inhibitor-related pneumonitis (CIP) radiation (RP), which are very challenging radiologists to diagnose. Differentiating between CIP RP significant implications clinical management such as treatments decision continue or restart...
Exosomes, as promising vehicles, have been widely used in the research of oral drug delivery, but generally low loading efficiency exosomes seriously limits its application and transformation. In this study, we systematically investigated effects methods physicochemical properties (lipophilicity molecular weight) on milk-derived to explore most appropriate conditions. Our finding revealed that was closely related method, lipophilicity, weight exosome/drug proportions. Of note, demonstrated...
Aflatoxin B1 (AFB1) is one of the most hazardous mycotoxins contamination in food and feed products, which leads to hepatocellular carcinoma humans animals. In present study, we isolated characterized an AFB1 degrading bacteria CG1061 from chicken cecum, exhibited 93.7% degradation rate by HPLC. 16S rRNA gene sequence analysis a multiplex PCR experiment demonstrated that was non-pathogenic Escherichia coli. The culture supernatant E. coli showed 61.8% rate, whereas rates produced...
In this paper, a novel fluorescence biosensing strategy based on GR-5 DNAzyme has been developed for the simple, rapid, sensitive and selective detection of lead ions (Pb2+) by using gold nanoparticles (AuNPs) as quencher. Data from dynamic light scattering (DLS) zeta potential measurements demonstrated that functionalized AuNPs were successfully prepared with good dispersion in aqueous solution. The carboxyfluorescein (FAM) labeled was close proximity to signal quenched, when modified...
Abstract Transient gut microbiota alterations have been reported after antibiotic therapy for Helicobacter pylori . However, alteration in the virome H. eradication remains uncertain. Here, we apply metagenomic sequencing to fecal samples of 44 -infected patients at baseline, 6-week ( N = 44), and 6-month 33) treatment. Following eradication, discover contraction diversity, separation community with increased difference, shifting towards a higher proportion core virus. While is altered...
Background: Patients with intracerebral hemorrhage (ICH) are known to have a higher risk of venous thromboembolism (VTE) than patients acute ischemic stroke, but the factors underlying this difference not been clearly identified. We investigated common characteristics admitted for ICH both determine frequency VTE in population and identify development VTE. Methods: This study was single center, retrospective review consecutively between January 2014 May 2019 at an academic tertiary referral...
Several studies have reported that the overexpression of Sirtuin 1 (SIRT1) was associated with poor prognosis in various human cancers. However, little is known regarding prognostic value SIRT1 lung adenocarcinoma. Therefore, aim this study to evaluate role adenocarcinoma patients. Using a tissue microarray, we detected expression by immunohistochemistry tissue, as well corresponding noncancerous tissues (NCTs). A high level observed 74.7% (56/75) patients and 6.7% (5/75) NCTs (P<0.001)....
Proteolysis-targeting chimeras (PROTACs), which can selectively induce the degradation of target proteins, represent an attractive technology in drug discovery. A large number PROTACs have been reported, but due to complicated structural and kinetic characteristics target-PROTAC-E3 ligase ternary interaction process, rational design is still quite challenging. Here, we characterized analyzed mechanism MZ1, a PROTAC that targets bromodomain (BD) extra terminal (BET) protein (Brd2, Brd3, or...
Anaplastic lymphoma kinase (ALK), a tyrosine receptor kinase, has been proven to be associated with the occurrence of numerous malignancies. Although there have already at least 3 generations ALK inhibitors approved by FDA or in clinical trials, various mutations seriously attenuates effectiveness drugs. Unfortunately, most drug resistance mechanisms still remain obscure. Therefore, it is necessary reveal bottom reasons caused mutations. In this work, on basis verifying accuracy 2 main kinds...
The endo-lysosomal pathway is a major barrier for the trans-epithelial transport of nanoparticles (NPs), but escape strategies could facilitate delivery. Based on polarization properties epithelium, different compartments may result in exocytosis fates NPs and further affect delivery efficiency. Therefore, optimizing sites critical Here, commonly used PEG-coated-poly(lactic-co-glycolic acid) (PLGA)-based were fabricated as model (MNPs) intestinal epithelium was chosen polarized epithelium....