A5084933705- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Pregnancy-related medical research
- Genetic Syndromes and Imprinting
- Reproductive tract infections research
- Oral microbiology and periodontitis research
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Infant Nutrition and Health
- Maternal and Perinatal Health Interventions
- COVID-19 Impact on Reproduction
- Prenatal Screening and Diagnostics
- Neuroendocrine regulation and behavior
- Pregnancy and Medication Impact
- Infant Development and Preterm Care
- Cervical Cancer and HPV Research
- Neonatal and Maternal Infections
- Dental Health and Care Utilization
- Blood Coagulation and Thrombosis Mechanisms
- Reproductive Physiology in Livestock
- Urological Disorders and Treatments
University of California, San Francisco
2019-2024
Duke University Health System
2016-2023
Johnson University
2023
Rutgers, The State University of New Jersey
2023
Duke University
2012-2022
Society for Maternal-Fetal Medicine
2006-2022
Reproductive Science Center
2019-2022
Duke University Hospital
2004-2018
Duke Medical Center
2007-2018
University of Alabama at Birmingham
2017
Oral Conditions and Pregnancy (OCAP) is a 5‐year prospective study of pregnant women designed to determine whether maternal periodontal disease contributes the risk for prematurity growth restriction in presence traditional obstetric factors. Full‐mouth examinations were conducted at enrollment (prior 26 weeks gestational age) again within 48 hours postpartum assess changes status during pregnancy. Maternal antepartum, using 3‐level classification (health, mild, moderate‐severe) as well...
In Brief OBJECTIVE: The goal was to estimate whether maternal periodontal disease predictive of preterm (less than 37 weeks) or very 32 births. METHODS: A prospective study obstetric outcomes, entitled Oral Conditions and Pregnancy (OCAP), conducted with 1,020 pregnant women who received both an antepartum postpartum examination. Predictive models were developed exposure either at enrollment 26 and/or progression during pregnancy, as determined by comparing status, births, adjusting for risk...
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at level epigenetic machinery. Besides in vitro environmental exposures, possible impact on reprogramming methylation profiles imprinted genes a much earlier time point, such as spermatogenesis or oogenesis, has not previously been considered. In this study, our aim was to...
Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects been attributed to epigenetic changes, such as DNA methylation shifts at imprinted genes, little is known about potential maternal paternal preconceptional overnutrition or obesity.We examined parental obesity relation profiles multiple human genes important normal growth development, as:...
Folic acid (FA) supplementation before and during pregnancy has been associated with decreased risk of neural tube defects although recent reports suggest it may also increase the other chronic diseases. We evaluated exposure to maternal FA in relation aberrant DNA methylation at two differentially methylated regions (DMRs) regulating Insulin-like Growth Factor 2 (IGF2) expression infants. Aberrant these IGF2 deregulation increased susceptibility several Using a self-administered...
Previous studies have demonstrated the presence of microbial DNA in fetal environment. However, it remains unclear whether this represents viable bacteria and how relates to maternal microbiota across body sites. We studied human mouse dyads understand these relationships, localize fetus, demonstrate bacterial viability. In preterm full-term mother-infant at time cesarean delivery, oral cavity meconium newborn infants born as early 24 weeks gestation contained a that was predicted originate...
BACKGROUND: Among women with hypertensive disorders of pregnancy, biomarkers may stratify risk for developing preeclampsia severe features (sPE). METHODS: Across 18 U.S. centers, we prospectively measured the ratio serum soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) in pregnant hospitalized between 23 and 35 weeks gestation. The primary outcome was predicting sPE, secondary outcomes included adverse within 2 weeks. prognostic performance sFlt-1:PlGF assessed...
OBJECTIVE: To determine if maternal periodontal disease is associated with the development of preeclampsia. METHODS: A cohort 1115 healthy pregnant women were enrolled at less than 26 weeks' gestation and followed until delivery. Maternal demographic medical data collected. Periodontal examinations performed enrollment within 48 hours delivery to presence severe or progression. Preeclampsia was defined as blood pressure greater 140/90 on two separate occasions, least 1+ proteinuria...
Clinical data from the first 812 deliveries a cohort study of pregnant mothers entitled Oral Conditions and Pregnancy (OCAP) demonstrate that both antepartum maternal periodontal disease incidence/progression are associated with preterm birth growth restriction after adjusting for traditional obstetric risk factors. In current we present measures infection using whole chromosomal DNA probes to identify 15 organisms within plaque sampled at delivery. addition, postpartum IgG antibody fetal...
In Brief OBJECTIVE: To test the effects of maternal periodontal disease treatment on incidence preterm birth (delivery before 37 weeks gestation). METHODS: The Maternal Oral Therapy to Reduce Obstetric Risk Study was a randomized, treatment-masked, controlled clinical trial pregnant women with who were receiving standard obstetric care. Participants assigned either arm, consisting scaling and root planing early in second trimester, or delayed arm that provided care after delivery. Pregnancy...
Background: Our objective was to describe the oral health of pregnant women, determine changes during pregnancy, and factors associated with maternal periodontal or disease. Materials Methods: Between December 1997 July 2001, 1,224 women at <26 weeks’ gestation were enrolled in study examinations performed enrollment within 48 hours delivery. Demographic, medical, behavior data determined by chart abstraction questionnaire. Comparisons between delivery made student t test Fisher's exact...
Depressed mood in pregnancy has been linked to low birth weight (LBW, < 2,500 g), a risk factor for adult-onset chronic diseases offspring. We examined maternal depressed relation and evaluated the role of DNA methylation at regulatory sequences imprinted genes this association. measured among 922 pregnant women using CES-D scale obtained data from hospital records. Using bisulfite pyrosequencing cord blood 508 infants, we differentially methylated regions (DMRs) regulating IGF2/H19,...
Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposure to antibiotics may also increase the risk LBW. mechanisms underlying this association are unknown, although epigenetic hypothesized. In study, we evaluated between maternal antibiotic use examined potential role altered DNA methylation that controls...
Folic acid (FA) added to foods during fortification is 70-85% bioavailable compared 50% of folate occurring naturally in foods. Thus, if FA supplements also are taken pregnancy, both mother and fetus can be exposed exceeding the Institute Medicine's recommended tolerable upper limit (TUL) 1,000 micrograms per day (μg/d) for adult pregnant women. The primary objective estimate proportion women taking folic doses TUL before identify correlates high use.During 2005-2008, pre-pregnancy...
In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers for neurodevelopmental disorders, cardiovascular disease, and cancers adulthood. We examined associations between prenatal PTB, evaluating the role DNA methylation at imprint regulatory regions. enrolled women from clinics Durham, NC. Stress was measured 537 12 weeks gestation using Perceived Scale. differentially...
Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis obesity essential metals including zinc (Zn) iron (Fe) may alter these outcomes. However mechanisms underlying relationships remain limited. We examined whether maternal Cd levels during early pregnancy were associated with offspring DNA methylation at regulatory sequences of genomically imprinted genes weight birth, Fe Zn altered associations. Cd, measured blood...
Background Data regarding symptoms in the lactating mother-infant dyad and their immune response to COVID-19 mRNA vaccination during lactation are needed inform guidelines. Methods From a prospective cohort of 50 individuals who received mRNA-based vaccines for (mRNA-1273 BNT162b2), blood milk samples were collected prior first dose, immediately 2nd 4-10 weeks after dose. Symptoms mother infant assessed by detailed questionnaires. Anti-SARS-CoV-2 antibody levels measured Pylon 3D automated...
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, levels protection provided their newborns through placental transfer antibodies. Here, we transplacental vaccine products functional anti-SARS-CoV-2 antibodies pregnancy early infancy in a cohort 20 individuals vaccinated late pregnancy. We find no evidence maternal blood, placenta tissue, or cord blood at delivery. However, time-dependent efficient IgG neutralizing neonate that...
Altered methylation at Insulin-like Growth Factor 2 (IGF2) regulatory regions has previously been associated with obesity, and several malignancies including colon, esophageal, prostate adenocarcinomas, presumably via changes in expression and/or loss of imprinting, but the functional significance these DNA marks have not demonstrated humans. We examined associations among IGF2 differentially methylated (DMRs), circulating protein concentrations umbilical cord blood (UCB) birth weight...