A5084982602- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- Virology and Viral Diseases
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Toxoplasma gondii Research Studies
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Rabies epidemiology and control
- Mosquito-borne diseases and control
- Infectious Encephalopathies and Encephalitis
- Cannabis and Cannabinoid Research
- Autism Spectrum Disorder Research
- Stress Responses and Cortisol
- Cytomegalovirus and herpesvirus research
- Neurogenesis and neuroplasticity mechanisms
- Renin-Angiotensin System Studies
- Epigenetics and DNA Methylation
- Herpesvirus Infections and Treatments
- Viral Infections and Immunology Research
- Biochemical effects in animals
- Amino Acid Enzymes and Metabolism
Johns Hopkins Medicine
2015-2024
Johns Hopkins University
2015-2024
University at Buffalo, State University of New York
2020-2024
Jacobs (United States)
2021-2023
New York University
2022
H. L. Snyder Medical Foundation
2012-2020
Johns Hopkins Children's Center
2018
Johns Hopkins Hospital
2018
Yale University
2014-2017
VA Connecticut Healthcare System
2014-2017
Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such schizophrenia. DISC1 is promising genetic risk factor illnesses. In this transgenic model, dominant-negative form (DN-DISC1) expressed under the alphaCaMKII promoter. vivo MRI DN-DISC1 detected enlarged lateral ventricles particularly on left side, suggesting link to asymmetrical change in anatomy found brains patients with...
<h3>STUDY OBJECTIVE</h3> To examine the association between exposure to environmental tobacco smoke (ETS) and demographic, lifestyle, occupational characteristics self reported health conditions. <h3>DESIGN</h3> Cross sectional study, using data from multiphasic checkups 1979 1985. <h3>SETTING</h3> Large plan in Northern California, USA. <h3>PARTICIPANTS</h3> 16 524 men aged 15–89 years 26 197 women 15–105 who never smoked. <h3>RESULTS</h3> Sixty eight per cent of 64 any current ETS (at...
Significance [ 11 C]CPPC [5-cyano- N -(4-(4-[ C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide] is a PET radiotracer specific for CSF1R, microglia-specific marker. This compound can be used as noninvasive tool imaging of reactive microglia, disease-associated microglia and their contribution to neuroinflammation in vivo. Neuroinflammation posited an underlying pathogenic feature wide variety neuropsychiatric disorders. may also study specifically the immune environment...
Trisomic Ts65Dn mice show direct parallels with many phenotypes of Down syndrome (DS), including effects on the structure cerebellum and hippocampus. A small segment Hsa21 known as 'DS critical region' (DSCR) has been held to contain a gene or genes sufficient cause impairment in learning memory tasks involving To test this hypothesis, we developed Ts1Rhr Ms1Rhr mouse models that are, respectively, trisomic monosomic for region. Here, trisomy DSCR alone is not produce structural functional...
Previous studies using in vitro cell culture systems have shown the role of dynamin-related GTPase Opa1 apoptosis prevention and mitochondrial DNA (mtDNA) maintenance. However, it remains to be tested whether these functions are physiologically important vivo mammals. Here, Cre-loxP system, we deleted mouse pancreatic beta cells, which glucose-stimulated ATP production mitochondria plays a key insulin secretion. Beta cells lacking maintained normal copy numbers mtDNA; however, amount...
Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 (DISC1) as risk factors for both schizophrenia mood disorders. Recent studies have shown that DISC1 has important functions brain development adult function. We described earlier a transgenic mouse model of inducible expression mutant human (hDISC1) acts dominant-negative manner to induce marked neurobehavioral abnormalities. To gain insight into roles at various stages neurodevelopment,...
Necrotizing enterocolitis–induced brain injury in mice can be prevented with an oral nanotherapeutic that targets microglia.
Significance Human mucosal surfaces contain a wide range of microorganisms. The biological effects these organisms are largely unknown. Large-scale metagenomic sequencing is emerging as method to identify novel microbes. Unexpectedly, we identified DNA sequences homologous virus ATCV-1, an algal not previously known infect humans, in oropharyngeal samples obtained from healthy adults. presence ATCV-1 was associated with modest but measurable decrease cognitive functioning. A relationship...
Oligodendrocytes (OLs) are important for myelination and shuttling energy metabolites lactate pyruvate toward axons through their expression of monocarboxylate transporter 1 (MCT1). Recent studies suggest that loss OL MCT1 causes axonal degeneration. However, it is unknown how widespread chronic in OLs specifically affects neuronal homeostasis with aging. To answer this, conditional null mice were generated allow OL-specific ablation. We observe from lineage cells dispensable normal early...
Toxoplasma gondii reportedly manipulates rodent behaviour to increase transmission its definitive feline host. We compared the effects of mouse infection by two Type II strains T. gondii, Prugniaud (PRU) and ME49, on attraction cat odour, locomotor activity, anxiety, sensorimotor gating, spatial working recognition memory 2 months post-infection (mpi). Attraction odour was reassessed 7 mpi. At mpi, mice infected with either strain exhibited significantly more than uninfected animals did, but...