A5011424575- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Pediatric Pain Management Techniques
- Intensive Care Unit Cognitive Disorders
- Innovations in Medical Education
- Gastrointestinal motility and disorders
- Hemodynamic Monitoring and Therapy
- Gastroesophageal reflux and treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Airway Management and Intubation Techniques
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Vascular Procedures and Complications
- Pediatric Hepatobiliary Diseases and Treatments
- Pregnancy and preeclampsia studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Pain Management and Opioid Use
- Medical Education and Admissions
- Orthopedic Infections and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Neuropeptides and Animal Physiology
- Diversity and Career in Medicine
University of Vermont Medical Center
2019-2024
University of Vermont
2019-2023
Nationwide Children's Hospital
2015-2019
The Ohio State University
2013-2018
Johns Hopkins University
2010-2014
Johns Hopkins Bayview Medical Center
2010
Johns Hopkins Hospital
2008
University of Rochester
2006
Niagara University
2004
Clinical observations or animal studies implicate enteric glial cells in motility disorders, irritable bowel syndrome, inflammatory disease, gastrointestinal (GI) infections, postoperative ileus, and slow transit constipation. Mechanisms underlying responses to inflammation human GI tract are not understood. Our goal was identify the "reactive cell (rhEGC) phenotype" induced by inflammation, probe its functional relevance.Human culture from 15 GI-surgical specimens were used study gene...
Liu, Chang Amber MD, MSc, FAAP; Lee, Johanna M. MD; Holman, Ashlee Heydinger, Grant Whitaker, Emmett E. Chao, Jerry Y. MSc Author Information
Aims and Method There is a shortage of doctors in the UK, particularly psychiatry pathology. Little known about prospective medical students' career intentions or attitudes. This study aimed to report on attitudes 819 attenders at sixth-form conference for students. Results A much higher proportion students expressed favourable as than might have been expected. The most popular was paediatrics least genitourinary medicine. IMPLICATIONS Medical schools need be proactive providing information,...
We simulated needle paths based on the central landmark used for venous catheterization of internal jugular vein. obtained ultrasound images to quantify landmark's accuracy (precision and bias) in 107 subjects placed Trendelenburg position with their heads turned 30-35 degrees. also determined frequency carotid artery puncture. The path missed middle 80% lumen vein 34% (95% confidence interval [CI], 25% 44%) traversed 26% CI, 18% 35%). Both events occurred 20% 13%-29%). had a medial bias 3.7...
Anesthesia-induced neurotoxicity research in the developing brain must rely upon an unimpeachable animal model and a standardized treatment approach. In this manner, identification of mechanisms action may be undertaken. The goal study was to develop novel, clinically relevant, translational way use piglet investigate anesthesia effects on brain.29 newborn piglets were assigned either: (1) control (no intervention, n = 10); (2) lipopolysaccharide (LPS; positive inflammatory control, 9); or...
Summary Background/Aim Malignant hyperthermia susceptible patients may experience a fatal reaction to volatile anesthetic gases. This study sought determine the washout characteristics of desflurane, sevoflurane, and isoflurane from A isys ® , vance estiva anesthesia machines. ( GE Healthcare, Madison, WI USA ). Methods All machines were inspected by Healthcare engineer prior testing. The primed with desflurane 7 vol%, sevoflurane 2.5 1.2 vol% on three separate occasions for 2 h each gas....
Spinal anesthesia is utilized as an alternative to general in infants for some surgeries. After spinal anesthesia, often become less conscious without administration of sedative medications. The aim this study was assess electroencephalographic (EEG) correlates after a cohort infants.
To perform a single institution review of spinal instead general anesthesia for pediatric patients undergoing surgical procedures. Spinal success rate, intraoperative complications, and postoperative outcomes including unplanned hospital admission emergency department visits within seven days are reported.
There is no conflict of interest. The data that support the findings this study are available from corresponding author upon reasonable request.
Every year, millions of children undergo anesthesia for a multitude procedures. However, studies in both animals and humans have called into question the safety children, implicating anesthetics as potentially toxic to brain development. To date, no successfully elucidated mechanism(s) by which may be neurotoxic. Animal allow investigation such mechanisms, neonatal piglets represent an excellent model study these effects due their striking developmental similarities human brain. This...
Anesthesia cannot be avoided in many cases when surgery is required, particularly children. Recent investigations animals have raised concerns that anesthesia exposure may lead to neuronal apoptosis, known as anesthesia-induced developmental neurotoxicity (AIDN). Furthermore, some clinical studies children suggested neurodevelopmental deficits later life. Nonetheless, an ideal animal model for preclinical study has yet developed. The neonatal piglet represents a valuable study, they share...
Anesthesia cannot be avoided in many cases when surgery is required, particularly children. Recent investigations animals have raised concerns that anesthesia exposure may lead to neuronal apoptosis, known as anesthesia-induced developmental neurotoxicity (AIDN). Furthermore, some clinical studies children suggested neurodevelopmental deficits later life. Nonetheless, an ideal animal model for preclinical study has yet developed. The neonatal piglet represents a valuable study, they share...
Abstract Background As the risks of general anesthesia in infants become clearer, pediatric anesthesiologists are seeking alternatives. Though infant spinal is one such alternative, its use limited by perceived short duration. Prior studies investigating open to interpretation and may not have accurately characterized block onset or density. Surface electromyography a passive, noninvasive modality that can measure effects neural blockade. Aims To quantitatively describe onset, density,...