A5088759125- Herpesvirus Infections and Treatments
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Gut microbiota and health
- Tryptophan and brain disorders
- Diet and metabolism studies
- Vector-Borne Animal Diseases
- Bacteriophages and microbial interactions
- Rabies epidemiology and control
- Pediatric health and respiratory diseases
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- HIV Research and Treatment
- Adenosine and Purinergic Signaling
- Complement system in diseases
- Digestive system and related health
- Cardiac electrophysiology and arrhythmias
- Olfactory and Sensory Function Studies
- Vietnamese History and Culture Studies
- Mental Health Research Topics
- Health, psychology, and well-being
- Helicobacter pylori-related gastroenterology studies
- Psychedelics and Drug Studies
- Trypanosoma species research and implications
- Cannabis and Cannabinoid Research
Johns Hopkins University
2014-2024
Johns Hopkins Medicine
2014-2023
Johns Hopkins Hospital
2017
Stanley Foundation
2014-2015
University of Leeds
2011-2015
University of Illinois Chicago
2006-2009
University of Szeged
2006-2008
The highly prevalent parasite Toxoplasma gondii manipulates its host's behavior. In infected rodents, the behavioral changes increase likelihood that will be transmitted back to definitive cat host, an essential step in completion of parasite's life cycle. mechanism(s) responsible for host is unknown but two lines published evidence suggest alters neurotransmitter signal transduction: disruption parasite-induced with medications used treat psychiatric disease (specifically dopamine...
Significance Human mucosal surfaces contain a wide range of microorganisms. The biological effects these organisms are largely unknown. Large-scale metagenomic sequencing is emerging as method to identify novel microbes. Unexpectedly, we identified DNA sequences homologous virus ATCV-1, an algal not previously known infect humans, in oropharyngeal samples obtained from healthy adults. presence ATCV-1 was associated with modest but measurable decrease cognitive functioning. A relationship...
Infection by the neurotropic agent Toxoplasma gondii alters rodent behavior and can result in neuropsychiatric symptoms humans. Little is understood regarding effects of infection on host neural processes but alterations to dopaminergic neurotransmission are implicated. We have previously reported elevated levels dopamine (DA) infected cells however involvement enzymes fate produced DA were not defined. In order clarify biosynthetic packaging we examined enzyme activity accumulation release...
There is marked variation in the human response to Toxoplasma gondii infection. Epidemiological studies indicate associations between strain virulence and severity of toxoplasmosis. Animal on pathogenic effect chronic infection focused relatively avirulent strains (e.g. type II) because they can easily establish latent infections mice, defined by presence bradyzoite-containing cysts. To provide insight into virulent strain-related toxoplasmosis, we established a model I using outbred mice....
Our knowledge of how genetic risk variants contribute to psychiatric disease is mainly limited neurons. However, the mechanisms whereby same factors could affect physiology glial cells remain poorly understood. We studied role a factor, Disrupted-In-Schizophrenia-1 (DISC1), in metabolic functions astrocytes. evaluated effects knockdown mouse endogenous DISC1 (DISC1-KD) and expression dominant-negative, C-terminus truncated human (DN-DISC1) on markers energy metabolism, including glucose...
Prenatal, perinatal, and postnatal factors have been shown to shape neurobiological functioning alter the risk for mental disorders later in life. The gut microbiome is established early life, interacts with brain via brain-immune-gut axis. However, little known about how relates early-life cognitive children. present study, where fecal of 380 children was characterized using 16S rDNA metagenomic sequencing aimed investigate association between microbiota at age 45 months measured Wechsler...
Small intestinal bacterial overgrowth (SIBO) has been associated with anatomical and motility-related abnormalities. Specifically, obesity postulated to alter small bowel motility, leading SIBO.(i) Assess the prevalence of SIBO in obesity; (ii) determine relationship SIBO, using transit time (SBTT) pH; (iii) profile gut microbiome obese non-obese patients SIBO.Thirty consecutive participants referred for underwent lactulose breath tests (LBTs) wireless motility capsule (WMC) studies....
Purpose: Herpes virus entry mediator (HVEM) plays a critical role in the regulation of inflammation through interaction with its natural ligands LIGHT and lymphotoxin alpha also serves as one receptors herpes simplex (HSV). The purpose this study was to better understand expression HVEM cornea trigeminal ganglia (TG), which are important targets HSV infection.Materials Methods: Immunohistochemistry used define TG normal HSV-1 infected mice euthanized 2 5 days or 7 months following corneal...
Complex brain disorders like schizophrenia may have multifactorial origins related to mis-timed heritable and environmental factors interacting during neurodevelopment. Infections, inflammation, autoimmune diseases are over-represented in leading immune system-centered hypotheses. Complement component C4 is genetically neurobiologically associated with schizophrenia, its dual activity peripherally the makes it an exceptional target for biomarker development. Studies evaluate potential of...
Toxoplasma gondii is an obligate intracellular parasite with worldwide distribution. Felines are the definitive hosts supporting complete life cycle of T. gondii. However, other warm-blooded animals such as rodents and humans can also be infected. Infection secondary results in long-term infection characterized by presence tissue cysts brain organs. While it known that associated behavioral changes, mechanisms behind these changes remain unclear. Alterations host intestinal microflora...
Infection with the protozoan parasite, Toxoplasma gondii ( T. ), was linked to several psychiatric disorders. The exact mechanisms of a hypothesized contribution infection are poorly understood, and it appears that only subset seropositive individuals go on develop mental illness, suggesting genetic vulnerability. In order stimulate mechanistic studies how exposure could interact predisposition disorders, we have generated characterized mouse model chronic in BALB/c mice inducible forebrain...